pyrimidine

dihydroorotate dehydrogenase ; Mus musculus







21 Article(s)
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Pub. Year
#Total Relationships
1 35163469 Teriflunomide Preserves Neuronal Activity and Protects Mitochondria in Brain Slices Exposed to Oxidative Stress. 2022 Jan 28 1
2 32426367 Teriflunomide Does Not Change Dynamics of Nadph Oxidase Activation and Neuronal Dysfunction During Neuroinflammation. 2020 2
3 32850106 Teriflunomide preserves peripheral nerve mitochondria from oxidative stress-mediated alterations. 2020 1
4 30417265 Spatial and molecular changes of mouse brain metabolism in response to immunomodulatory treatment with teriflunomide as visualized by MALDI-MSI. 2019 Jan 2
5 28435533 Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. 2017 Apr 13 1
6 27391060 Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells. 2016 Aug 2 2
7 27597161 Discovery of a new structural class of competitive hDHODH inhibitors with in vitro and in vivo anti-inflammatory, immunosuppressive effects. 2016 Nov 15 1
8 23355744 Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation. 2013 Apr 2
9 23977077 Leflunomide reduces proliferation and induces apoptosis in neuroblastoma cells in vitro and in vivo. 2013 2
10 22692683 Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. 2012 Sep 15 4
11 20310011 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. 2010 Oct 2
12 18932012 Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitochondrial pathologies during aging. 2009 Aug 1
13 11248707 Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects? 2001 Mar 1
14 9353408 Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action. 1997 Nov 1
15 7673235 Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. 1995 Sep 22 1
16 2153375 Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer. 1990 Jan 1 2
17 2164443 In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients. 1990 Aug 1 1
18 2822596 Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390). 1987 1
19 3019518 Mechanism of action of the novel anticancer agent 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis. 1986 Oct 1
20 6249586 On the role of dihydroorotate dehydrogenase in growth cessation of Ehrlich ascites tumor cells cultured under oxygen deficiency. 1980 1
21 35542 Effect of 6-azauridine on de novo pyrimidine biosynthesis in cultured Ehrlich ascites cells. Orotate inhibition of dihydroorotase and dihydroorotate dehydrogenase. 1979 Jun 10 1