Sirolimus

TSC complex subunit 1 ; Homo sapiens







123 Article(s)
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Pub. Year
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1 35246210 Perfect match: mTOR inhibitors and tuberous sclerosis complex. 2022 Mar 4 1
2 35359647 Abnormal White Matter Microstructure in the Limbic System Is Associated With Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders. 2022 1
3 35483522 Blocking ribosomal protein S6 phosphorylation inhibits podocyte hypertrophy and focal segmental glomerulosclerosis. 2022 Apr 25 1
4 35596872 Genetic analysis of 18 families with tuberous sclerosis complex. 2022 May 21 1
5 33307091 Architecture of the Tuberous Sclerosis Protein Complex. 2021 Jan 22 1
6 33398801 Revisiting Brain Tuberous Sclerosis Complex in Rat and Human: Shared Molecular and Cellular Pathology Leads to Distinct Neurophysiological and Behavioral Phenotypes. 2021 Apr 2
7 33431351 Genetic pathogenesis of the epileptogenic lesions in Tuberous Sclerosis Complex: Therapeutic targeting of the mTOR pathway. 2021 Jan 8 1
8 33658088 Everolimus treatment in a 3-month-old infant with tuberous sclerosis complex cardiac rhabdomyoma, severe left ventricular outflow tract obstruction, and hearing loss. 2021 Aug 2
9 33773987 Long-Term Effects of Sirolimus on Human Skin TSC2-Null Fibroblast‒Like Cells. 2021 Sep 3
10 33860865 Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited. 2021 Jun 1
11 33891611 Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer. 2021 1
12 33902956 Sirolimus-based immunosuppression improves the prognosis of liver Transplantation Recipients with low TSC1/2 expression in hepatocellular carcinoma beyond the Milan Criteria. 2021 Oct 8
13 33910008 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. 2021 Apr 27 1
14 33923449 The Characterization of a Subependymal Giant Astrocytoma-Like Cell Line from Murine Astrocyte with mTORC1 Hyperactivation. 2021 Apr 16 5
15 34079249 Mesenchymal Stem Cells Attenuate Renal Fibrosis via Exosomes-Mediated Delivery of microRNA Let-7i-5p Antagomir. 2021 1
16 34178631 Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations. 2021 3
17 34295558 TSC1/2 mutations-a unique type of mutation suitable for liver transplantation of Hepatocellular carcinoma. 2021 Jun 2
18 34301883 Tsc1 regulates tight junction independent of mTORC1. 2021 Jul 27 2
19 34349839 Review of the treatment options for epilepsy in tuberous sclerosis complex: towards precision medicine. 2021 2
20 34544857 Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells. 2021 Sep 28 1
21 34778262 The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back. 2021 1
22 34806651 Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice. 2021 Nov 22 1
23 34853810 RUNX1/EGFR pathway contributes to STAT3 activation and tumor growth caused by hyperactivated mTORC1. 2021 Dec 17 1
24 31834371 The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas. 2020 Jan 1 2
25 31869431 Chronic activation of anti-oxidant pathways and iron accumulation in epileptogenic malformations. 2020 Oct 1
26 31921404 TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling. 2020 5
27 31958214 Upregulation of 6-phosphofructo-2-kinase (PFKFB3) by hyperactivated mammalian target of rapamycin complex 1 is critical for tumor growth in tuberous sclerosis complex. 2020 May 5
28 32469097 miR-196b-5p controls adipocyte differentiation and lipogenesis through regulating mTORC1 and TGF-β signaling. 2020 Jul 1
29 32502382 Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations. 2020 Aug 4 1
30 32541317 Medical treatment of advanced malignant perivascular epithelioid cell tumors. 2020 Jul 1
31 32579942 Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia. 2020 Jun 23 1
32 32739207 Tuberous sclerosis 1 (Tsc1) mediated mTORC1 activation promotes glycolysis in tubular epithelial cells in kidney fibrosis. 2020 Sep 2
33 32761379 Genetics of tuberous sclerosis complex: an update. 2020 Oct 1
34 32765227 The Neurodevelopmental Pathogenesis of Tuberous Sclerosis Complex (TSC). 2020 2
35 32927859 Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells. 2020 Sep 10 1
36 33193709 Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning. 2020 1
37 30728291 Abnormal glycogen storage in tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways. 2019 Feb 19 2
38 30904097 Finding a cure for tuberous sclerosis complex: From genetics through to targeted drug therapies. 2019 3
39 30988224 [Tuberous Sclerosis Complex]. 2019 Apr 2
40 31665839 [Rapamycin in the treatment of renal diseases associated with tuberous sclerosis complex]. 2019 Nov 2 2
41 29339522 Effect of beta-agonists on LAM progression and treatment. 2018 Jan 30 2
42 29340326 mTORC1 Inhibition Is an Effective Treatment for Sporadic Renal Angiomyolipoma. 2018 Jan 2
43 29478616 Tuberous sclerosis complex. 2018 2
44 29559472 Plk1-Mediated Phosphorylation of TSC1 Enhances the Efficacy of Rapamycin. 2018 Jun 1 3
45 29929111 Calcification in cerebral parenchyma affects pharmacoresistant epilepsy in tuberous sclerosis. 2018 Aug 1
46 30087333 TSC1 and DEPDC5 regulate HIV-1 latency through the mTOR signaling pathway. 2018 Aug 8 1
47 30127391 Genetically engineered human cortical spheroid models of tuberous sclerosis. 2018 Oct 2
48 30144504 Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation. 2018 Oct 2
49 27225870 Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer. 2017 Feb 1
50 27862655 Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex. 2017 Jan 5