alpha-naphthoflavone

cytochrome P450 family 1 subfamily A member 1 ; Homo sapiens







60 Article(s)
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1 34474468 Perspective of structural flexibility on selective inhibition towards CYP1B1 over CYP1A1 by α-naphthoflavone analogs. 2021 Sep 22 3
2 32060993 Inhibition of human CYP1 enzymes by a classical inhibitor α-naphthoflavone and a novel inhibitor N-(3, 5-dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study. 2020 May 5
3 30971064 Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes. 2019 Apr 11 2
4 31203411 Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells. 2019 Jul 2
5 28834568 Methylated polycyclic aromatic hydrocarbons and/or their metabolites are important contributors to the overall estrogenic activity of polycyclic aromatic hydrocarbon-contaminated soils. 2018 Feb 1
6 29332599 The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells. 2018 2
7 30010034 Transplacental transfer and metabolism of diuron in human placenta. 2018 Oct 1 2
8 28103884 Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation. 2017 Jan 19 1
9 27113703 The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity. 2016 Jun 24 1
10 22749133 The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation. 2013 Feb 1
11 23033491 Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. 2013 Jan 2
12 23452206 Cigarette smoke condensate extracts induce IL-1-beta production from rheumatoid arthritis patient-derived synoviocytes, but not osteoarthritis patient-derived synoviocytes, through aryl hydrocarbon receptor-dependent NF-kappa-B activation and novel NF-kappa-B sites. 2013 Jun 1
13 23508959 Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. 2013 May 3 1
14 22837390 Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages. 2012 Nov 1
15 21127131 Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. 2011 Mar 1
16 21244437 Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes. 2011 Oct 1
17 21726170 In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450. 2011 Nov 1
18 20187624 3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively. 2010 Mar 15 1
19 20435083 Cytochromes P4501 (CYP1): catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo. 2010 Jun 29 1
20 20550209 Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor. 2010 Jul 14 2
21 21162728 Diesel exhaust particles induce CYP1A1 and pro-inflammatory responses via differential pathways in human bronchial epithelial cells. 2010 Dec 16 1
22 19386251 Effect of PCB153 on BaP-induced genotoxicity in HepG2 cells via modulation of metabolic enzymes. 2009 Apr 30 2
23 19553035 PCB126 enhanced the genotoxicity of BaP in HepG2 cells by modulating metabolic enzyme and DNA repair activities. 2009 Sep 10 2
24 19789301 UVR exposure sensitizes keratinocytes to DNA adduct formation. 2009 Oct 1
25 18059023 Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells. 2008 Apr 1 2
26 18065768 Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells. 2008 Mar 1 1
27 15766918 Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2. 2005 Feb 28 1
28 14962508 A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells. 2004 Feb 15 4
29 15081398 Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. 2004 May 7 1
30 12495659 The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line. 2003 Jan 1
31 12023534 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. 2002 Jun 3
32 12127040 Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells. 2002 May 3
33 12147246 Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone. 2002 Aug 9 2
34 11768231 Aryl hydrocarbon receptor/dioxin receptor in human monocytes and macrophages. 2001 Oct 1
35 10875683 Identification of cytochrome P450 isoform involved in the metabolism of YM992, a novel selective serotonin re-uptake inhibitor, in human liver microsomes. 2000 May 1
36 10964100 Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue. 2000 Sep 1
37 11082432 Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytes. 2000 Dec 1
38 9890552 Cytochrome 1A1 induction by primaquine in human hepatocytes and HepG2 cells: absence of binding to the aryl hydrocarbon receptor. 1999 Feb 1 1
39 10473105 Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1. 1999 Aug 1
40 10534316 Catalysis of drug oxidation during embryogenesis in human hepatic tissues using imipramine as a model substrate. 1999 Nov 1
41 9418899 Constitutive activation of the aromatic hydrocarbon receptor. 1998 Jan 1
42 9774143 Decreased expression of gamma-glutamyltranspeptidase in the intestinal cell line Caco-2 by inducers of cytochrome P450 1A1. 1998 Oct 1 1
43 9089421 Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors. 1997 Mar 1
44 9093392 Mutagenicity of the atmospheric transformation products 2-nitrofluoranthene and 2-nitrodibenzopyranone in Salmonella and human cell forward mutation assays. 1997 Mar 17 2
45 9105404 Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole. 1997 Feb 21 1
46 9169082 Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor. 1997 May 1
47 9223567 Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. 1997 Jul 1
48 8759031 Atypical cytochrome P450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level. Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism. 1996 Aug 23 2
49 8818577 Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. 1996 Jul 1
50 7554063 p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. 1995 Sep 1