Terfenadine

cytochrome P450 family 2 subfamily J member 2 ; Homo sapiens







20 Article(s)
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1 32249832 Generation of intestinal organoids derived from human pluripotent stem cells for drug testing. 2020 Apr 6 1
2 33335233 Molecular determinant of substrate binding and specificity of cytochrome P450 2J2. 2020 Dec 17 2
3 29223463 Terfenadine metabolism of human cytochrome P450 2J2 containing genetic variations (G312R, P351L and P115L). 2018 Feb 1
4 29759885 Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes. 2018 Jun 4
5 28237650 Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy. 2017 Jul 1 1
6 29911373 [Research progress of human cytochrome P450 2J2 and its ligands]. 2017 Jan 1
7 26899760 Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine. 2016 Nov 1
8 25857771 Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies. 2015 Jul 1
9 26048912 Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner. 2015 Aug 4
10 24788058 Potential of decursin to inhibit the human cytochrome P450 2J2 isoform. 2014 Aug 1
11 24997310 A note on CYP2J2-mediated terfenadine hydroxylation in human liver microsomes. 2014 Sep 1
12 24998194 Response to comment: "A note on CYP2J2-mediated terfenadine hydroxylation in human liver microsomes". 2014 Sep 1
13 23688135 CYP epoxygenase derived EETs: from cardiovascular protection to human cancer therapy. 2013 1
14 24021950 Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes. 2013 Dec 1
15 22328583 Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. 2012 May 1
16 21477627 The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases. 2011 Jul 18 1
17 19923256 Identification of novel substrates for human cytochrome P450 2J2. 2010 Feb 1
18 19289568 Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo. 2009 Jun 2
19 17470359 Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2. 2007 Aug 15 1
20 16495056 Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2. 2006 May 15 2