Glutathione

tumor protein p53 ; Homo sapiens







58 Article(s)
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1 35074928 Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity. 2022 Apr 2
2 33594332 Role of ferroptosis in the process of diabetes-induced endothelial dysfunction. 2021 Feb 15 1
3 33927351 Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity. 2021 May 1
4 32318262 Integrated analysis of transcriptomic and metabolomic profiling reveal the p53 associated pathways underlying the response to ionizing radiation in HBE cells. 2020 1
5 32801360 Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF. 2020 Aug 14 1
6 32925794 Identification of MTHFD2 as a novel prognosis biomarker in esophageal carcinoma patients based on transcriptomic data and methylation profiling. 2020 Sep 11 1
7 33055209 Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53. 2020 Oct 27 2
8 33361854 CHANGES IN GENE EXPRESSION ASSOCIATED WITH NON-CANCER EFFECTS OF THE CHORNOBYL CLEAN-UP WORKERS IN THE REMOTE PERIOD AFTER EXPOSURE. 2020 Dec 1
9 30414976 Andrographolide enhances redox status of liver cells by regulating microRNA expression. 2019 Jan 1
10 30554018 Redox-responsive polymer inhibits macrophages uptake for effective intracellular gene delivery and enhanced cancer therapy. 2019 Mar 1 4
11 30755224 PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level. 2019 Feb 12 3
12 31605953 Dual roles of glutathione S-transferase mu 1 in the development and metastasis of hepatocellular carcinoma. 2019 Dec 1
13 32010620 Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells. 2019 1
14 29346757 p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. 2018 Jan 16 1
15 29702192 Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT. 2018 Aug 1 1
16 29887958 Analysis of differentially expressed genes, clinical value and biological pathways in prostate cancer. 2018 1
17 28012015 Modulation of cell death in human colorectal and breast cancer cells through a manganese chelate by involving GSH with intracellular p53 status. 2017 Mar 6
18 28348409 Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation. 2017 Mar 28 4
19 29057306 Inhibiting system xC- and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers. 2017 2
20 26599622 A surface charge-switchable and folate modified system for co-delivery of proapoptosis peptide and p53 plasmid in cancer therapy. 2016 Jan 2
21 27031930 Fabrication of dual responsive co-delivery system based on three-armed peptides for tumor therapy. 2016 Jun 1
22 24507760 Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer. 2014 Feb 8 1
23 24632713 Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death. 2014 May 8 2
24 24913304 A cisplatin-resistant head and neck cancer cell line with cytoplasmic p53(mut) exhibits ATP-binding cassette transporter upregulation and high glutathione levels. 2014 Oct 2
25 22861165 p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance. 2013 Feb 1 1
26 23242140 Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. 2013 Jan 24 1
27 23395165 The Hunger Games: p53 regulates metabolism upon serine starvation. 2013 Feb 5 1
28 24012792 E6 protein of human papillomavirus 16 (HPV16) expressed in Escherichia coli sans a stretch of hydrophobic amino acids, enables purification of GST-ΔE6 in the soluble form and retains the binding ability to p53. 2013 Nov 1
29 22607092 P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells. 2012 Sep 3
30 22644859 Effects of geranyl-phloroacetophenone on the induction of apoptosis and chemosensitization of adriamycin-resistant MCF-7 human breast cancer cells. 2012 May 1
31 21411502 Targeting p53-null neuroblastomas through RLIP76. 2011 Jun 9
32 21669188 Glutathione selectively inhibits Doxorubicin induced phosphorylation of p53Ser¹⁵, caspase dependent ceramide production and apoptosis in human leukemic cells. 2011 Jul 22 2
33 20351271 Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. 2010 Apr 20 3
34 20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. 2010 Apr 20 1
35 20816748 C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site. 2010 Nov 15 1
36 19202565 Molecular mechanism of diallyl disulfide in cell cycle arrest and apoptosis in HCT-116 colon cancer cells. 2009 Jan-Feb 1
37 18045546 Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation. 2008 Jan 1 3
38 17332940 Arsenic trioxide induces p53-dependent apoptotic signals in myeloma cells with SiRNA-silenced p53: MAP kinase pathway is preferentially activated in cells expressing inactivated p53. 2007 Apr 1
39 17443686 Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest. 2007 Sep 4
40 17555331 Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress. 2007 Jul 3 4
41 15814660 Tirapazamine cytotoxicity for neuroblastoma is p53 dependent. 2005 Apr 1 2
42 15842803 [In vitro binding of p53 and telomeric repeat factor 2]. 2005 Feb 1
43 15302882 Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes. 2004 Oct 29 1
44 12663048 Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity. 2003 Apr 1 1
45 12807757 Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein. 2003 Aug 1
46 12967322 Ceramide and glutathione define two independently regulated pathways of cell death initiated by p53 in Molt-4 leukaemia cells. 2003 Dec 15 2
47 14555710 Transduction of green fluorescent protein increased oxidative stress and enhanced sensitivity to cytotoxic drugs in neuroblastoma cell lines. 2003 Sep 3
48 12160929 Possible involvement of glutathione and p53 in trichloroethylene- and perchloroethylene-induced lipid peroxidation and apoptosis in human lung cancer cells. 2002 Aug 15 3
49 12376468 Reporter gene transactivation by human p53 is inhibited in thioredoxin reductase null yeast by a mechanism associated with thioredoxin oxidation and independent of changes in the redox state of glutathione. 2002 Oct 2
50 11477076 High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53. 2001 Oct 5 2