Polycyclic Aromatic Hydrocarbons

cytochrome P450 family 1 subfamily A member 1 ; Homo sapiens







213 Article(s)
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1 34929281 Epidemiologic evidence of exposure to polycyclic aromatic hydrocarbons and breast cancer: A systematic review and meta-analysis. 2022 Mar 1
2 35180652 Polymorphisms in PAH metabolising enzyme CYP1A1 in colorectal cancer and their clinicopathological correlations. 2022 Mar 2
3 33023449 The Activation of Procarcinogens by CYP1A1/1B1 and Related Chemo-Preventive Agents: A Review. 2021 1
4 33319219 Cigarette smoking enhances the metabolic activation of the polycyclic aromatic hydrocarbon phenanthrene in humans. 2021 Apr 30 3
5 33333309 Identification of structural properties influencing the metabolism of polycyclic aromatic hydrocarbons by cytochrome P450 1A1. 2021 Mar 1 6
6 33559210 Comparing the effects of an exposure to a polycyclic aromatic hydrocarbon mixture versus individual polycyclic aromatic hydrocarbons during monocyte to macrophage differentiation: Mixture exposure results in altered immune metrics. 2021 Oct 1
7 34242741 Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer. 2021 Nov 7
8 31655123 Human CYP1A1 inhibition by flavonoids. 2020 Feb 2
9 32409577 Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. 2020 Jul 3 6
10 32730838 Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells. 2020 Oct 1 4
11 33283556 Particulate matter less than 10 μm (PM10) activates cancer related genes in lung epithelial cells. 2020 Nov - Dec 1
12 31051230 Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer. 2019 Jul 20 3
13 31358014 CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers. 2019 Jul 29 6
14 29458109 Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options. 2018 Jul 2
15 29471073 The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. 2018 Apr 1 2
16 29845565 Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons. 2018 Aug 1
17 30448188 Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. 2018 Dec 15 7
18 28365671 Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant. 2017 Mar 1 2
19 28384415 Downregulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines. 2017 Jun 2
20 28461126 Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes. 2017 Aug 1 2
21 28632937 Synthesis, biological evaluation and docking studies of trans-stilbene methylthio derivatives as cytochromes P450 family 1 inhibitors. 2017 Dec 2
22 28710019 Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines. 2017 Aug 15 1
23 25398514 Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. 2016 Feb 1
24 27243113 The Effect of the CYP1A1*2A Allele on Colorectal Cancer Susceptibility in a British Population. 2016 Aug 1
25 27285958 Cigarette smoking and hormones. 2016 Aug 1
26 27486223 Divergent Ah Receptor Ligand Selectivity during Hominin Evolution. 2016 Oct 1
27 27565807 Significant interactions between maternal PAH exposure and single nucleotide polymorphisms in candidate genes on B[ a ]P-DNA adducts in a cohort of non-smoking Polish mothers and newborns. 2016 Nov 1 2
28 27571070 Toxic Effects of the Major Components of Diesel Exhaust in Human Alveolar Basal Epithelial Cells (A549). 2016 Aug 26 2
29 27706624 Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis. 2016 Aug 26 1
30 25555259 Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs. 2015 Jan 2
31 26082767 Polycyclic aromatic hydrocarbons and cytochrome P450 in HIV pathogenesis. 2015 2
32 24588654 Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation. 2014 Apr 4
33 24761888 Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. 2014 3
34 24847427 Polymorphism of the cytochrome P-450 1A1 (A2455G) in women with breast cancer in Eastern Azerbaijan, Iran. 2014 Mar 2
35 25343551 CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population. 2014 Sep-Oct 1
36 21913209 Polycyclic aromatic hydrocarbons within airborne particulate matter (PM(2.5)) produced DNA bulky stable adducts in a human lung cell coculture model. 2013 Feb 1
37 22388733 Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen-dependent tumorigenesis of MCF-7 breast cancer cells. 2013 Jul 2
38 23111888 Cytochrome P4501A1 genotypes and smoking- and hypertension-related ischemic stroke risk. 2013 May 2
39 23475304 CYP1A1 MspI polymorphism is associated with prostate cancer susceptibility: evidence from a meta-analysis. 2013 May 2
40 23508959 Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. 2013 May 3 1
41 23733671 Profiling deleterious non-synonymous SNPs of smoker's gene CYP1A1. 2013 1
42 23816456 CYP1A1 genetic polymorphism and polycyclic aromatic hydrocarbons on pulmonary function in the elderly: haplotype-based approach for gene-environment interaction. 2013 Aug 29 1
43 23845848 Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR. 2013 Oct 24 2
44 24084344 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. 2013 Sep 1
45 21876539 Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. 2012 Nov 1
46 22198330 Environmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican children. 2012 Feb 18 2
47 22213191 DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung. 2012 Oct 1 2
48 22374940 Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis. 2012 Apr 4
49 22404339 Prooxidant and proinflammatory potency of air pollution particulate matter (PM₂.₅₋₀.₃) produced in rural, urban, or industrial surroundings in human bronchial epithelial cells (BEAS-2B). 2012 Apr 16 1
50 22945568 Exposure to polycyclic aromatic hydrocarbons: bulky DNA adducts and cellular responses. 2012 1