Polycyclic Aromatic Hydrocarbons

cytochrome P450 family 1 subfamily A member 1 ; Homo sapiens







213 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
51 20961953 In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. 2011 Jan 1
52 21081473 Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. 2011 Feb 1
53 21376804 CYP1A1/1B1 and CYP2A6/2A13 activity is conserved in cultures of differentiated primary human tracheobronchial epithelial cells. 2011 Jun 1
54 21402622 The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies. 2011 May 2
55 21646728 Human cytochrome P450 1A1 is a novel target gene of liver X receptor α. 2011 3
56 21669939 The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. 2011 Sep 3
57 21787681 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentration in Thai bus drivers. 2011 Jan 1
58 21882217 A case-control study of asphalt and tar exposure and lung cancer in minorities. 2011 Nov 2
59 22096847 [Association between polymorphisms of metabolic genes and telomere length in workers exposed to polycyclic aromatic hydrocarbon]. 2011 Jun 1
60 24323584 Association of CYP1A1 Gene Polymorphism with Ischemic Stroke in South Indian Population. 2011 Mar 1
61 19365803 Differential action of chlorinated polycyclic aromatic hydrocarbons on aryl hydrocarbon receptor-mediated signaling in breast cancer cells. 2010 Apr 1
62 19608585 Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. 2010 Jan 2
63 20080079 Neurogenic-committed human pre-adipocytes express CYP1A isoforms. 2010 Mar 30 2
64 20542099 Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells. 2010 Sep 1 2
65 20596254 CYP1A1 gene polymorphisms as a risk factor for pterygium. 2010 Jun 9 4
66 20700368 An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium. 2010 Apr 8 2
67 18952161 Air pollution particulate matter (PM2.5)-induced gene expression of volatile organic compound and/or polycyclic aromatic hydrocarbon-metabolizing enzymes in an in vitro coculture lung model. 2009 Feb 1
68 19202560 Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. 2009 Jan-Feb 2
69 19346634 Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. 2009 Jan 2
70 19362136 The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells. 2009 Aug 5
71 19526463 Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: the role of heme oxygenase-1. 2009 May-Jun 5
72 19538838 [Relationship between CYP1A1 gene polymorphisms and urinary 1-hydroxypyrene levels in coke oven workers]. 2009 May 1
73 19786002 Association of CYP1A1*2A polymorphism with male infertility in Indian population. 2009 Dec 4
74 19789301 UVR exposure sensitizes keratinocytes to DNA adduct formation. 2009 Oct 1
75 17651397 Polymorphisms in CYP1A1 gene are associated with male infertility in a Chinese population. 2008 Sep 4
76 17874067 Induction of CYP1A1 in rat liver after ingestion of mussels contaminated by Erika fuel oils. 2008 Feb 1
77 17919675 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. 2008 Feb 1 6
78 18178302 Gene expression induction of volatile organic compound and/or polycyclic aromatic hydrocarbon-metabolizing enzymes in isolated human alveolar macrophages in response to airborne particulate matter (PM2.5). 2008 Feb 28 1
79 18494146 Changes in gene expression induced by polycyclic aromatic hydrocarbons in the human cell lines HepG2 and A549. 2008 Mar 1
80 18797853 Analysis of CYP1A1 induction in single cells of urothelial cell populations by flow cytometry. 2008 Nov 2
81 19138996 Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation. 2008 Nov 3
82 19317600 Polymorphism of CYP1A1*2C, GSTM1*0, and GSTT1*0 in a Mexican Mestizo population: a similitude analysis. 2008 Aug 2
83 17060372 Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1. 2007 Jan 2
84 17187366 Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar. 2007 Mar 15 1
85 17431034 CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies. 2007 Jul 3
86 17440990 Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers. 2007 May 1
87 17462623 Ambient particulate matter (PM2.5): physicochemical characterization and metabolic activation of the organic fraction in human lung epithelial cells (A549). 2007 Oct 1
88 17560011 Leukemogenic AML1-ETO fusion protein increases carcinogen-DNA adduct formation with upregulated expression of cytochrome P450-1A1 gene. 2007 Aug 1
89 17560072 Developing a high-throughput system for the screening of cytochrome P450 1A1--inhibitory polyphenols. 2007 Sep 1
90 17630984 An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites. 2007 Aug 1
91 17707923 HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation. 2007 Sep-Oct 1
92 17884947 Cellular defense mechanisms against benzo[a]pyrene in testicular Leydig cells: implications of p53, aryl-hydrocarbon receptor, and cytochrome P450 1A1 status. 2007 Dec 1
93 17981384 Differential effect of over-expressing UGT1A1 and CYP1A1 on xenobiotic assault in MCF-7 cells. 2007 Dec 5 1
94 16416283 Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects. 2006 May 2
95 16472762 CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. 2006 Mar 31 1
96 16485905 Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. 2006 Feb 1
97 16581943 Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone. 2006 Jul 1
98 16611024 Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. 2006 Apr 1
99 17017525 Unique cytochromes P450 in human brain: implication in disease pathogenesis. 2006 1
100 17158763 Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants. 2006 Dec 2