| 1 |
35568200 | Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery. | 2022 May 11 |
1 |
| 2 |
33824328 | Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer. | 2021 Apr 6 |
3 |
| 3 |
31748385 | Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family. | 2020 Jan 31 |
2 |
| 4 |
31910901 | Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus. | 2020 Jan 7 |
1 |
| 5 |
30902068 | Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis. | 2019 Mar 22 |
1 |
| 6 |
30987342 | CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. | 2019 Apr 4 |
3 |
| 7 |
31077566 | Evaluation of critical design parameters for RT-qPCR-based analysis of multiple dUTPase isoform genes in mice. | 2019 Jun |
1 |
| 8 |
31391279 | Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme. | 2019 Aug 7 |
3 |
| 9 |
31662460 | Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target. | 2019 Oct 29 |
1 |
| 10 |
31796083 | Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity. | 2019 Dec 3 |
2 |
| 11 |
28729658 | Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes. | 2017 Jul 20 |
3 |
| 12 |
27498408 | Characterization and functional studies of fowl adenovirus 9 dUTPase. | 2016 Oct |
1 |
| 13 |
26208523 | The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. | 2015 Oct |
1 |
| 14 |
26666293 | Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. | 2015 Dec 15 |
1 |
| 15 |
22655049 | The dUTPase enzyme is essential in Mycobacterium smegmatis. | 2012 |
1 |
| 16 |
21454646 | The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine. | 2011 May 6 |
1 |
| 17 |
19879316 | Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases. | 2010 Feb |
1 |
| 18 |
18608754 | Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. | 2009 Feb |
1 |
| 19 |
18619713 | Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. | 2009 Feb |
1 |
| 20 |
19015155 | Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. | 2009 Jan |
1 |
| 21 |
19342774 | Crystallization and preliminary X-ray analysis of three dUTPases from Gram-positive bacteria. | 2009 Apr 1 |
1 |
| 22 |
18321387 | Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine. | 2008 Mar 5 |
2 |
| 23 |
18586121 | Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase. | 2008 Sep |
1 |
| 24 |
18646465 | Identification and characterization of duck enteritis virus dUTPase gene. | 2008 Jun |
1 |
| 25 |
18790783 | Novel opportunities for thymidylate metabolism as a therapeutic target. | 2008 Sep |
1 |
| 26 |
19055736 | Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice. | 2008 Dec 2 |
1 |
| 27 |
17452782 | Structures of vaccinia virus dUTPase and its nucleotide complexes. | 2007 May |
2 |
| 28 |
17459559 | Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase. | 2007 Aug |
3 |
| 29 |
17544982 | Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives. | 2007 Jul |
1 |
| 30 |
15939294 | Cloning, expression, purification, and characterisation of the dUTPase encoded by the integrated Bacillus subtilis temperate bacteriophage SPbeta. | 2005 Jul |
1 |
| 31 |
16154087 | The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases. | 2005 Sep |
1 |
| 32 |
14724274 | Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme. | 2004 Apr 23 |
1 |
| 33 |
15450848 | Calorimetric determination of thermodynamic parameters of 2'-dUMP binding to Leishmania major dUTPase. | 2004 Oct 1 |
4 |
| 34 |
12670946 | A bifunctional dCTP deaminase-dUTP nucleotidohydrolase from the hyperthermophilic archaeon Methanocaldococcus jannaschii. | 2003 Jun 6 |
1 |
| 35 |
12756253 | Structure of the bifunctional dCTP deaminase-dUTPase from Methanocaldococcus jannaschii and its relation to other homotrimeric dUTPases. | 2003 Jul 25 |
1 |
| 36 |
12799180 | Identification of sequence determinants of human nuclear dUTPase isoform localization. | 2003 Jul 1 |
1 |
| 37 |
12376965 | Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. | 2002 Dec |
1 |
| 38 |
12369927 | Glycine rich P-loop motif in deoxyuridine pyrophosphatase. | 2001 Dec |
1 |
| 39 |
12374095 | The role of dUTPase and uracil-DNA repair in cancer chemotherapy. | 2001 Dec |
1 |
| 40 |
10952785 | Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. | 2000 Sep |
1 |
| 41 |
10957629 | Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms. | 2000 Sep |
2 |
| 42 |
10355777 | Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) ORF54 encodes a functional dUTPase expressed in the lytic replication cycle. | 1999 May |
1 |
| 43 |
10698291 | An isotopic assay of dUTPase activity based on coupling with thymidylate synthase. | 1999 |
1 |
| 44 |
10794525 | Cloning and expression of the mouse deoxyuridine triphosphate nucleotidohydrolase gene: differs from the rat enzyme in that it lacks nuclear receptor interacting LXXLL motif. | 1999 |
1 |
| 45 |
9497317 | Biochemical and phylogenetic characterization of the dUTPase from the archaeal virus SIRV. | 1998 Mar 13 |
1 |
| 46 |
8604980 | Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site. | 1996 Feb 15 |
1 |
| 47 |
8798636 | Kinetic characterization of dUTPase from Escherichia coli. | 1996 Sep 27 |
1 |
| 48 |
8805593 | Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. | 1996 Sep 15 |
4 |
| 49 |
9000104 | The dUTPases from herpes simplex virus type 1 and mouse mammary tumour virus are less specific than the Escherichia coli enzyme. | 1996 Dec |
2 |
| 50 |
7663176 | dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification. | 1995 Jun |
1 |