Diazoxide

insulin ; Homo sapiens







109 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 34046157 The danger of diazoxide in the neonatal intensive care unit. 2021 1
2 32274651 The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD. 2020 Aug 1
3 34055813 Persistent Hypoglycemia with Polycystic Kidneys: A Rare Combination - A Case Report. 2020 Sep-Dec 1
4 31218401 Genotype and phenotype analysis of a cohort of patients with congenital hyperinsulinism based on DOPA-PET CT scanning. 2019 Aug 1
5 29618011 Effects of Diazoxide-Mediated Insulin Suppression on Glucose and Lipid Metabolism in Nondiabetic Obese Men. 2018 Jun 1 4
6 28115493 Esculentin-2CHa(1-30) and its analogues: stability and mechanisms of insulinotropic action. 2017 Mar 1
7 28400489 Diazoxide for Lowering Insulin Levels in Breast Cancer Patients. 2017 Apr 1
8 28507564 Management of the hormonal syndrome of neuroendocrine tumors. 2017 Apr 1 1
9 26878387 Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer. 2016 Feb 15 3
10 27603903 Diazoxide in Children With Obesity After Hypothalamic-Pituitary Lesions: A Randomized, Placebo-Controlled Trial. 2016 Dec 1
11 26116696 Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro. 2015 Oct 1
12 26137438 A major role of insulin in promoting obesity-associated adipose tissue inflammation. 2015 Jul 2
13 26392140 Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth. 2015 Dec 1
14 23303986 A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. 2012 1
15 21378174 Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia. 2011 Apr 2
16 20028939 Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control. 2010 Mar 2
17 19218500 Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid. 2009 Apr 2
18 19623043 Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness. 2009 Sep 1
19 18476985 Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression. 2008 Dec 4
20 17289040 Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome. 2007 Jul 1
21 17360975 Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator. 2007 Jun 1
22 17559844 Role of insulin in the hyperandrogenemia of lean women with polycystic ovary syndrome and normal insulin sensitivity. 2007 Oct 1
23 17587399 No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. 2007 Jul 4
24 16475928 Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives. 2006 1
25 16527842 Diphenylhydantoin suppresses glucose-induced insulin release by decreasing cytoplasmic H+ concentration in pancreatic islets. 2006 Jun 1
26 17296510 Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences. 2006 Dec 1
27 15339745 Mechanism, temporal patterns, and magnitudes of the metabolic responses to the KATP channel agonist diazoxide. 2005 Jan 3
28 15734853 Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. 2005 Mar 1
29 15811140 Diazoxide-mediated insulin suppression in obese men: a dose-response study. 2005 May 10
30 16356235 Bench-to-bedside review: Antidotal treatment of sulfonylurea-induced hypoglycaemia with octreotide. 2005 1
31 14706058 Nine weeks of bedtime diazoxide is well tolerated and improves beta-cell function in subjects with Type 2 diabetes. 2004 Jan 2
32 15220194 Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. 2004 Jul 1
33 15333483 Temporary preservation of beta-cell function by diazoxide treatment in childhood type 1 diabetes. 2004 Sep 2
34 12865318 Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets. 2003 Aug 5
35 12958175 ATP-sensitive potassium channels induced in liver cells after transfection with insulin cDNA and the GLUT 2 transporter regulate glucose-stimulated insulin secretion. 2003 Sep 2
36 14660022 Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. 2003 Dec 15 1
37 11815454 Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon. 2002 Feb 1
38 12213059 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells. 2002 Sep 12 1
39 12414839 BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism. 2002 Nov 1
40 12522324 Improved beta cell function after short-term treatment with diazoxide in obese subjects with type 2 diabetes. 2002 Dec 1
41 11249067 Characterization of secretory and morphologic properties of primary cultured endocrine cells from porcine pancreata. 2001 Mar 1
42 11078450 Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation. 2000 Nov 1
43 10050013 Influence of nitric oxide modulators on cholinergically stimulated hormone release from mouse islets. 1999 Mar 1 1
44 9473513 Necessity of endogenous GTP derived from glucose-6-phosphate for insulin secretion augmented by glucose under protein kinase A activation. 1998 Feb 4 1
45 9540027 Induction of beta-cell rest in type 1 diabetes. Studies on the effects of octreotide and diazoxide. 1998 Mar 1
46 9626118 Beneficial effect of diazoxide in obese hyperinsulinemic adults. 1998 Jun 2
47 9653515 The nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester potentiates insulin secretion stimulated by glucose and L-arginine independently of its action on ATP-sensitive K+ channels. 1998 Feb 2
48 9724074 Leptin levels in women with polycystic ovary syndrome before and after treatment with diazoxide. 1998 Aug 3
49 9727845 Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria. 1998 Aug 1
50 9877233 Evidence for nitric oxide mediated effects on islet hormone secretory phospholipase C signal transduction mechanisms. 1998 Aug 1