Reactive Oxygen Species

tumor protein p53 ; Homo sapiens







511 Article(s)
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251 24535669 Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. 2014 Apr 1
252 24667842 Sulforaphane induces oxidative stress and death by p53-independent mechanism: implication of impaired glutathione recycling. 2014 1
253 24714748 Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. 2014 May 13 1
254 24727577 Nuclear NF-κB contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells. 2014 May 1
255 24759730 Non-thermal atmospheric pressure plasma preferentially induces apoptosis in p53-mutated cancer cells by activating ROS stress-response pathways. 2014 1
256 24829158 The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. 2014 1
257 24831807 Interactions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells. 2014 1
258 24839208 Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. 2014 Sep 2
259 24841907 Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells. 2014 Jun 11 3
260 24859470 As a novel p53 direct target, bidirectional gene HspB2/αB-crystallin regulates the ROS level and Warburg effect. 2014 Jul 3
261 24875531 Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway. 2014 1
262 24918814 Glyoxalase I inhibition induces apoptosis in irradiated MCF-7 cells via a novel mechanism involving Hsp27, p53 and NF-κB. 2014 Jul 15 2
263 24930072 Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives. 2014 Oct 1
264 24932684 MIF family members cooperatively inhibit p53 expression and activity. 2014 2
265 24946211 Mitochondrial protein cyclophilin-D-mediated programmed necrosis attributes to berberine-induced cytotoxicity in cultured prostate cancer cells. 2014 Jul 18 1
266 24959493 Hypoxia induced DNA damage in children with isolated septal defect and septal defect with great vessel anomaly of heart. 2014 Apr 2
267 24967384 Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. 2014 3
268 25013761 p53 is a key regulator for osthole-triggered cancer pathogenesis. 2014 2
269 25064843 Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species-p53-p21Cip1/WAF1 pathway. 2014 Aug 25 2
270 25086499 Akt and p53R2, partners that dictate the progression and invasiveness of cancer. 2014 Oct 2
271 25108166 Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1α. 2014 Sep 26 1
272 25115399 Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins. 2014 Sep 30 4
273 25139326 2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53. 2014 Oct 1 13
274 25140197 Decitabine and SAHA-induced apoptosis is accompanied by survivin downregulation and potentiated by ATRA in p53-deficient cells. 2014 2
275 25217696 JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2. 2014 Nov 6 1
276 25302047 Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction. 2014 Dec 1
277 25429619 ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells. 2014 Nov 27 2
278 25448679 Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor. 2014 Nov 28 1
279 22201594 p53 regulation of energy metabolism and mitochondria regulation of p53 in cancer cells: an insight into the role of manganese superoxide dismutase. 2013 2
280 22918438 The critical role of catalase in prooxidant and antioxidant function of p53. 2013 Jan 11
281 23063463 TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities. 2013 Jan 1
282 23116945 Adipose tissue inflammation in diabetes and heart failure. 2013 Jan 1
283 23124852 Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production. 2013 Feb 1
284 23187459 Nutlin-3, a small-molecule MDM2 inhibitor, sensitizes Caki cells to TRAIL-induced apoptosis through p53-mediated PUMA upregulation and ROS-mediated DR5 upregulation. 2013 Mar 2
285 23216904 ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence. 2013 Jan 1
286 23274516 p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. 2013 Feb 15 2
287 23314357 ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53. 2013 Mar 2
288 23376438 Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages. 2013 Apr 3
289 23469783 [Effect and mechanism of iron-catalyzed oxidative stress on mesenchymal stem cells]. 2013 Feb 1
290 23492768 Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. 2013 Mar 14 1
291 23533526 Subamolide a induces mitotic catastrophe accompanied by apoptosis in human lung cancer cells. 2013 1
292 23665932 Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells. 2013 1
293 23680455 Antioxidants: friends or foe in prevention or treatment of cancer: the debate of the century. 2013 Aug 15 1
294 23684722 Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells. 2013 Jul 9 2
295 23703322 p53 regulates a non-apoptotic death induced by ROS. 2013 Nov 2
296 23768371 Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells. 2013 Nov 1 2
297 23786650 Alpha particle-induced bystander effect is mediated by ROS via a p53-dependent SCO2 pathway in hepatoma cells. 2013 Dec 1
298 23807740 Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. 2013 Oct 3
299 23817040 Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells. 2013 Jul 26 2
300 23841076 The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. 2013 3