Decitabine

tumor protein p53 ; Homo sapiens







68 Article(s)
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51 19638426 IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. 2010 Mar 1
52 19859801 Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer. 2010 Aug 2
53 19159630 Possible involvement of activation of P53/P21 and demethylation of RUNX 3 in the cytotoxicity against Lovo cells induced by 5-Aza-2'-deoxycytidine. 2009 Feb 27 1
54 19179467 Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. 2009 Apr 30 1
55 19233506 Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells. 2009 Nov 1
56 19363521 DNA methylation inhibits p53-mediated survivin repression. 2009 May 14 1
57 17977830 An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. 2008 Feb 1 2
58 18608210 5-Aza-2'-deoxycytidine restores proapoptotic function of p53 in cancer cells resistant to p53-induced apoptosis. 2008 Aug 3
59 19010910 p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in myelodysplastic syndrome/acute myelogenous leukemia. 2008 Nov 15 3
60 15609309 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. 2005 May 1 1
61 16025287 TP53 promoter methylation in human gliomas. 2005 Aug 2
62 16131836 DNA methyltransferase-3a interacts with p53 and represses p53-mediated gene expression. 2005 Oct 2
63 14722112 5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation. 2004 Apr 9 1
64 15273730 5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells. 2004 Sep 2 6
65 12700649 Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma. 2003 Feb 1
66 11259619 Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine. 2001 Apr 1
67 11306450 p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. 2001 Apr 1 1
68 11092975 Trans-regulated silencing and reactivation of TP53 tumor suppressor gene in malignant transformation and its reversion. 2000 Nov 1