| 1 |
28126652 | A de novo mutation in the X-linked PAK3 gene is the underlying cause of intellectual disability and macrocephaly in monozygotic twins. | 2017 Apr |
1 |
| 2 |
26828437 | Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor. | 2016 |
1 |
| 3 |
25567764 | Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells. | 2015 Feb 11 |
1 |
| 4 |
26375402 | Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. | 2015 Dec |
1 |
| 5 |
24309939 | Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. | 2013 Dec 5 |
1 |
| 6 |
22385209 | Electrostatic effects of mutations of Ras glutamine 61 measured using vibrational spectroscopy of a thiocyanate probe. | 2012 Apr 3 |
2 |
| 7 |
22404134 | p21-Activated kinase inhibitors: a patent review. | 2012 Mar |
2 |
| 8 |
21396949 | Intracellular GTP level determines cell's fate toward differentiation and apoptosis. | 2011 Jun 15 |
1 |
| 9 |
17094109 | Mechanisms of guanosine triphosphate hydrolysis by Ras and Ras-GAP proteins as rationalized by ab initio QM/MM simulations. | 2007 Feb 1 |
11 |
| 10 |
17632540 | alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression. | 2007 Sep |
1 |
| 11 |
16298082 | Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene. | 2006 |
1 |
| 12 |
16698776 | A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction. | 2006 Aug 1 |
1 |
| 13 |
15906320 | QM/MM modeling the Ras-GAP catalyzed hydrolysis of guanosine triphosphate. | 2005 Aug 15 |
3 |
| 14 |
16049137 | Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling. | 2005 Oct |
1 |
| 15 |
16054119 | T-type calcium channel trigger p21ras signaling pathway to ERK in Cav3.1-expressed HEK293 cells. | 2005 Aug 23 |
1 |
| 16 |
16323045 | Comparison of the predicted structures of loops in the ras-SOS protein bound to a single ras-p21 protein with the crystallographically determined structures in SOS bound to two ras-p21 proteins. | 2005 Aug |
1 |
| 17 |
15059972 | Cyclic AMP promotes a peripheral distribution of melanosomes and stimulates melanophilin/Slac2-a and actin association. | 2004 Jun |
1 |
| 18 |
15200053 | Comparison of molecular dynamics averaged structures for complexes of normal and oncogenic ras-p21 with SOS nucleotide exchange protein, containing computed conformations for three crystallographically undefined domains, suggests a potential role of these domains in ras signaling. | 2004 Apr |
3 |
| 19 |
12799645 | Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. | 2003 Jun 16 |
1 |
| 20 |
12206509 | Comparison of the average structures, from molecular dynamics, of complexes of GTPase activating protein (GAP) with oncogenic and wild-type ras-p21: identification of potential effector domains. | 2002 Jul |
1 |
| 21 |
12354753 | Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence. | 2002 Sep |
2 |
| 22 |
11593437 | Activation of the RacGTPase inhibits apoptosis in human tumor cells. | 2001 Sep 27 |
1 |
| 23 |
11694593 | Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase. | 2001 Nov |
1 |
| 24 |
11721009 | Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism. | 2001 Dec |
2 |
| 25 |
11746677 | Revisiting the structural flexibility of the complex p21(ras)-GTP: the catalytic conformation of the molecular switch II. | 2001 Dec 1 |
2 |
| 26 |
11111922 | The p21 GTP-binding proteins and bacterial toxins. | 2000 Oct |
1 |
| 27 |
11188692 | Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation. | 2000 Dec 15 |
3 |
| 28 |
10198354 | Gialpha but not gqalpha is linked to activation of p21(ras) in human airway smooth muscle cells. | 1999 Apr |
3 |
| 29 |
10469432 | Hyperactive Ras as a therapeutic target in neurofibromatosis type 1. | 1999 Mar 26 |
1 |
| 30 |
10494844 | Molecular reaction mechanisms of proteins monitored by time-resolved FTIR-spectroscopy. | 1999 Jul-Aug |
1 |
| 31 |
10551809 | Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. | 1999 Nov 12 |
1 |
| 32 |
10574788 | The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. | 1999 Nov 15 |
5 |
| 33 |
10585950 | Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21. | 1999 Dec |
1 |
| 34 |
9624180 | Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes. | 1998 Jun 19 |
1 |
| 35 |
9661152 | Fourier transform infrared photolysis studies of caged compounds. | 1998 |
1 |
| 36 |
9693007 | Raman difference studies of GDP and GTP binding to c-Harvey ras. | 1998 Aug 4 |
1 |
| 37 |
9774361 | Role of calcium-sensitive tyrosine kinase Pyk2/CAKbeta/RAFTK in angiotensin II induced Ras/ERK signaling. | 1998 Oct |
1 |
| 38 |
9778365 | The role of ligand binding in the kinetic folding mechanism of human p21(H-ras) protein. | 1998 Oct 20 |
1 |
| 39 |
9871712 | Prediction of the GTPase activities by using the semiempirical molecular orbital theory. | 1998 May 5 |
3 |
| 40 |
9038193 | Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. | 1997 Feb 28 |
1 |
| 41 |
9067995 | [Analysis of the cellular functions of the small GTP-binding protein rho p21 with Clostridium botulinum C3 exoenzyme]. | 1997 Jan |
1 |
| 42 |
9112760 | Inhibition of the GDP/GTP exchange reaction of ras p21 by aluminum ion. | 1997 May 1 |
2 |
| 43 |
9188453 | Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells. | 1997 Jun 20 |
1 |
| 44 |
9194162 | Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics. | 1997 Apr |
3 |
| 45 |
9223188 | Calculation of pathways for the conformational transition between the GTP- and GDP-bound states of the Ha-ras-p21 protein: calculations with explicit solvent simulations and comparison with calculations in vacuum. | 1997 Jul |
2 |
| 46 |
9309221 | The frozen solution structure of p21 ras determined by ESEEM spectroscopy reveals weak coordination of Thr35 to the active site metal ion. | 1997 Aug 15 |
5 |
| 47 |
9342335 | Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21. | 1997 Oct 28 |
1 |
| 48 |
9374488 | Nucleotide hydrolysis-dependent conformational changes in p21(ras) as studied using ESR spectroscopy. | 1997 Nov 28 |
2 |
| 49 |
9398520 | Ligand-induced conformational changes in ras p21: a normal mode and energy minimization analysis. | 1997 Nov 21 |
1 |
| 50 |
8608802 | The involvement of the rho gene product, a small molecular weight GTP-binding protein, in polyploidization of a human megakaryocytic cell line, CMK. | 1996 Mar |
1 |