Threonine

insulin ; Homo sapiens







198 Article(s)
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101 11818508 The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. 2002 Feb 1
102 11884412 Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. 2002 May 17 1
103 11948686 Role of mTOR in the degradation of IRS-1: regulation of PP2A activity. 2002 1
104 12018409 Isosteric replacement of A3 Val of porcine insulin by allo-Thr. 2002 Jan 5
105 12033942 Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation. 2002 Jun 4 3
106 12051762 Rapamycin partially prevents insulin resistance induced by chronic insulin treatment. 2002 May 10 1
107 12153745 The (ProB27, ThrB28) human insulin analogue is more potent and more rapidly absorbed from subcutis than human insulin. 2002 Aug 1
108 12189904 Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease. 2002 Apr 2
109 12351701 Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors. 2002 Oct 1
110 11147790 Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation. 2001 Jan 1
111 11160134 Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. 2001 Jan 1
112 11237210 Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. 2001 3
113 11368419 Insulin-sensitive phospholipid signaling systems and glucose transport. Update II. 2001 Apr 1
114 11374539 Analysis of the signal pathways involved in the regulation of fatty acid synthase gene expression by insulin and somatotropin. 2001 May 1
115 11438661 Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. 2001 Aug 1
116 11498541 Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. 2001 Oct 12 1
117 11517220 Activities of monomeric insulin analogs at position A8 are uncorrelated with their thermodynamic stabilities. 2001 Oct 26 1
118 11524020 Flexibility and bioactivity of insulin: an NMR investigation of the solution structure and folding of an unusually flexible human insulin mutant with increased biological activity. 2001 Sep 4 4
119 11679435 Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. 2001 Nov 1
120 11733864 Role of three FKHR phosphorylation sites in insulin inhibition of FKHR action in hepatocytes. 2001 Nov 2
121 11795838 Albert Renold memorial lecture: molecular background of nutritionally induced insulin resistance leading to type 2 diabetes--from animal models to humans. 2001 2
122 11895080 Mutational analysis of the three conserved valine residues of insulin and a proposal of "isosteric residue". 2001 Dec 1
123 11915930 Mechanisms of muscle insulin resistance in obese individuals. 2001 Dec 2
124 10694991 Physiologic and molecular alterations in carbohydrate metabolism during pregnancy and gestational diabetes mellitus. 2000 Mar 1
125 10781824 Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner. 2000 Apr 21 1
126 10830273 Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes. 2000 Jun 2
127 10847581 A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. 2000 Jun 2
128 10871198 Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnancy and GDM. 2000 Apr 2
129 10923637 Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. 2000 Aug 3
130 11030562 Yeast secretory expression of insulin precursors. 2000 Sep 1
131 11080610 Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply. 2000 Oct 1
132 10327603 Purification and characterization of insulin and peptides derived from proglucagon and prosomatostatin from the fruit-eating fish, the pacu Piaractus mesopotamicus. 1999 Jan 1
133 10497255 Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function. 1999 Oct 1 2
134 10567013 Threonine phosphorylations induced by RX-871024 and insulin secretagogues in betaTC6-F7 cells. 1999 Nov 1
135 9493129 Protein phosphatase 2B-dependent pathway of insulin action on single Cl- channel conductance in renal epithelium. 1998 Feb 1 1
136 9632736 Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. 1998 Jun 26 2
137 9681494 Purification and characterization of insulin, glucagon, and two glucagon-like peptides with insulin-releasing activity from the pancreas of the toad, Bufo marinus. 1998 Aug 3
138 9763533 Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene. 1998 Oct 2
139 9801458 Freeze tolerance in the wood frog Rana sylvatica is associated with unusual structural features in insulin but not in glucagon. 1998 Oct 1
140 9920385 Hydrophilic Thr can replace the hydrophobic and absolutely conservative A3Val in insulin. 1998 Dec 8 1
141 10212843 Cellular mechanism of nutritionally induced insulin resistance: the desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome. 1998 1
142 10684091 [A study of immobilized enzyme-assisted semisynthesis of human insulin]. 1998 Sep 2
143 9253345 Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects. 1997 Aug 1
144 8626428 SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways. 1996 Mar 15 1
145 8626671 Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. 1996 May 10 1
146 8813726 Structure and expression of the insulin-like peptide receptor from amphioxus. 1996 Jul 1
147 8876979 Studies on receptor binding site of insulin: the hydrophobic B12Val can be substituted by hydrophilic thr. 1996 Aug 1
148 8916921 Purification and characterization of an insulin-stimulated insulin receptor serine kinase. 1996 Nov 12 1
149 7615833 Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered. 1995 Jul 2
150 7657664 Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. 1995 Sep 1 1