| 51 |
15475000 | GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression. | 2004 Nov 1 |
1 |
| 52 |
15475475 | High-content screening with siRNA optimizes a cell biological approach to drug discovery: defining the role of P53 activation in the cellular response to anticancer drugs. | 2004 Oct |
3 |
| 53 |
15492260 | Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents. | 2004 Oct 15 |
1 |
| 54 |
15505424 | Activation of multidomain and BH3-only pro-apoptotic Bcl-2 family members in p53-defective cells. | 2004 Nov |
1 |
| 55 |
15724841 | Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01. | 2004 Oct |
1 |
| 56 |
12538580 | Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition. | 2003 Mar 28 |
1 |
| 57 |
12684687 | The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells. | 2003 May |
1 |
| 58 |
12721303 | Calpains mediate p53 activation and neuronal death evoked by DNA damage. | 2003 Jul 11 |
1 |
| 59 |
12807744 | Hypoxia induces p53 through a pathway distinct from most DNA-damaging and stress-inducing agents. | 2003 Jul |
1 |
| 60 |
14583781 | c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis. | 2003 Nov 3 |
5 |
| 61 |
12036943 | Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteins. | 2002 Jun 1 |
1 |
| 62 |
12048243 | Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. | 2002 Jun 11 |
1 |
| 63 |
11313865 | p53 protein accumulation in addition to the transactivation activity is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin. | 2001 Mar 8 |
4 |
| 64 |
11313933 | Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. | 2001 Apr 5 |
1 |
| 65 |
11418138 | pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. | 2001 Jun 15 |
1 |
| 66 |
11423970 | Activation of p53 by roscovitine-mediated suppression of MDM2 expression. | 2001 May 31 |
1 |
| 67 |
11438577 | Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage. | 2001 Jul 15 |
1 |
| 68 |
11457508 | Downregulation of free ubiquitin: a novel mechanism of p53 stabilization and neuronal cell death. | 2001 Jul 13 |
1 |
| 69 |
11591730 | APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. | 2001 Oct 15 |
3 |
| 70 |
11593403 | Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation. | 2001 Sep 20 |
1 |
| 71 |
11741290 | Camptothecin and Zeocin can increase p53 levels during all cell cycle stages. | 2001 Dec 21 |
4 |
| 72 |
10644891 | p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells. | 2000 Jan-Feb |
1 |
| 73 |
10663644 | Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest. | 2000 |
1 |
| 74 |
10692111 | p53-dependent apoptosis in melanoma cells after treatment with camptothecin. | 2000 Mar |
3 |
| 75 |
10749144 | A DNA damage signal is required for p53 to activate gadd45. | 2000 Mar 15 |
2 |
| 76 |
10757806 | Stress signals utilize multiple pathways to stabilize p53. | 2000 May |
1 |
| 77 |
10891498 | MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M. | 2000 Aug |
1 |
| 78 |
11023999 | The Werner syndrome protein contributes to induction of p53 by DNA damage. | 2000 Nov |
1 |
| 79 |
11029511 | UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells. | 2000 Nov |
3 |
| 80 |
11054676 | Oncolytic potential of E1B 55 kDa-deleted YKL-1 recombinant adenovirus: correlation with p53 functional status. | 2000 Nov 1 |
1 |
| 81 |
11205246 | Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines. | 2000 Nov-Dec |
1 |
| 82 |
10455888 | Inhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways. | 1999 Aug |
1 |
| 83 |
10523305 | Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo. | 1999 Oct 15 |
1 |
| 84 |
10536167 | Differences in induction of p53, p21WAF1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin. | 1999 Nov |
3 |
| 85 |
10585266 | Accumulation of mutant p53(V143A) modulates the growth, clonogenicity, and radiochemosensitivity of malignant glioma cells independent of endogenous p53 status. | 1999 Dec 15 |
4 |
| 86 |
9499438 | Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways. | 1998 Apr |
1 |
| 87 |
9508372 | Chemotherapy-induced apoptosis in melanoma cells is p53 dependent. | 1998 Feb |
3 |
| 88 |
9660477 | Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors. | 1998 Jul |
1 |
| 89 |
9673414 | Role of wild-type p53 in the enhancement of camptothecin cytotoxicity against human prostate tumor cells. | 1998 May-Jun |
3 |
| 90 |
9743293 | Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors. | 1998 Sep |
1 |
| 91 |
9794234 | Dexamethasone-mediated protection from drug cytotoxicity: association with p21WAF1/CIP1 protein accumulation? | 1998 Sep 24 |
1 |
| 92 |
9878214 | The topoisomerase I inhibitors, camptothecin and beta-lapachone, induce apoptosis of human retinal pigment epithelial cells. | 1998 Nov |
2 |
| 93 |
9264376 | Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases. | 1997 Aug |
1 |
| 94 |
9307289 | Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. | 1997 Sep 15 |
3 |
| 95 |
9398050 | Topoisomerase-I inhibitors for human malignant glioma: differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and beta-lapachone. | 1997 Nov 27 |
1 |
| 96 |
9815856 | Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells. | 1997 Sep |
1 |
| 97 |
8639538 | Modulation of DNA topoisomerase I activity by p53. | 1996 May 7 |
1 |
| 98 |
8806433 | DNA fragmentation induced by protease activation in p53-null human leukemia HL60 cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: cell-free system studies. | 1996 Aug 1 |
2 |
| 99 |
8875976 | p53 N-terminus-targeted protein kinase activity is stimulated in response to wild type p53 and DNA damage. | 1996 Oct 3 |
1 |
| 100 |
8938795 | Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. | 1996 |
1 |