Quinacrine

tumor protein p53 ; Homo sapiens







15 Article(s)
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1 35460941 Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis. 2022 Jul 4
2 31562955 Repurposing quinacrine for treatment-refractory cancer. 2021 Jan 4
3 29386219 A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers. 2018 Apr 15 6
4 29545477 Therapeutic Effect of Quinacrine, an Antiprotozoan Drug, by Selective Suppression of p-CHK1/2 in p53-Negative Malignant Cancers. 2018 Jun 1
5 21544805 Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity. 2012 Apr 1 1
6 23193914 Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism. 2012 2
7 21518868 FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB. 2011 May 10 1
8 21569639 Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers. 2011 May 15 1
9 21725212 Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents. 2011 Aug 1 3
10 21725213 Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer. 2011 Aug 1 1
11 19137016 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways. 2009 Feb 26 1
12 18006756 Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer. 2007 Nov 15 8
13 16177561 Acridine derivatives activate p53 and induce tumor cell death through Bax. 2005 Aug 2
14 16287968 Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. 2005 Nov 29 2
15 12082016 High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter. 2002 Jun 1