| 1 |
34648192 | Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine. | 2022 Feb |
1 |
| 2 |
35483145 | In Silico simulation of Cytochrome P450-Mediated metabolism of aromatic amines: A case study of N-Hydroxylation. | 2022 Jun 1 |
1 |
| 3 |
34180113 | Enzymatic Tailoring in Luzopeptin Biosynthesis Involves Cytochrome P450-Mediated Carbon-Nitrogen Bond Desaturation for Hydrazone Formation. | 2021 Sep 1 |
2 |
| 4 |
32219694 | In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions. | 2020 Jun |
2 |
| 5 |
31151284 | Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors. | 2019 May 30 |
1 |
| 6 |
31605674 | Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation. | 2019 Dec |
2 |
| 7 |
30205091 | Methadone Metabolism and Drug-Drug Interactions: In Vitro and In Vivo Literature Review. | 2018 Dec |
2 |
| 8 |
25343291 | Enantioselective N-demethylation and hydroxylation of sibutramine in human liver microsomes and recombinant cytochrome p-450 isoforms. | 2014 |
1 |
| 9 |
21504003 | Characterization of cyanide-trapped methylated metabonates formed during reactive drug metabolite screening in vitro. | 2011 May 30 |
2 |
| 10 |
20081260 | Effect of diethyldithiocarbamate (DDC) and ticlopidine on CYP1A2 activity and caffeine metabolism: an in vitro comparative study with human cDNA-expressed CYP1A2 and liver microsomes. | 2009 Nov-Dec |
1 |
| 11 |
18098061 | Identification of cytochrome P450 enzymes responsible for N -dealkylation of a new oral erectogenic, mirodenafil. | 2008 Jan |
1 |
| 12 |
18311908 | Characterization of type II ligands in CYP2C9 and CYP3A4. | 2008 Mar 27 |
1 |
| 13 |
16802848 | Pharmacokinetic/pharmacodynamic profile of voriconazole. | 2006 |
2 |
| 14 |
16087391 | Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs. | 2005 Sep 5 |
2 |
| 15 |
16393888 | Metabolism and transport of oxazaphosphorines and the clinical implications. | 2005 |
3 |
| 16 |
14729370 | Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes. | 2004 Feb 14 |
1 |
| 17 |
15056479 | The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. | 2004 May |
1 |
| 18 |
15268978 | Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone. | 2004 Apr |
2 |
| 19 |
15801542 | Role of human cytochrome P450 3A4 in the metabolism of DA-8159, a new erectogenic. | 2004 Nov-Dec |
3 |
| 20 |
12564927 | Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis. | 2003 Feb 11 |
1 |
| 21 |
12893130 | Post-mortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood. | 2003 Jul 29 |
1 |
| 22 |
12936704 | Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes. | 2003 Aug |
3 |
| 23 |
12967198 | Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes. | 2003 Aug |
2 |
| 24 |
12206675 | Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding. | 2002 Sep 10 |
1 |
| 25 |
12214661 | Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase. | 2002 Aug |
2 |
| 26 |
12487729 | Comparison of rat and human cytochrome P450 (CYP) sources of N-alkylprotoporphyrin IX. Formation after interaction with porphyrinogenic xenobiotics: studies with cDNA-expressed single CYP enzymes. | 2002 Nov |
2 |
| 27 |
11298070 | Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil. | 2001 Mar |
1 |
| 28 |
11353758 | Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes. | 2001 Jun |
3 |
| 29 |
11504269 | Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations. | 2001 Aug |
2 |
| 30 |
11509577 | Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity. | 2001 Oct 26 |
1 |
| 31 |
11556812 | Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity. | 2001 Sep 15 |
1 |
| 32 |
11714275 | Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis. | 2001 Nov 27 |
1 |
| 33 |
10385214 | Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5. | 1999 Apr |
1 |
| 34 |
10424762 | Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate. | 1999 Aug 1 |
1 |
| 35 |
9600717 | Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. | 1998 Mar |
1 |
| 36 |
9635877 | Interindividual variation in the metabolic activation of heterocyclic amines and their N-hydroxy derivatives in primary cultures of human mammary epithelial cells. | 1998 May |
3 |
| 37 |
9248661 | Drug-mediated inactivation of cytochrome P450. | 1997 Jul |
1 |
| 38 |
8737124 | Pharmacokinetic interactions related to the chemical structures of fluoroquinolones. | 1996 May |
1 |
| 39 |
8854046 | Molecular modelling study of pyrrolidine-2,5-dione based aromatase inhibitors and other known inhibitors. | 1996 Mar |
1 |
| 40 |
7496999 | Different influences of two fractions of lung cytochrome b5 on reconstituted lung benzphetamine N-demethylase system. | 1995 Oct |
1 |
| 41 |
7640150 | Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. | 1995 Apr |
1 |
| 42 |
8847710 | Some aspects of the role of cytochrome P-450 isozymes in the N-oxidative transformation of secondary and tertiary amine compounds. | 1995 Oct |
2 |
| 43 |
7895609 | Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. | 1994 Nov-Dec |
1 |
| 44 |
7949373 | Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions. | 1994 Aug |
1 |
| 45 |
8082573 | Regulatory mechanisms in the activation of nitrogenous compounds by mammalian cytochrome P-450 isozymes. | 1994 |
2 |
| 46 |
1346997 | Characterization of the cytochrome P-450 gene family responsible for the N-dealkylation of the ergot alkaloid CQA 206-291 in humans. | 1992 Jan-Feb |
1 |
| 47 |
1519785 | Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. | 1992 Sep |
1 |
| 48 |
2618083 | Interactions of heterocyclic Maillard products with the hepatic microsomal monooxygenase system. | 1989 Nov |
1 |
| 49 |
2677363 | Terconazole. Pharmacology of a new antimycotic agent. | 1989 Aug |
1 |
| 50 |
2680407 | Induction of the alcohol-inducible form of cytochrome P-450 by nitrogen-containing heterocycles: effects on pyridine N-oxide production. | 1989 |
1 |