Fluorouracil

tumor protein p53 ; Homo sapiens







354 Article(s)
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151 21109480 p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. 2011 Jan 1
152 21205083 Clinical usefulness of mitochondrial transcription factor A expression as a predictive marker in colorectal cancer patients treated with FOLFOX. 2011 Mar 1
153 21479885 Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation. 2011 Dec 2
154 21514041 Gene expression signature of TP53 but not its mutation status predicts response to sequential paclitaxel and 5-FU/epirubicin/cyclophosphamide in human breast cancer. 2011 Aug 28 1
155 21561866 Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress. 2011 Jul 1 1
156 21629658 Calbindin 2 (CALB2) regulates 5-fluorouracil sensitivity in colorectal cancer by modulating the intrinsic apoptotic pathway. 2011 1
157 21674128 DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status. 2011 Sep 8
158 21709442 The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo. 2011 Jul 15 1
159 21887339 The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells. 2011 2
160 22233820 Relationship between thymidylate synthase and p53 and response to FEC versus taxane adjuvant chemotherapy for breast carcinoma. 2011 Dec 2
161 22312705 MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins. 2011 Dec 2
162 19585117 Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. 2010 Feb 1
163 19810096 Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5-fluorouracil in colorectal cancer. 2010 Apr 1 9
164 19941080 p53 genotype predicts response to chemotherapy in patients with squamous cell carcinoma of the esophagus. 2010 Feb 1
165 20048189 TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma. 2010 Feb 10 1
166 20107315 MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil. 2010 Apr 1 1
167 20354524 Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa. 2010 Apr 13 2
168 20367642 TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis. 2010 Jul 8
169 20368736 BNIP3 is essential for mediating 6-thioguanine- and 5-fluorouracil-induced autophagy following DNA mismatch repair processing. 2010 Jun 2
170 20422012 The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound. 2010 Apr 21 2
171 20514446 Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroids. 2010 Jul 2
172 20633010 Low-dose 5-fluorouracil induces cell cycle G2 arrest and apoptosis in keloid fibroblasts. 2010 Dec 1
173 20638924 Distribution of TYMS, MTHFR, p53 and MDR1 gene polymorphisms in patients with breast cancer treated with neoadjuvant chemotherapy. 2010 Oct 1
174 20704765 LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. 2010 Aug 13 2
175 20716879 [Microarray analysis of tumor xenograft model]. 2010 Aug 1
176 21036698 5-fluorouracil-induced death of Jurkat T-cells--a role for caspases and MCL-1. 2010 Oct 2
177 19097688 Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. 2009 Apr 18 2
178 19150257 HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53. 2009 Mar 1 2
179 19155291 Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence. 2009 Feb 1 2
180 19270508 Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed. 2009 May 1
181 19542220 Mirk regulates the exit of colon cancer cells from quiescence. 2009 Aug 21 1
182 19605487 Hepatitis C virus core protein and cellular protein HAX-1 promote 5-fluorouracil-mediated hepatocyte growth inhibition. 2009 Oct 4
183 19661313 Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation. 2009 Aug 6
184 19723892 Prostate-derived factor--a novel inhibitor of drug-induced cell death in colon cancer cells. 2009 Sep 1
185 19731257 The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein. 2009 Nov 2
186 19923910 The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells. 2009 Nov 2
187 19954513 Identification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy. 2009 Dec 2 7
188 17637740 Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells. 2008 Jan 31 2
189 17698398 Cyr61/CCN1 is a tumor suppressor in human hepatocellular carcinoma and involved in DNA damage response. 2008 2
190 17982488 Wild-type p53 and p73 negatively regulate expression of proliferation related genes. 2008 Apr 17 1
191 18191509 Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer. 2008 Apr 2 1
192 18325917 p53 status and efficacy of primary anthracyclines/alkylating agent-based regimen according to breast cancer molecular classes. 2008 Jul 1
193 18357466 Prognostic role of p53 codon 72 polymorphism in gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy. 2008 Oct 5
194 18377724 CSE1L/CAS, a microtubule-associated protein, inhibits taxol (paclitaxel)-induced apoptosis but enhances cancer cell apoptosis induced by various chemotherapeutic drugs. 2008 Mar 31 1
195 18497562 Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. 2008 Aug 4
196 18497992 Mechanism of resistance to chemoradiation in p53 mutant human colon cancer. 2008 Jun 2
197 18498133 Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival. 2008 Aug 1 1
198 18600534 Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells. 2008 Jun 1
199 18779317 p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. 2008 Nov 3
200 18834353 Effect of Bupleuri Radix extracts on the toxicity of 5-fluorouracil in HepG2 hepatoma cells and normal human lymphocytes. 2008 Oct 1