Oxaliplatin

tumor protein p53 ; Homo sapiens







90 Article(s)
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51 24022933 [Effect of Oxaliplatin on cell cycle of hepatocellular carcinoma cell line HepG2]. 2013 Jul 1
52 24118195 Higher anti-tumour efficacy of platinum(IV) complex LA-12 is associated with its ability to bypass M-phase entry block induced in oxaliplatin-treated human colon cancer cells. 2013 Dec 1
53 22678405 The different induction mechanisms of growth arrest DNA damage inducible gene 45 β in human hepatoma cell lines. 2012 2
54 23066038 A novel evolutionarily conserved element is a general transcriptional repressor of p21WAF¹/CIP¹. 2012 Dec 1 1
55 23192191 Studies on the interaction mechanism of pyrene derivatives with human tumor-related DNA. 2012 Nov 28 3
56 20734047 Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance. 2011 Jun 1
57 20839263 Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. 2011 Jul 15 5
58 20980256 The DNA damage response pathway regulates the alternative splicing of the apoptotic mediator Bcl-x. 2011 Jan 7 2
59 20980803 Differential regulation of MMP7 in colon cancer cells resistant and sensitive to oxaliplatin-induced cell death. 2011 Jan 1 1
60 21508389 Combined KRAS and TP53 mutation status is not predictive in CAPOX-treated metastatic colorectal cancer. 2011 Apr 1
61 21623005 Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors. 2011 May 2
62 21628572 Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis. 2011 Jun 28 3
63 19728331 Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. 2010 Apr 1 1
64 19833818 Impact of p53 expression and microsatellite instability on stage III colon cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin. 2010 Apr 2
65 20128802 Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors. 2010 Mar 3
66 20354524 Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa. 2010 Apr 13 2
67 20708607 Oxaliplatin down-regulates survivin by p38 MAP kinase and proteasome in human colon cancer cells. 2010 Dec 5 4
68 19015155 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. 2009 Jan 4
69 19247656 Polymorphisms in p53, GSTP1 and XRCC1 predict relapse and survival of gastric cancer patients treated with oxaliplatin-based adjuvant chemotherapy. 2009 Oct 2
70 19266094 The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin. 2009 5
71 19328230 Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation. 2009 Jun 15 1
72 19581934 Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells. 2009 Sep 3 5
73 19723892 Prostate-derived factor--a novel inhibitor of drug-induced cell death in colon cancer cells. 2009 Sep 1
74 19735649 Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells. 2009 Dec 10 7
75 18345033 P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells. 2008 Jul 10 6
76 18508032 Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines. 2008 Jul 1 1
77 17237273 The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. 2007 Jan 1
78 17343830 Inhibition of G1/S transition potentiates oxaliplatin-induced cell death in colon cancer cell lines. 2007 Jun 1 2
79 17559811 p53 dependent and independent sensitivity to oxaliplatin of colon cancer cells. 2007 Aug 1 8
80 18025273 Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo. 2007 Nov 2
81 17045763 Opposing securin and p53 protein expression in the oxaliplatin-induced cytotoxicity of human colorectal cancer cells. 2006 Dec 1 9
82 16204068 Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer. 2005 Oct 1 2
83 16227409 Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells. 2005 Oct 3
84 14985457 Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect. 2004 Feb 3
85 15041737 Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. 2004 Mar 15 6
86 15334062 Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA. 2004 Sep 30 1
87 15545975 Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells. 2004 Nov 29 1
88 12570658 Mechanisms controlling sensitivity to platinum complexes: role of p53 and DNA mismatch repair. 2003 Feb 1
89 12684687 The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells. 2003 May 1
90 12499281 Chemoradiation of cervical cancer cells: targeting human papillomavirus E6 and p53 leads to either augmented or attenuated apoptosis depending on the platinum carrier ligand. 2002 Dec 15 2