2'-deoxyuridylic acid

Deoxyuridine triphosphatase ; Drosophila melanogaster







58 Article(s)
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1 35568200 Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery. 2022 May 11 1
2 33824328 Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer. 2021 Apr 6 3
3 31748385 Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family. 2020 Jan 31 2
4 31910901 Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus. 2020 Jan 7 1
5 30902068 Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis. 2019 Mar 22 1
6 30987342 CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. 2019 Apr 4 3
7 31077566 Evaluation of critical design parameters for RT-qPCR-based analysis of multiple dUTPase isoform genes in mice. 2019 Jun 1
8 31391279 Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme. 2019 Aug 7 3
9 31662460 Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target. 2019 Oct 29 1
10 31796083 Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity. 2019 Dec 3 2
11 28729658 Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes. 2017 Jul 20 3
12 27498408 Characterization and functional studies of fowl adenovirus 9 dUTPase. 2016 Oct 1
13 26208523 The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. 2015 Oct 1
14 26666293 Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. 2015 Dec 15 1
15 22655049 The dUTPase enzyme is essential in Mycobacterium smegmatis. 2012 1
16 21454646 The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine. 2011 May 6 1
17 19879316 Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases. 2010 Feb 1
18 18608754 Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. 2009 Feb 1
19 18619713 Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. 2009 Feb 1
20 19015155 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. 2009 Jan 1
21 19342774 Crystallization and preliminary X-ray analysis of three dUTPases from Gram-positive bacteria. 2009 Apr 1 1
22 18321387 Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine. 2008 Mar 5 2
23 18586121 Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase. 2008 Sep 1
24 18646465 Identification and characterization of duck enteritis virus dUTPase gene. 2008 Jun 1
25 18790783 Novel opportunities for thymidylate metabolism as a therapeutic target. 2008 Sep 1
26 19055736 Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice. 2008 Dec 2 1
27 17452782 Structures of vaccinia virus dUTPase and its nucleotide complexes. 2007 May 2
28 17459559 Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase. 2007 Aug 3
29 17544982 Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives. 2007 Jul 1
30 15939294 Cloning, expression, purification, and characterisation of the dUTPase encoded by the integrated Bacillus subtilis temperate bacteriophage SPbeta. 2005 Jul 1
31 16154087 The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases. 2005 Sep 1
32 14724274 Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme. 2004 Apr 23 1
33 15450848 Calorimetric determination of thermodynamic parameters of 2'-dUMP binding to Leishmania major dUTPase. 2004 Oct 1 4
34 12670946 A bifunctional dCTP deaminase-dUTP nucleotidohydrolase from the hyperthermophilic archaeon Methanocaldococcus jannaschii. 2003 Jun 6 1
35 12756253 Structure of the bifunctional dCTP deaminase-dUTPase from Methanocaldococcus jannaschii and its relation to other homotrimeric dUTPases. 2003 Jul 25 1
36 12799180 Identification of sequence determinants of human nuclear dUTPase isoform localization. 2003 Jul 1 1
37 12376965 Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases. 2002 Dec 1
38 12369927 Glycine rich P-loop motif in deoxyuridine pyrophosphatase. 2001 Dec 1
39 12374095 The role of dUTPase and uracil-DNA repair in cancer chemotherapy. 2001 Dec 1
40 10952785 Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. 2000 Sep 1
41 10957629 Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms. 2000 Sep 2
42 10355777 Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) ORF54 encodes a functional dUTPase expressed in the lytic replication cycle. 1999 May 1
43 10698291 An isotopic assay of dUTPase activity based on coupling with thymidylate synthase. 1999 1
44 10794525 Cloning and expression of the mouse deoxyuridine triphosphate nucleotidohydrolase gene: differs from the rat enzyme in that it lacks nuclear receptor interacting LXXLL motif. 1999 1
45 9497317 Biochemical and phylogenetic characterization of the dUTPase from the archaeal virus SIRV. 1998 Mar 13 1
46 8604980 Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site. 1996 Feb 15 1
47 8798636 Kinetic characterization of dUTPase from Escherichia coli. 1996 Sep 27 1
48 8805593 Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. 1996 Sep 15 4
49 9000104 The dUTPases from herpes simplex virus type 1 and mouse mammary tumour virus are less specific than the Escherichia coli enzyme. 1996 Dec 2
50 7663176 dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification. 1995 Jun 1