Benzo(a)pyrene

cytochrome P450 family 1 subfamily A member 1 ; Homo sapiens







191 Article(s)
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51 25805023 Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation. 2015 Jul 3
52 23994263 Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism. 2014 Oct 15 6
53 24532440 Role of the modulation of CYP1A1 expression and activity in chemoprevention. 2014 Jul 2
54 24588654 Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation. 2014 Apr 9
55 24664296 Curcumin and vitamin E protect against adverse effects of benzo[a]pyrene in lung epithelial cells. 2014 1
56 24736433 p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling. 2014 Jun 2
57 25199627 Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene. 2014 Nov 1
58 25245543 Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene. 2014 Nov 4
59 25638374 Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5. 2014 8
60 23036853 Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells. 2013 Jan 20 4
61 23508959 Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. 2013 May 3 1
62 23626760 Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes. 2013 2
63 23639521 Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation. 2013 Aug 15 1
64 24362093 Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study. 2013 1
65 21920623 ERα phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells. 2012 Mar 2
66 22374940 Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis. 2012 Apr 1
67 22470100 CYP1A1 is a target of miR-892a-mediated post-transcriptional repression. 2012 Jul 4
68 22581694 Alternation of extracellular matrix remodeling and apoptosis by activation of the aryl hydrocarbon receptor pathway in human periodontal ligament cells. 2012 Oct 1
69 22837390 Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages. 2012 Nov 2
70 23107701 Anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cells. 2012 Sep 15 1
71 25683418 Effects of quercetin metabolites on the enhancing effect of β-carotene on DNA damage and cytochrome P1A1/2 expression in benzo[a]pyrene-exposed A549 cells. 2012 Jul 15 1
72 20951464 Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells. 2011 Mar 1
73 21292640 Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin. 2011 May 4
74 21453744 T-2 toxin is a cytochrome P450 1A1 inducer and leads to MAPK/p38- but not aryl hydrocarbon receptor-dependent interleukin-8 secretion in the human intestinal epithelial cell line Caco-2. 2011 Jun 18 2
75 21507987 Detoxification: a novel function of BRCA1 in tumor suppression? 2011 Jul 2
76 21669939 The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. 2011 Sep 4
77 21720915 Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin. 2011 Oct 1
78 19879933 Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines. 2010 Feb 1 1
79 19896525 1,10-phenanthroline stabilizes mRNA of the carcinogen-metabolizing enzyme, cytochrome P450 1a1. 2010 Feb 1 2
80 19919601 Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. 2010 Jan 1
81 20163913 CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin. 2010 Jun 28 4
82 20307623 Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation. 2010 May 27 4
83 20371965 Malondialdehyde-modified low density lipoprotein (MDA-LDL)-induced cell growth was suppressed by polycyclic aromatic hydrocarbons (PAHs). 2010 Apr 2
84 20399842 The critical DNA damage by benzo(a)pyrene in lung tissues of smokers and approaches to preventing its formation. 2010 Sep 15 1
85 20435083 Cytochromes P4501 (CYP1): catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo. 2010 Jun 29 2
86 20542099 Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells. 2010 Sep 1 3
87 20553787 Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells. 2010 Jul-Aug 1
88 20654143 [Cytotoxicity and genomic damage of benzo[a]pyrene in gene transformed cell model]. 2010 Apr 2
89 19152381 Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells. 2009 Mar 2
90 19202560 Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. 2009 Jan-Feb 2
91 19406224 Global transcriptional characterization of a mouse pulmonary epithelial cell line for use in genetic toxicology. 2009 Aug 1
92 19553035 PCB126 enhanced the genotoxicity of BaP in HepG2 cells by modulating metabolic enzyme and DNA repair activities. 2009 Sep 10 3
93 19961161 1-Nitropyrene stabilizes the mRNA of cytochrome P450 1a1, a carcinogen-metabolizing enzyme, via the Akt pathway. 2009 Dec 3
94 17919675 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. 2008 Feb 1 2
95 18160334 Unexpected DNA damage caused by polycyclic aromatic hydrocarbons under standard laboratory conditions. 2008 Feb 29 1
96 18372000 Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. 2008 Jul 15 9
97 18569596 Miniaturization of primary porcine urinary bladder epithelial cell cultures and application for gene expression studies after exposure to benzo[a]pyrene. 2008 2
98 18569604 Evaluation of time dependence and interindividual differences in benzo[a]pyrene-mediated CYP1A1 induction and genotoxicity in porcine urinary bladder cell cultures. 2008 4
99 18793272 Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells. 2008 Nov 2
100 18797853 Analysis of CYP1A1 induction in single cells of urothelial cell populations by flow cytometry. 2008 Nov 1