| 1 |
32000563 | A Novel Homozygous Mutation in CYP11A1 Gene is Associated with Severe Adrenal Insufficiency in 46, XX Patient. | 2021 Oct |
1 |
| 2 |
34001150 | Correlation between steroid levels in follicular fluid and hormone synthesis related substances in its exosomes and embryo quality in patients with polycystic ovary syndrome. | 2021 May 17 |
1 |
| 3 |
34015388 | Neurosteroidogenic enzymes: CYP11A1 in the central nervous system. | 2021 Jul |
1 |
| 4 |
34440620 | The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis. | 2021 Jul 22 |
1 |
| 5 |
32203088 | Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders. | 2020 May |
1 |
| 6 |
32867102 | Characterization of Two Novel Variants of the Steroidogenic Acute Regulatory Protein Identified in a Girl with Classic Lipoid Congenital Adrenal Hyperplasia. | 2020 Aug 27 |
1 |
| 7 |
33193082 | STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association. | 2020 |
1 |
| 8 |
33659272 | CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D. | 2020 |
2 |
| 9 |
30272820 | Polycistronic expression of the mitochondrial steroidogenic P450scc system in the HEK293T cell line. | 2019 Mar |
2 |
| 10 |
30348838 | Inner Mitochondrial Translocase Tim50 Is Central in Adrenal and Testicular Steroid Synthesis. | 2019 Jan 1 |
1 |
| 11 |
30641046 | Ile351, Leu355 and Ile461 residues are essential for catalytic activity of bovine cytochrome P450scc (CYP11A1). | 2019 Mar |
2 |
| 12 |
31051467 | Deficient pregnenolone synthesis associated with congenital adrenal hyperplasia and organelle dysfunction. | 2019 May 3 |
1 |
| 13 |
31741382 | Quantum-Mechanical/Molecular-Mechanical Studies of CYP11A1-Catalyzed Biosynthesis of Pregnenolone from Cholesterol Reveal a C-C Bond Cleavage Reaction That Occurs by a Compound I-Mediated Electron Transfer. | 2019 Dec 26 |
2 |
| 14 |
29228121 | Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells. | 2018 Feb 1 |
1 |
| 15 |
29566165 | Leydig cells: formation, function, and regulation. | 2018 Jul 1 |
1 |
| 16 |
29995203 | Heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A1) can cause transient adrenal insufficiency and life-threatening failure to thrive. | 2018 Sep |
1 |
| 17 |
30196001 | Elucidation of endocrine-disrupting polychlorinated biphenyls binding potency with steroidogenic genes: Integration of in silico methods and ensemble docking approaches. | 2018 Dec 15 |
2 |
| 18 |
30233493 | Aberrant Splicing Is the Pathogenicity Mechanism of the p.Glu314Lys Variant in CYP11A1 Gene. | 2018 |
1 |
| 19 |
26960203 | Disorders in the initial steps of steroid hormone synthesis. | 2017 Jan |
2 |
| 20 |
29143658 | A key enzyme of animal steroidogenesis can function in plants enhancing their immunity and accelerating the processes of growth and development. | 2017 Nov 14 |
2 |
| 21 |
29163791 | Abnormal CYP11A1 gene expression induces excessive autophagy, contributing to the pathogenesis of preeclampsia. | 2017 Oct 27 |
1 |
| 22 |
27571509 | Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1. | 2016 Sep 21 |
1 |
| 23 |
27855232 | Novel SCC mutation in a patient of Mexican descent with sex reversal, salt-losing crisis and adrenal failure. | 2016 |
1 |
| 24 |
31968797 | Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins. | 2016 Sep |
3 |
| 25 |
25448732 | Novel activities of CYP11A1 and their potential physiological significance. | 2015 Jul |
1 |
| 26 |
25988614 | On the role of skin in the regulation of local and systemic steroidogenic activities. | 2015 Nov |
1 |
| 27 |
26603348 | Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. | 2015 Dec 8 |
5 |
| 28 |
24280213 | De novo synthesis of steroids and oxysterols in adipocytes. | 2014 Jan 10 |
1 |
| 29 |
24760842 | Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration. | 2014 Apr 23 |
1 |
| 30 |
25525990 | Pregnenolone functions in centriole cohesion during mitosis. | 2014 Dec 18 |
1 |
| 31 |
25654062 | Congenital lipoid adrenal hyperplasia. | 2014 Dec |
2 |
| 32 |
23089212 | Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents. | 2013 May 22 |
2 |
| 33 |
23246788 | Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis. | 2013 May 22 |
1 |
| 34 |
23337730 | Varied clinical presentations of seven patients with mutations in CYP11A1 encoding the cholesterol side-chain cleavage enzyme, P450scc. | 2013 Feb |
2 |
| 35 |
23639404 | The role of enzyme compartmentalization on the regulation of steroid synthesis. | 2013 Sep 7 |
1 |
| 36 |
23671259 | Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme cyp11a2. | 2013 Aug |
1 |
| 37 |
23769709 | Mitochondria and mammalian reproduction. | 2013 Oct 15 |
1 |
| 38 |
22585829 | Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. | 2012 Jul |
1 |
| 39 |
22787594 | Glia-Neuron Interactions: Neurosteroids and Epileptogenesis | 2012 |
1 |
| 40 |
22968487 | Delayed diagnosis of adrenal insufficiency in a patient with severe penoscrotal hypospadias due to two novel P450 side-change cleavage enzyme (CYP11A1) mutations (p.R360W; p.R405X). | 2012 Dec |
1 |
| 41 |
22986075 | Structure-activity relationship (SAR) analysis of a family of steroids acutely controlling steroidogenesis. | 2012 Nov |
1 |
| 42 |
23039857 | Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies. | 2012 Oct 17 |
3 |
| 43 |
23330251 | Genetic defects in pregnenolone synthesis. | 2012 Oct |
2 |
| 44 |
21051590 | The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. | 2011 Feb |
2 |
| 45 |
21159775 | Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. | 2011 Feb 18 |
1 |
| 46 |
21159840 | Partial defect in the cholesterol side-chain cleavage enzyme P450scc (CYP11A1) resembling nonclassic congenital lipoid adrenal hyperplasia. | 2011 Mar |
3 |
| 47 |
21164259 | P450 side-chain cleavage deficiency--a rare cause of congenital adrenal hyperplasia. | 2011 |
1 |
| 48 |
21439354 | Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs? | 2011 Sep 15 |
1 |
| 49 |
21526428 | Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1). | 2011 Dec |
2 |
| 50 |
21636783 | Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. | 2011 Jun 21 |
2 |