Benzo(a)pyrene

tumor protein p53 ; Homo sapiens







75 Article(s)
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51 15837074 Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway. 2005 Apr 1
52 16297369 p38 MAP kinase regulates benzo(a)pyrene-induced apoptosis through the regulation of p53 activation. 2005 Dec 15 3
53 15072824 High DNA damage by benzo[a]pyrene 7,8-diol-9,10-epoxide in bronchial epithelial cells from patients with lung cancer: comparison with lung parenchyma. 2004 Apr 30 1
54 15081398 Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. 2004 May 7 1
55 15595848 Mutagenic potential of benzo[a]pyrene-derived DNA adducts positioned in codon 273 of the human P53 gene. 2004 Dec 21 1
56 12538356 Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of correspondence to tumor mutation spectra. 2003 Jan 1
57 12807757 Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein. 2003 Aug 2
58 14644313 Functional characterization of global genomic DNA repair and its implications for cancer. 2003 Nov 2
59 12507920 CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation. 2002 Dec 1
60 11522624 Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung. 2001 Sep 1 3
61 10708967 Mutagenicity of benzo[a]pyrene-deoxyadenosine adducts in a sequence context derived from the p53 gene. 2000 Feb 16 3
62 10837373 Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21. 2000 Jun 1
63 11191113 Disruption of cell cycle kinetics by benzo[a]pyrene: inverse expression patterns of BRCA-1 and p53 in MCF-7 cells arrested in S and G2. 2000 Sep-Oct 1
64 9920731 Reconstituted 3-dimensional human skin as a novel in vitro model for studies of carcinogenesis. 1999 Jan 8 1
65 10575010 Benzo[a]pyrene activates the human p53 gene through induction of nuclear factor kappaB activity. 1999 Dec 3 2
66 9468547 Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals. 1998 Mar-Apr 1
67 9472715 Immunohistochemical visualization of wild-type p53 protein in paraffin-embedded rat liver using tyramide amplification: zonal hepatic distribution of p53 protein after N-hydroxy-2-acetylaminofluorene administration. 1998 Jan 1
68 9855010 A study of multiple biomarkers in coke oven workers--a cross-sectional study in China. 1998 Nov 1
69 14646501 Crocidolite asbestos causes an induction of p53 and apoptosis in cultured A-549 lung carcinoma cells. 1998 1
70 8832894 Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. 1996 Oct 18 1
71 8895489 p53 mutations in lung tumours: relationship to gender and lung DNA adduct levels. 1996 Oct 1
72 7554063 p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. 1995 Sep 6
73 7766306 Benzo[a]pyrene-induced mutagenesis of p53 hot-spot codons 248 and 249 in human hepatocytes. 1995 May 2
74 8036011 Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. 1994 Aug 1
75 1933877 Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. 1991 Nov 15 1