ellipticine

cytochrome P450 family 1 subfamily A member 1 ; Homo sapiens







13 Article(s)
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1 29471073 The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. 2018 Apr 1 3
2 22167207 Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. 2011 2
3 20027146 Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells. 2009 1
4 17656468 The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism. 2007 Oct 2
5 16507648 Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients. 2006 May 1
6 17159771 Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes. 2006 Dec 1
7 15548707 The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide. 2004 Nov 15 1
8 12123750 Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes. 2002 Jul 15 1
9 11218050 Formation of DNA adducts from oil-derived products analyzed by 32P-HPLC. 2001 Jan 1
10 11790342 Catalytic properties of CYP1A isoforms in the liver of an agnathan (Lampetra fluviatilis) and two species of teleost (Pleuronectes flesus, Anguilla anguilla). 2000 Feb 1
11 10490621 An autoregulatory loop controlling CYP1A1 gene expression: role of H(2)O(2) and NFI. 1999 Oct 1
12 8759031 Atypical cytochrome P450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level. Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism. 1996 Aug 23 2
13 8474022 Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. 1993 Apr 1