lorlatinib

anaplastic lymphoma kinase ; Mus musculus







10 Article(s)
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1 34819663 The CLIP1-LTK fusion is an oncogenic driverĀ in non-small-cell lung cancer. 2021 Dec 1
2 31943796 Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non-small cell lung cancer. 2020 Mar 1
3 30660696 Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib. 2019 Mar 4
4 30662002 Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance. 2019 Mar 1
5 29550682 Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry. 2018 Apr 15 2
6 29650534 Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer. 2018 Jun 1
7 29744867 P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib. 2018 Oct 15 7
8 30149189 Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates. 2018 Nov 30 1
9 30322862 Lorlatinib Treatment Elicits Multiple On- and Off-Target Mechanisms of Resistance in ALK-Driven Cancer. 2018 Dec 15 5
10 29048652 Activation of Src signaling mediates acquired resistance to ALK inhibition in lung cancer. 2017 Nov 2