Pentostatin

adenosine deaminase ; Homo sapiens







116 Article(s)
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1 33948356 Cordycepin inhibits the proliferation of malignant peripheral nerve sheath tumor cells through the p53/Sp1/tubulin pathway. 2021 1
2 26659614 Mitochondrial Damage and Apoptosis Induced by Adenosine Deaminase Inhibition and Deoxyadenosine in Human Neuroblastoma Cell Lines. 2016 Jul 1
3 25447764 The combination of adenosine deaminase inhibition and deoxyadenosine induces apoptosis in a human astrocytoma cell line. 2015 Jan 1
4 22353632 Novel metabolic aspects related to adenosine deaminase inhibition in a human astrocytoma cell line. 2012 Apr 2
5 21463108 Mechanism of action of pentostatin and cladribine in hairy cell leukemia. 2011 Jun 2
6 19728741 Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. 2009 Oct 13 1
7 18602399 Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. 2008 Sep 12 1
8 18721115 Pentostatin in chronic lymphocytic leukemia. 2008 Sep 2
9 17097637 Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells. 2007 Jan 15 1
10 16549110 Pentostatin for the treatment of indolent lymphoproliferative disorders. 2006 Apr 3
11 15752710 Activation of deoxycytidine kinase by deoxyadenosine: implications in deoxyadenosine-mediated cytotoxicity. 2005 Apr 1 1
12 15837980 Pentostatin in steroid-refractory acute graft-versus-host disease. 2005 Apr 20 1
13 14630704 Regulation of adenosine receptor engagement by ecto-adenosine deaminase. 2004 Jan 2
14 14760072 CD26 expression correlates with a reduced sensitivity to 2'-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas. 2004 Jan 15 5
15 15135110 Determination of the deoxycytidine kinase activity in cell homogenates with a non-radiochemical assay using reversed-phase high performance liquid chromatography; Identification of a novel metabolite of 2-chlorodeoxyadenosine. 2004 Jun 15 1
16 12643924 Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors. 2003 Mar 24 1
17 12670468 Pentostatin in the treatment of hairy-cell leukemia. 2003 Mar 3
18 12150791 Interactions among adenosine deaminase, adenosine A(1) receptors and dopamine D(1) receptors in stably cotransfected fibroblast cells and neurons. 2002 2
19 11522446 Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells(1). 2001 Sep 1 2
20 10887640 CD26 in T-cell lymphomas: a potential clinical role? 2000 Jun 2
21 10926348 Clinical pharmacokinetics of nucleoside analogues: focus on haematological malignancies. 2000 Jul 1
22 11067867 Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures. 2000 Nov 1
23 10488704 Blunted anti-inflammatory response to adenosine in alcoholic cirrhosis. 1999 Sep 2
24 9495239 Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. 1998 Mar 2 1
25 9204061 Pentostatin (2'-deoxycoformycin) in the treatment of cutaneous T-cell lymphoma. 1997 Jun 1
26 9342431 Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial adenosine levels and infarct size. 1997 Aug 1
27 8846128 Successful treatment of two children with Langerhans' cell histiocytosis with 2'-deoxycoformycin. 1996 May 4
28 9010576 Purine analogs in chronic lymphocytic leukemia and Waldenström's macroglobulinemia. 1996 2
29 9022297 Metabolism of adenosine and deoxyadenosine by human erythrocytes and CCRF-CEM leukemia cells. 1996 Dec 3
30 14651224 Deoxycoformycin (pentostatin): clinical pharmacology, role in the chemotherapy of cancer, and use in other diseases. 1996 2
31 7733907 Mutagenesis of human adenosine deaminase to active forms that partially resist inhibition by pentostatin. 1995 Apr 17 7
32 8590388 Enhancement of the anti-HIV-1 activity of ddAdo by coformycin, EHNA and deaza-EHNA derivatives. 1995 Oct 1
33 11847552 Pentostatin (2prime prime or minute-Deoxycoformycin): Clinical Pharmacology, Role In Cancer Chemotherapy, and Future Prospects. 1995 Mar 2
34 7525186 Immunological and genetic abnormalities in chronic lymphocytic leukaemia. Impact of the purine analogues. 1994 1
35 7506651 Pentostatin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in lymphoproliferative disorders. 1993 Oct 1
36 8408919 Clinical significance of serum adenosine deaminase activity in patients with mycosis fungoides. 1993 Jul 1
37 1449110 Lack of significant activity of 2'-deoxycoformycin alone or in combination with adenine arabinoside in relapsed childhood acute lymphoblastic leukemia. A randomized phase II trial from the Childrens Cancer Study Group. 1992 Dec 2
38 1490883 Improved production of pentostatin and identification of fermentation cometabolites. 1992 Dec 1
39 1504093 Adenosine deaminase from Saccharomyces cerevisiae: kinetics and interaction with transition and ground state inhibitors. 1992 Aug 21 1
40 1504408 Pentostatin: an adenosine deaminase inhibitor for the treatment of hairy cell leukemia. 1992 Jul-Aug 2
41 1528066 Induction of apoptosis in CD4+ prolymphocytic leukemia by deoxyadenosine and 2'-deoxycoformycin. 1992 Aug 1
42 1730260 Genetic correction of cultured T cells from an adenosine deaminase-deficient patient: characteristics of non-transduced and transduced T cells. 1992 Jan 1
43 1679757 New purine analogues for the treatment of chronic B-cell malignancies. 1991 2
44 1715181 Inhibition of neutrophil superoxide production by adenosine released from vascular endothelial cells. 1991 Jul 2
45 1898656 Purine catabolism in polymorphonuclear neutrophils. Phorbol myristate acetate-induced accumulation of adenosine owing to inactivation of extracellularly released adenosine deaminase. 1991 Jan 2
46 1995064 Deoxyadenosine-resistant human T lymphoblasts with elevated 5'-nucleotidase activity. 1991 Jan 10 1
47 2033586 Escherichia coli mediated biosynthesis and in vitro anti-HIV activity of lipophilic 6-halo-2',3'-dideoxypurine nucleosides. 1991 May 1
48 2033591 Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs. 1991 May 1
49 2190792 Antineoplastic drugs in 1990. A review (Part I). 1990 Apr 1
50 2262486 Treatment of T-lineage acute lymphoblastic leukemia. 1990 Oct 1