pifithrin

tumor protein p53 ; Homo sapiens







240 Article(s)
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101 24789349 The Fanconi anemia pathway sensitizes to DNA alkylating agents by inducing JNK-p53-dependent mitochondrial apoptosis in breast cancer cells. 2014 Jul 2
102 24841907 Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells. 2014 Jun 11 1
103 24905957 Signalling pathways involved in antitumoral effects of VIP in human renal cell carcinoma A498 cells: VIP induction of p53 expression. 2014 Aug 1
104 24946211 Mitochondrial protein cyclophilin-D-mediated programmed necrosis attributes to berberine-induced cytotoxicity in cultured prostate cancer cells. 2014 Jul 18 1
105 24952138 Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations. 2014 Sep 1
106 25019212 Betulinic acid-induced cytotoxicity in human breast tumor cell lines MCF-7 and T47D and its modification by tocopherol. 2014 Oct 1
107 25085902 Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53. 2014 Oct 2
108 25118938 Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells. 2014 Aug 14 1
109 25158131 p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron. 2014 Nov 1 1
110 25205311 Inhibition of mitochondrial p53 abolishes the detrimental effects of social isolation on ischemic brain injury. 2014 Oct 1
111 25379568 VorinostatSAHA Promotes Hyper-Radiosensitivity in Wild Type p53 Human Glioblastoma Cells. 2014 Jan 15 1
112 25495224 Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. 2014 Dec 12 1
113 26579413 ETME, a novel β-elemene derivative, synergizes with arsenic trioxide in inducing apoptosis and cell cycle arrest in hepatocarcinoma cells via a p53-dependent pathway. 2014 Dec 1
114 26629941 Overexpression of SMAR1 Enhances Radiosensitivity in Human Breast Cancer Cell Line MCF7 via Activation of p53 Signaling Pathway. 2014 3
115 21887816 Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray. 2013 Nov 1
116 22860893 Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway. 2013 Mar 1
117 22976055 The novel p53-dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells. 2013 Aug 3
118 22983795 p53 contributes to quercetin-induced apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. 2013 Apr 2
119 23201752 MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma. 2013 Mar 1 1
120 23349842 Homocysteine inhibits hepatocyte proliferation via endoplasmic reticulum stress. 2013 1
121 23535401 Crotonaldehyde induces apoptosis in alveolar macrophages through intracellular calcium, mitochondria and p53 signaling pathways. 2013 1
122 23640975 PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer. 2013 Jul 15 1
123 23648290 Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: relevance of p53 and its clinical implications. 2013 Aug 1
124 23652278 OSU-03012, a non-Cox inhibiting celecoxib derivative, induces apoptosis of human esophageal carcinoma cells through a p53/Bax/cytochrome c/caspase-9-dependent pathway. 2013 Aug 1
125 23816816 Casticin induces human glioma cell death through apoptosis and mitotic arrest. 2013 1
126 23859040 Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. 2013 1
127 24059678 Radiation enhances the invasiveness of irradiated and nonirradiated bystander hepatoma cells through a VEGF-MMP2 pathway initiated by p53. 2013 Oct 2
128 24179522 Pro-apoptotic and migration-suppressing potential of EGCG, and the involvement of AMPK in the p53-mediated modulation of VEGF and MMP-9 expression. 2013 Nov 1
129 22283740 P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK. 2012 Mar 1
130 22387547 XPD could suppress growth of HepG2.2.15 and down-regulate the expression of hepatitis B virus x protein through P53 pathway. 2012 Mar 23 2
131 22445757 The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells. 2012 Apr 13 2
132 22491426 Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. 2012 Jun 2
133 22519734 Expression of the polyalanine expansion mutant of nuclear poly(A)-binding protein induces apoptosis via the p53 pathway. 2012 Aug 1 1
134 22815878 Increased autophagy in placentas of intrauterine growth-restricted pregnancies. 2012 1
135 22886373 Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes. 2012 Dec 1
136 23300887 Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53. 2012 1
137 25049533 Pro-apoptotic Effect of Pifithrin-α on Preimplantation Porcine In vitro Fertilized Embryo Development. 2012 Dec 1
138 21130866 Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. 2011 Mar 15 2
139 21163271 Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. 2011 Feb 14 1
140 21212516 Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways. 2011 1
141 21266543 Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features. 2011 Feb 1
142 21274377 Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis. 2011 Jan 28 3
143 21324703 Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. 2011 Mar 1 2
144 21372157 Drawing to a Diamond flush. 2011 Mar 3 1
145 21715570 DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis. 2011 Nov 2
146 21859809 Monocyte chemoattractant protein-1 induces endothelial cell apoptosis in vitro through a p53-dependent mitochondrial pathway. 2011 Oct 2
147 21889606 Study on X-ray-induced apoptosis and chromosomal damage in G2 human lymphocytes in the presence of pifithrin-α, an inhibitor of p53. 2011 Nov 27 1
148 22041910 High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α. 2011 2
149 22044530 2,3,7,8-Tetrachlorodibenzo-p-dioxin's suppression of 1-nitropyrene-induced p53 expression is mediated by cytochrome P450 1A1. 2011 Dec 19 2
150 22260024 [Involvement of p38-p53 signal pathway in resveratrol-induced apoptosis in MCF-7 cells]. 2011 Nov 1