Flucytosine

cytosine deaminase ; Saccharomyces cerevisiae S288C







20 Article(s)
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1 28034675 CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii. 2017 Mar 1
2 28387831 Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity. 2017 Jul 1 1
3 26223587 Absence of a gene encoding cytosine deaminase in the genome of the agaricomycete Coprinopsis cinerea enables simple marker recycling through 5-fluorocytosine counterselection. 2015 Aug 1
4 22076044 Oncolytic herpes simplex virus expressing yeast cytosine deaminase: relationship between viral replication, transgene expression, prodrug bioactivation. 2012 Mar 2
5 22208667 Role of glutamate 64 in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase. 2012 Jan 10 3
6 22426744 Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties. 2012 Jun 4
7 22547150 Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression. 2012 Sep 2
8 22892453 Targeted tumor therapy with a fusion protein of an antiangiogenic human recombinant scFv and yeast cytosine deaminase. 2012 Sep 1
9 18291415 Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine. 2008 Mar 28 3
10 18783590 Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from yeast. 2008 Sep 10 2
11 17394949 Cytosine deaminase/5-fluorocytosine exposure induces bystander and radiosensitization effects in hypoxic glioblastoma cells in vitro. 2007 Apr 1 2
12 17545615 Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model. 2007 Jun 1 2
13 16845689 Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. 2006 Jul 15 1
14 15823054 Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase. 2005 Apr 19 1
15 16088873 Cytosine deaminase MX cassettes as positive/negative selectable markers in Saccharomyces cerevisiae. 2005 Jul 30 2
16 15509509 The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies. 2004 Nov 2
17 12566311 Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model. 2003 Feb 1 1
18 12777821 Crystallization and preliminary crystallographic analysis of yeast cytosine deaminase. 2003 May 1
19 11454690 Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil. 2001 Jul 15 2
20 9000374 Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans. 1997 Jan 3