Curcumin

tumor protein p53 ; Homo sapiens







164 Article(s)
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101 22227273 Curcumin as anti-endometriotic agent: implication of MMP-3 and intrinsic apoptotic pathway. 2012 Mar 15 1
102 22298641 Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells. 2012 Apr 3
103 22522053 Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway. 2012 Jun 1
104 22765290 Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. 2012 Oct 1
105 22910273 Synergistic anti-cancer mechanisms of curcumin and paclitaxel for growth inhibition of human brain tumor stem cells and LN18 and U138MG cells. 2012 Dec 1
106 23152782 Knockdown of Ki-67 by dicer-substrate small interfering RNA sensitizes bladder cancer cells to curcumin-induced tumor inhibition. 2012 1
107 23351311 Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells. 2012 Nov 30 2
108 20839263 Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. 2011 Jul 15 2
109 21134073 Testosterone augments polyphenol-induced DNA damage response in prostate cancer cell line, LNCaP. 2011 Feb 1
110 21167259 Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis. 2011 Feb 11 2
111 21314329 Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. 2011 Mar 3
112 21386967 Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. 2011 Feb 28 1
113 22013068 Curcumin enhances the efficacy of chemotherapy by tailoring p65NFκB-p300 cross-talk in favor of p53-p300 in breast cancer. 2011 Dec 9 1
114 19676105 Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. 2010 Jan 6
115 19944674 Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines. 2010 Feb 12 1
116 20138829 Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells. 2010 Apr 9 1
117 20472336 Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells. 2010 Nov 1 8
118 20596601 The anti-cancer efficacy of curcumin scrutinized through core signaling pathways in glioblastoma. 2010 Aug 2
119 20686221 Apoptosis of human lung cancer cells by curcumin mediated through up-regulation of "growth arrest and DNA damage inducible genes 45 and 153". 2010 1
120 21036715 Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing's sarcoma cells. 2010 Oct 7
121 19288022 Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells. 2009 Apr 1
122 19580791 Curcumin derivatives: molecular basis of their anti-cancer activity. 2009 Nov 15 1
123 19693275 Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis. 2009 Aug 20 1
124 19838927 Curcumin synergizes with resveratrol to inhibit colon cancer. 2009 2
125 17879958 Roles for CSN5 in control of p53/MDM2 activities. 2008 Mar 1 1
126 18316600 p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. 2008 Mar 1 1
127 18370854 Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. 2008 Mar 1
128 18384098 Multi-targeted therapy by curcumin: how spicy is it? 2008 Sep 1
129 18414057 Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R). 2008 Jul 1
130 18646516 [Overexpression and higher phosphorylation of p53 induced by benzo(a) pyrene through activated protein 1 independent pathway]. 2008 May 1
131 19020741 AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. 2008 Dec 1
132 17218783 Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. 2007 Feb 1
133 17240359 Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. 2007 Apr 1 1
134 17332326 Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. 2007 Mar 1 1
135 17332930 Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer. 2007 Apr 7
136 17569210 Antitumor, anti-invasion, and antimetastatic effects of curcumin. 2007 1
137 17594054 Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma. 2007 Dec 2
138 17596214 Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. 2007 Jul 1
139 16376585 Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. 2006 Mar 2
140 16787365 Curcumin is an inhibitor of p300 histone acetylatransferase. 2006 Mar 1
141 17201158 Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. 2006 Nov-Dec 1
142 15738001 Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner. 2005 May 20 5
143 15809436 Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin. 2005 Apr 12 6
144 16083495 Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells. 2005 Aug 5 1
145 16302093 Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression. 2005 Dec 6
146 16468334 [Effects of curcumin on the acetylation of histone H3, P53 and the proliferation of NB4 cells]. 2005 Sep 3
147 15090465 Curcumin impairs tumor suppressor p53 function in colon cancer cells. 2004 Sep 2
148 15140256 Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells. 2004 May 12 1
149 15142674 Induction of apoptosis in human lung cancer cells by curcumin. 2004 May 28 1
150 15161054 Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. 2004 Mar-Apr 2