Leucine

tumor protein p53 ; Homo sapiens







27 Article(s)
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1 34958576 Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein-Protein Interactions on a Cell-Penetrating Peptide Scaffold. 2022 Feb 7 1
2 30802707 Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2-p53 interaction. 2019 May 1
3 31366730 The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis. 2019 Sep 20 1
4 25098371 L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. 2014 Nov 2
5 21331782 P53 mutation is a rare event in Merkel cell carcinoma of the head and neck. 2011 Nov 1
6 19153082 Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes. 2009 Mar 27 1
7 18058229 TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFbeta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy. 2008 Nov 1
8 18707164 Quantum mechanical studies of residue-specific hydrophobic interactions in p53-MDM2 binding. 2008 Sep 11 3
9 17062352 [Prediction of the possible tertiary structure alterations of p53 protein following point mutation in p53 gene condon 282 in lung cancer cells]. 2006 Oct 2
10 15547693 Sustained gene transfer and enhanced cell death following glucosylated-PEI-mediated p53 gene transfer with photochemical internalisation in p53-mutated head and neck carcinoma cells. 2004 Dec 1
11 11925449 The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. 2002 Aug 9 2
12 12011992 Characterization of novel cell lines established from three human oral squamous cell carcinomas. 2002 Jun 1
13 12076704 A novel, de novo germline TP53 mutation in a rare presentation of the Li-Fraumeni syndrome in the maxilla. 2002 Jun 1
14 21044462 [Study on the growth of H1299 cell line transfected transiently with mouse p53 minigenes with different codon 172 structures]. 2001 Apr 20 2
15 10944184 A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53. 2000 Aug 29 2
16 11023067 p53 status and human papillomavirus infection in Thai women with cervical carcinoma. 2000 Mar 1
17 10226945 Infrequent p53 mutations in patients with areca quid chewing-associated oral squamous cell carcinomas in Taiwan. 1999 May 1
18 10449043 Common conformational effects in the p53 protein of vinyl chloride-induced mutations. 1999 May 3
19 10487521 Induction of apoptosis by the p53-273L (Arg --> Leu) mutant in HSC3 cells without transactivation of p21Waf1/Cip1/Sdi1 and bax. 1999 Sep 2
20 11601009 [Specific point-mutate p53 mini-gene transfectimg effects on biological behaviors of a human cancer cell line PG derived from human pulmonary giant carcinoma]. 1999 Jan 1
21 11245004 [A study on the tumor suppressing effect of a specific point mutant p53 minigene in the expression regulated model with a tetracycline-transactivative response promoter]. 1998 Oct 1
22 8649776 The 273rd codon mutants of p53 show growth modulation activities not correlated with p53-specific transactivation activity. 1996 Jun 6 1
23 8824527 Chromosomal abnormalities in HPV-16-immortalized oral epithelial cells. 1996 Sep 1
24 9038605 Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas. 1996 Dec 1
25 7784087 Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants. 1995 Jun 15 2
26 7926727 Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. 1994 May 15 3
27 7955057 Infrequent mutation in tumor suppressor gene p53 in gestational trophoblastic neoplasia. 1994 Oct 1