| 51 |
27274280 | Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway. | 2016 |
11 |
| 52 |
25131770 | SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma. | 2015 Jan |
3 |
| 53 |
25495168 | The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome--a proof-of-concept study. | 2015 Apr |
3 |
| 54 |
25505174 | Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer. | 2015 Jan 23 |
3 |
| 55 |
25955843 | Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells. | 2015 |
1 |
| 56 |
26196392 | Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo. | 2015 |
2 |
| 57 |
26225749 | p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. | 2015 Sep 4 |
12 |
| 58 |
26383681 | Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy. | 2015 Oct 1 |
1 |
| 59 |
26599019 | Metformin Radiosensitizes p53-Deficient Colorectal Cancer Cells through Induction of G2/M Arrest and Inhibition of DNA Repair Proteins. | 2015 |
5 |
| 60 |
26629991 | Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway. | 2015 |
1 |
| 61 |
26677765 | Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation. | 2015 Dec 8 |
1 |
| 62 |
26885449 | Metformin inhibits salivary adenocarcinoma growth through cell cycle arrest and apoptosis. | 2015 |
2 |
| 63 |
23999197 | Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression. | 2014 May |
1 |
| 64 |
24190973 | AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. | 2014 Jan |
1 |
| 65 |
24504677 | Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery. | 2014 Jun |
1 |
| 66 |
24970682 | Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. | 2014 Sep |
8 |
| 67 |
22773548 | Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. | 2013 Apr |
1 |
| 68 |
23303309 | Oxidants, antioxidants and the current incurability of metastatic cancers. | 2013 Jan 8 |
1 |
| 69 |
23620761 | Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners. | 2013 |
2 |
| 70 |
23632475 | Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. | 2013 May 28 |
1 |
| 71 |
23891087 | Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin. | 2013 Sep |
5 |
| 72 |
23982736 | Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway. | 2013 Nov |
5 |
| 73 |
24335168 | Metformin inhibits esophagus cancer proliferation through upregulation of USP7. | 2013 |
1 |
| 74 |
22090360 | TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. | 2012 Jan 1 |
3 |
| 75 |
22378745 | A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. | 2012 Jul 1 |
3 |
| 76 |
22442140 | Metformin, metabolic stress, and mitochondria. Focus on "A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells". | 2012 Jul 1 |
1 |
| 77 |
21540236 | Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. | 2011 Jul 1 |
3 |
| 78 |
21655990 | Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. | 2011 Aug |
2 |
| 79 |
21776823 | Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. | 2011 |
4 |
| 80 |
20215500 | Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. | 2010 Mar 15 |
4 |
| 81 |
17638885 | Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. | 2007 Jul 15 |
9 |