| 1 |
35601076 | Simvastatin alleviates epithelial-mesenchymal transition and oxidative stress of high glucose-induced lens epithelial cells in vitro by inhibiting RhoA/ROCK signaling. | 2022 Jun |
1 |
| 2 |
33897882 | MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer. | 2021 |
1 |
| 3 |
32210573 | Simvastatin Inhibits the Malignant Behaviors of Gastric Cancer Cells by Simultaneously Suppressing YAP and β-Catenin Signaling. | 2020 |
1 |
| 4 |
32694763 | Author Correction: Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation. | 2020 Jul 22 |
1 |
| 5 |
33597925 | Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves' Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways. | 2020 |
4 |
| 6 |
30872677 | Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation. | 2019 Mar 14 |
5 |
| 7 |
29319354 | Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension. | 2018 |
9 |
| 8 |
29604489 | Attenuation of TNF-induced neutrophil adhesion by simvastatin is associated with the inhibition of Rho-GTPase activity, p50 activity and morphological changes. | 2018 May |
1 |
| 9 |
28344327 | Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. | 2017 Mar 27 |
1 |
| 10 |
29039527 | Simvastatin inhibits the expression of stemness‑related genes and the metastatic invasion of human cancer cells via destruction of the cytoskeleton. | 2017 Dec |
1 |
| 11 |
29236027 | Simvastatin Inhibits Cell Proliferation and Migration in Human Anaplastic Thyroid Cancer. | 2017 Dec 13 |
2 |
| 12 |
27180285 | Simvastatin inhibits protein isoprenylation in the brain. | 2016 Aug 4 |
1 |
| 13 |
26207907 | Simvastatin Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition. | 2015 |
2 |
| 14 |
26451103 | Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiation. | 2015 |
3 |
| 15 |
24471776 | Simvastatin inhibits transforming growth factor-β1-induced expression of type I collagen, CTGF, and α-SMA in keloid fibroblasts. | 2014 Jan-Feb |
2 |
| 16 |
24535918 | RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. | 2014 Oct |
2 |
| 17 |
24582560 | HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. | 2014 Mar 28 |
2 |
| 18 |
25023790 | HMG-CoA reductase inhibition prior reperfusion improves reparative fibrosis post-myocardial infarction in a preclinical experimental model. | 2014 Aug 20 |
1 |
| 19 |
22451024 | Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA. | 2013 Feb |
5 |
| 20 |
23424259 | A transcriptomics-informed genetic association study identifies RHOA in simvastatin-induced low-density lipoprotein cholesterol lowering. | 2013 Feb |
1 |
| 21 |
23559002 | Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. | 2013 Apr 4 |
4 |
| 22 |
22127053 | Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells. | 2012 Feb 29 |
2 |
| 23 |
23166513 | RHOA is a modulator of the cholesterol-lowering effects of statin. | 2012 |
1 |
| 24 |
20463291 | The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle. | 2011 Mar |
2 |
| 25 |
20473500 | HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients. | 2011 Nov |
4 |
| 26 |
21052011 | Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. | 2011 Feb |
3 |
| 27 |
21844074 | Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection. | 2011 Sep 6 |
2 |
| 28 |
19786891 | Inhibitory effects of simvastatin on platelet-derived growth factor signaling in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. | 2010 Jan |
1 |
| 29 |
20378830 | 3-Hydroxymethyl coenzyme A reductase inhibition attenuates spontaneous smooth muscle tone via RhoA/ROCK pathway regulated by RhoA prenylation. | 2010 Jun |
3 |
| 30 |
19001041 | Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy. | 2009 Jan 15 |
2 |
| 31 |
17452038 | Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress. | 2008 Jan |
1 |
| 32 |
18199714 | Statin induces apoptosis and cell growth arrest in prostate cancer cells. | 2008 Jan |
1 |
| 33 |
18356691 | Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. | 2008 Mar |
1 |
| 34 |
18463201 | Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. | 2008 Aug |
1 |
| 35 |
18619957 | Statins suppress MMP2 secretion via inactivation of RhoA/ROCK pathway in pulmonary vascular smooth muscles cells. | 2008 Sep 4 |
2 |
| 36 |
18625202 | HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway. | 2008 Sep 19 |
2 |
| 37 |
18658277 | Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition. | 2008 Oct |
1 |
| 38 |
18981156 | Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. | 2008 Nov 15 |
1 |
| 39 |
17217948 | Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells. | 2007 Mar |
1 |
| 40 |
16740276 | Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA. | 2006 Sep 5 |
4 |
| 41 |
16774905 | HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. | 2006 Nov |
2 |
| 42 |
16775505 | Statins blunt thrombin-induced down-regulation of endothelial nitric oxide synthase expression in human endothelial cells. | 2006 May |
1 |
| 43 |
16858009 | Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. | 2006 Dec |
7 |
| 44 |
17075836 | RhoA-mediated, tumor necrosis factor alpha-induced activation of NF-kappaB in rheumatoid synoviocytes: inhibitory effect of simvastatin. | 2006 Nov |
2 |
| 45 |
17237547 | Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis. | 2006 |
4 |
| 46 |
15728660 | Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. | 2005 May |
2 |
| 47 |
14985071 | Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. | 2004 Mar 1 |
3 |
| 48 |
15339992 | RhoA activation mediates phosphatidylinositol 3-kinase-dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft nephropathy. | 2004 Sep |
2 |
| 49 |
12477733 | Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients. | 2003 Feb 21 |
1 |
| 50 |
12951326 | Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton. | 2003 Nov 7 |
1 |