Acetaminophen

cytochrome P450 family 4 subfamily F member 3 ; Homo sapiens







30 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 35578608 Delayed Acetaminophen Absorption Resulting in Acute Liver Failure. 2022 1
2 30151903 Inhibition of CYP2E1 With Propylene Glycol Does Not Protect Against Hepatocellular Injury in Human Acetaminophen Daily-Dosing Model. 2019 Jan 8
3 31254976 A computational model for hepatotoxicity by coupling drug transport and acetaminophen metabolism equations. 2019 Sep 5
4 30121710 An insight into paracetamol and its metabolites using molecular docking and molecular dynamics simulation. 2018 Aug 18 3
5 28951593 MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. 2017 Sep 26 3
6 25658971 Density functional theory study on the formation of reactive benzoquinone imines by hydrogen abstraction. 2015 Mar 23 1
7 24949552 Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices. 2014 Sep 2 1
8 27147854 Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose? 2011 6
9 19219744 Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. 2009 Jan 3
10 18338302 Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. 2008 Mar 1
11 17497828 High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry. 2007 Jun 15 1
12 15078344 Characterization of the acetaminophen-induced degradation of cytochrome P450-3A4 and the proteolytic pathway. 2004 Apr 2
13 11866476 Reduction of toxic metabolite formation of acetaminophen. 2002 Mar 8 2
14 11377097 Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology. 2001 Jun 1
15 9152386 Catalysis of the cysteine conjugation and protein binding of acetaminophen by microsomes from a human lymphoblast line transfected with the cDNAs of various forms of human cytochrome P450. 1997 May 1
16 8877251 Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism. 1996 Sep 2
17 8470644 Acetaminophen hepatotoxicity: potentiation by isoniazid. 1993 Apr 2
18 1344831 [Omeprazole and liver functions]. 1992 Sep-Oct 1
19 1461639 [Alcohol and the liver: ethanol metabolism and the pathomechanism of alcoholic liver damage]. 1992 Dec 13 1
20 1546013 Recognizing acetaminophen hepatotoxicity in chronic alcoholics. 1992 Mar 1
21 2375760 Isolation of four forms of acetone-induced cytochrome P-450 in chicken liver by h.p.l.c. and their enzymic characterization. 1990 Jul 1 1
22 2519233 A theoretical study on the metabolic activation of paracetamol by cytochrome P-450: indications for a uniform oxidation mechanism. 1989 Jan-Feb 3
23 2703963 Biliary excretion of acetaminophen-glutathione as an index of toxic activation of acetaminophen: effect of chemicals that alter acetaminophen hepatotoxicity. 1989 Mar 1
24 3181604 The microsomal ethanol oxidizing system: its role in ethanol and xenobiotic metabolism. 1988 Jun 1
25 3342453 Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol. 1988 1
26 3385648 Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system. 1988 Jun 1
27 2868861 The mechanisms of cobalt chloride-induced protection against acetaminophen hepatotoxicity. 1986 Jan-Feb 2
28 3511825 Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. 1986 Mar 1
29 2983185 Metabolic activation and toxicity of acetaminophen and related analogs. A theoretical study. 1985 Mar 1
30 183224 Biochemical changes after hepatic injury from toxic doses of acetaminophen or furosemide. 1976 1