| 1 |
35568200 | Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery. | 2022 May 11 |
1 |
| 2 |
33824328 | Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer. | 2021 Apr 6 |
2 |
| 3 |
34777521 | The dUTPase of caprine arthritis-encephalitis virus negatively regulates interferon signaling pathway. | 2021 Summer |
2 |
| 4 |
30902068 | Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis. | 2019 Mar 22 |
3 |
| 5 |
30987342 | CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. | 2019 Apr 4 |
3 |
| 6 |
31662460 | Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target. | 2019 Oct 29 |
1 |
| 7 |
28423595 | dUTPase inhibition augments replication defects of 5-Fluorouracil. | 2017 Apr 4 |
1 |
| 8 |
27933035 | Life without dUTPase. | 2016 |
1 |
| 9 |
25735890 | dUTPase expression correlates with cell division potential in Drosophila melanogaster. | 2015 May |
1 |
| 10 |
25841100 | Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium. | 2015 Jun |
1 |
| 11 |
26208523 | The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. | 2015 Oct |
1 |
| 12 |
23307478 | Backbone nuclear magnetic resonance assignment of human deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase). | 2014 Apr |
2 |
| 13 |
25274731 | Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control. | 2014 Oct 29 |
2 |
| 14 |
23201394 | Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants. | 2013 Jan |
1 |
| 15 |
23982515 | Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling. | 2013 Dec |
1 |
| 16 |
23040389 | Characterization and PCR applications of dUTPase from the hyperthermophilic euryarchaeon Thermococcus pacificus. | 2012 Dec 10 |
1 |
| 17 |
21145358 | Evidence for a second messenger function of dUTP during Bax mediated apoptosis of yeast and mammalian cells. | 2011 Feb |
1 |
| 18 |
18619713 | Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. | 2009 Feb |
1 |
| 19 |
18837522 | Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. | 2009 Jan 20 |
1 |
| 20 |
19342774 | Crystallization and preliminary X-ray analysis of three dUTPases from Gram-positive bacteria. | 2009 Apr 1 |
1 |
| 21 |
18586121 | Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase. | 2008 Sep |
2 |
| 22 |
18790783 | Novel opportunities for thymidylate metabolism as a therapeutic target. | 2008 Sep |
1 |
| 23 |
19055736 | Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice. | 2008 Dec 2 |
1 |
| 24 |
17459559 | Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase. | 2007 Aug |
2 |
| 25 |
15629463 | Modulation of human dUTPase using small interfering RNA. | 2005 Feb 4 |
2 |
| 26 |
15276840 | Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. | 2004 Aug 6 |
1 |
| 27 |
15971611 | [Affection of metallothionein-3 to dUTPase's accommodating cellular toxicity of dUTP]. | 2004 May |
2 |
| 28 |
12799180 | Identification of sequence determinants of human nuclear dUTPase isoform localization. | 2003 Jul 1 |
1 |
| 29 |
11487279 | The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition. | 2001 Aug 3 |
1 |
| 30 |
12369926 | Homotrimeric dUTPases; structural solutions for specific recognition and hydrolysis of dUTP. | 2001 Dec |
1 |
| 31 |
12374095 | The role of dUTPase and uracil-DNA repair in cancer chemotherapy. | 2001 Dec |
2 |
| 32 |
12374098 | Trypanosomal dUTPases as potential targets for drug design. | 2001 Dec |
1 |
| 33 |
10657253 | Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids. | 2000 Feb 15 |
1 |
| 34 |
10910061 | dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer. | 2000 Jul 1 |
1 |
| 35 |
10952785 | Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. | 2000 Sep |
3 |
| 36 |
10957629 | Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms. | 2000 Sep |
1 |
| 37 |
10329142 | Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target. | 1999 Apr 30 |
1 |
| 38 |
9360704 | dUTP pyrophosphatase as a potential target for chemotherapeutic drug development. | 1997 |
1 |
| 39 |
8551582 | Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses. | 1996 Feb |
1 |
| 40 |
8735843 | Synthesis of 2'-deoxyuridine 5'-(alpha,beta-imido) triphosphate: a substrate analogue and potent inhibitor of dUTPase. | 1996 Apr |
1 |
| 41 |
8805593 | Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. | 1996 Sep 15 |
2 |
| 42 |
9104494 | HIV and human endogenous retroviruses: an hypothesis with therapeutic implications. | 1996 |
1 |
| 43 |
8162567 | Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase. | 1994 May 1 |
1 |
| 44 |
8223452 | dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. | 1993 Nov |
1 |
| 45 |
1311056 | Crystal structure of a dUTPase. | 1992 Feb 20 |
1 |
| 46 |
2153555 | Cell cycle- and differentiation stage-dependent variation of dUTPase activity in higher plant cells. | 1990 Jan |
1 |
| 47 |
3025197 | Drosophila deoxyuridine triphosphatase. Purification and characterization. | 1987 Jan 5 |
1 |
| 48 |
6134653 | Isolation and characterization of the dut gene of Escherichia coli. I. Cloning in thermoinducible plasmids. | 1983 Apr |
1 |
| 49 |
6139280 | Nucleotide sequence of the structural gene for dUTPase of Escherichia coli K-12. | 1983 |
1 |
| 50 |
148458 | Escherichia coli mutants deficient in deoxyuridine triphosphatase. | 1978 Apr |
1 |