| 1 |
31342643 | SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors. | 2020 Jan |
1 |
| 2 |
31091439 | PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. | 2019 May 14 |
1 |
| 3 |
26683831 | PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a. | 2016 Feb 1 |
1 |
| 4 |
25721445 | Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. | 2015 |
1 |
| 5 |
26453165 | Polymeric carrier-mediated intracellular delivery of phosphatidylinositol-3,4,5-trisphosphate to overcome insulin resistance. | 2015 |
2 |
| 6 |
23640896 | Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. | 2013 Jun 14 |
1 |
| 7 |
22751929 | Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1. | 2012 Sep |
1 |
| 8 |
19082482 | SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway, CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells. | 2009 Jan |
1 |
| 9 |
19297450 | Inhibition of insulin-stimulated hydrogen peroxide production prevents stimulation of sodium transport in A6 cell monolayers. | 2009 Jun |
1 |
| 10 |
19357636 | Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. | 2009 |
2 |
| 11 |
18288188 | Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. | 2008 Feb 21 |
2 |
| 12 |
18303120 | Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation. | 2008 May |
4 |
| 13 |
18492765 | Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3. | 2008 Sep |
1 |
| 14 |
17115034 | Forward chemical genetic approach identifies new role for GAPDH in insulin signaling. | 2007 Jan |
1 |
| 15 |
16672266 | Thin layer chromatography-blotting, a novel method for the detection of phosphoinositides. | 2006 Apr |
2 |
| 16 |
15537704 | The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway. | 2005 Jan |
1 |
| 17 |
15576463 | Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. | 2005 Mar |
1 |
| 18 |
15653324 | Restraining PI3K: mTOR signalling goes back to the membrane. | 2005 Jan |
1 |
| 19 |
15919791 | Phosphatidylinositol 4,5-bisphosphate reverses endothelin-1-induced insulin resistance via an actin-dependent mechanism. | 2005 Jun |
1 |
| 20 |
14645219 | Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. | 2004 Feb 20 |
1 |
| 21 |
15100098 | Phosphatidylinositol 3,4,5-trisphosphate: an early mediator of insulin-stimulated sodium transport in A6 cells. | 2004 Aug |
1 |
| 22 |
15209375 | PDK1, the master regulator of AGC kinase signal transduction. | 2004 Apr |
2 |
| 23 |
15282193 | Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na(+) channels. | 2004 Dec |
1 |
| 24 |
12582202 | Single cell imaging of PI3K activity and glucose transporter insertion into the plasma membrane by dual color evanescent wave microscopy. | 2003 Feb 11 |
1 |
| 25 |
12808101 | Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells. | 2003 Jul |
1 |
| 26 |
12912916 | Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. | 2003 Aug 15 |
1 |
| 27 |
14560023 | Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. | 2003 Nov |
1 |
| 28 |
11802782 | Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. | 2002 Feb 1 |
1 |
| 29 |
12147684 | Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes. | 2002 Oct 11 |
1 |
| 30 |
11270682 | Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus. | 2001 Feb |
2 |
| 31 |
11513726 | Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity. | 2001 Sep 1 |
1 |
| 32 |
10777587 | The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes. | 2000 Apr 28 |
1 |
| 33 |
10928124 | Accelerated decline of blood glucose after intravenous glucose injection in a patient with Cowden disease having a heterozygous germline mutation of the PTEN/MMAC1 gene. | 2000 May-Jun |
1 |
| 34 |
10567235 | Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes. | 1999 Dec 1 |
2 |
| 35 |
9585135 | Activation of PI 3-kinase by G protein betagamma subunits. | 1998 |
2 |
| 36 |
9593664 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | 1998 May 29 |
1 |
| 37 |
9832437 | Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis. | 1998 Dec |
1 |
| 38 |
9247112 | PDK1, one of the missing links in insulin signal transduction? | 1997 Jun 23 |
1 |
| 39 |
8645147 | Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. | 1996 May 1 |
1 |
| 40 |
8713057 | Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells. | 1996 Jul 15 |
4 |
| 41 |
8713074 | Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and beta gamma-subunits of GTP-binding proteins. | 1996 Jul 15 |
2 |
| 42 |
8761472 | Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport. | 1996 Aug 15 |
3 |
| 43 |
8769317 | Insulin and ATP stimulate actin polymerization in U937 cells by a wortmannin-sensitive mechanism. | 1996 Aug 19 |
1 |
| 44 |
7836438 | The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport. | 1995 Feb 3 |
1 |
| 45 |
7887929 | Identification of phosphatidylinositol 3,4,5-trisphosphate in pancreatic islets and insulin-secreting beta-cells. | 1995 Mar 8 |
2 |