Folic Acid

thymidylate synthase ; Mus musculus







20 Article(s)
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1 33024270 Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer. 2021 Jan 2
2 22057276 Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA. 2011 Dec 23 2
3 11325838 Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. 2001 May 1 1
4 11534765 In vivo antitumor efficacy of CW252053, a folate-based thymidylate synthase inhibitor. 2001 Aug 1
5 21374032 5-Fluorouracil metabolizing enzymes. 1999 1
6 9154971 Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). 1997 May 9 1
7 8612303 AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. 1996 1
8 8911125 Modulation of [5-125I]iododeoxyuridine incorporation into tumour and normal tissue DNA by methotrexate and thymidylate synthase inhibitors. 1996 Aug 1
9 7702640 5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase. 1995 Mar 15 1
10 8521402 Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid. 1995 Dec 15 2
11 1516048 Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. 1992 Sep 15 1
12 2514611 A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase. 1989 Nov 1 1
13 2529254 Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells. 1989 Oct 15 2
14 2743307 Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo. 1989 Aug 1 1
15 3339615 Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin. 1988 Feb 1
16 3370638 Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells. 1988 Jun 15 1
17 2938731 Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies. 1986 Jun 2
18 2944577 Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. 1986 Oct 1
19 7108907 10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism. 1982 Jul 1
20 147465 Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate. 1978 Feb 1