Cisplatin

tumor protein p53 ; Homo sapiens







886 Article(s)
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801 10589764 TP53 accumulation predicts improved survival in patients resistant to systemic cisplatin-based chemotherapy for muscle-invasive bladder cancer. 1999 Nov 1
802 10615232 Bcl-2 as a predictor of chemosensitivity and prognosis in primary epithelial ovarian cancer. 1999 Aug 1
803 10626356 Role of p53 in the ability of 1,2-diaminocyclohexane-diacetato-dichloro-Pt(IV) to circumvent cisplatin resistance. 1999 Oct 2
804 10632346 Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer. 1999 Dec 1
805 10665656 Cisplatin-resistant HeLa cells are resistant to apoptosis via p53-dependent and -independent pathways. 1999 Dec 3
806 10674873 Mdm2 sensitizes MCF7 breast cancer cells to cisplatin or carboplatin. 1999 Nov 3
807 10697522 De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. 1999 Nov-Dec 6
808 9455805 Inactivation of p53 in normal human cells increases G2/M arrest and sensitivity to DNA-damaging agents. 1998 Jan 30 1
809 9458352 Role of p53 and apoptosis in sensitization of cis-diamminedichloroplatinum antitumor activity by interleukin-1 in ovarian carcinoma cells. 1998 Feb 3
810 9474928 [Molecular therapy for human cancer with tumor suppressor p53 gene transfer]. 1998 Jan 1
811 9485023 Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line. 1998 Feb 15 7
812 9498829 In vivo influence of p53 status on proliferation and chemoradiosensitivity in non-small-cell lung cancer. 1998 Jan 1
813 9506540 Acute overexpression of wt p53 facilitates anticancer drug-induced death of cancer and normal cells. 1998 Mar 16 1
814 9508372 Chemotherapy-induced apoptosis in melanoma cells is p53 dependent. 1998 Feb 2
815 9548450 Absence of p53 overexpression and favorable response to cisplatin-based neoadjuvant chemotherapy in urothelial carcinomas. 1998 Feb 1
816 9584207 Cisplatin- and paclitaxel-induced apoptosis of ovarian carcinoma cells and the relationship between bax and bak up-regulation and the functional status of p53. 1998 May 3
817 9607592 Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity. 1998 May 1
818 9619834 mdm2-P2 transcript levels predict the functional activity of the p53 tumor suppressor in primary leukemic cells. 1998 Apr 30 1
819 9620551 Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation. 1998 May 7 2
820 9635829 Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines. 1998 May 4
821 9636834 Ovarian cancer cisplatin-resistant cell lines: multiple changes including collateral sensitivity to Taxol. 1998 Apr 1
822 9652752 Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells. 1998 May 1
823 9664115 The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells. 1998 Aug 1
824 9681825 Mutant p53 protein expression interferes with p53-independent apoptotic pathways. 1998 Jun 25 1
825 9698467 Lisofylline sensitizes p53 mutant human ovarian carcinoma cells to the cytotoxic effects of cis-diamminedichloroplatinum (II). 1998 Jul 5
826 9700726 DNA binding activities of p53 protein following cisplatin damage of ovarian cells. 1998 8
827 9703286 Therapy effect of either paclitaxel or cyclophosphamide combination treatment in patients with epithelial ovarian cancer and relation to TP53 gene status. 1998 Aug 2
828 9713515 Enhancement of chemosensitivity in human bladder cancer cells by adenoviral-mediated p53 gene transfer. 1998 Jul-Aug 1
829 9713990 Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system. 1998 Sep 2
830 9731490 Ionizing radiation inhibits chemotherapy-induced apoptosis in cultured glioma cells: implications for combined modality therapy. 1998 Sep 1 2
831 9772293 Cell cycle arrest in ovarian cancer cell lines does not depend on p53 status upon treatment with cytostatic drugs. 1998 Nov 1
832 9788435 Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs. 1998 Oct 15 1
833 9811465 Human lymphoblastoid cell lines expressing mutant p53 exhibit decreased sensitivity to cisplatin-induced cytotoxicity. 1998 Nov 5 10
834 9837785 Levels of p53 in Epstein-Barr virus-infected cells determine cell fate: apoptosis, cell cycle arrest at the G1/S boundary without apoptosis, cell cycle arrest at the G2/M boundary without apoptosis, or unrestricted proliferation. 1998 Nov 25 1
835 9893672 A newly developed adenovirus-mediated transfer of a wild-type p53 gene increases sensitivity to cis-diamminedichloroplatinum (II) in p53-deleted ovarian cancer cells. 1998 Oct 3
836 9951689 Complete sequence of p53 gene in 20 patients with lung cancer: comparison with chemosensitivity and immunohistochemistry. 1998 Dec 1
837 10081494 EAT/mcl-1, a member of the bcl-2 related genes, confers resistance to apoptosis induced by cis-diammine dichloroplatinum (II) via a p53-independent pathway. 1998 Dec 2
838 9010220 Identification of p53 genetic suppressor elements which confer resistance to cisplatin. 1997 Jan 16 4
839 9013707 The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. 1997 Jan 10 4
840 9174048 Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard. 1997 May 8 3
841 9186003 Down-regulation of cyclin A gene expression upon genotoxic stress correlates with reduced binding of free E2F to the promoter. 1997 Jun 1
842 9212237 Mechanism of resistance to cisplatin in a human ovarian-carcinoma cell line selected for resistance to doxorubicin: possible role of p53. 1997 Jul 3 5
843 9291435 mdm 2 mRNA expression is associated with survival in ovarian cancer. 1997 Aug 22 3
844 9312058 Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53. 1997 Oct 1 1
845 9323493 Changes in levels of expression of p53 and the product of the bcl-2 in lines of gastric cancer cells during cisplatin-induced apoptosis. 1997 4
846 9359484 Novel combination therapy for human colon cancer with adenovirus-mediated wild-type p53 gene transfer and DNA-damaging chemotherapeutic agent. 1997 Nov 4 1
847 9374378 Reduced expression of the ICE-related protease CPP32 is associated with radiation-induced cisplatin resistance in HeLa cells. 1997 1
848 9389577 Lack of correlation between cisplatin-induced apoptosis, p53 status and expression of Bcl-2 family proteins in testicular germ cell tumour cell lines. 1997 Nov 14 2
849 9403032 Modulation of NF-kappa B, and Bcl-2 in apoptosis induced by cisplatin in HeLa cells. 1997 Nov 19 1
850 9413185 Mechanism of apoptosis induced by cisplatin and VP-16 in PANC-1 cells. 1997 Sep-Oct 1