Phosphatidylinositols

protein tyrosine kinase 2 beta ; Homo sapiens







37 Article(s)
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1 34811774 Structure and pro-inflammatory activities of bran polysaccharides from a novel wheat kernel. 2022 Jan 1
2 35412944 Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway. 2022 Apr 1
3 34739932 Investigation on the mechanisms of biochanin A alleviate PM10-induced acute pulmonary cell injury. 2021 Nov 2 1
4 31707337 Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways. 2020 Jan 1
5 31734375 Low-level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3K/Akt signaling pathway. 2020 May 1
6 31794514 Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion. 2020 Apr 1
7 31840737 Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway. 2020 Jan 31 1
8 31947601 Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing. 2020 Jan 14 1
9 31957818 MicroRNA-149 suppresses the malignant phenotypes of ovarian cancer via downregulation of MSI2 and inhibition of PI3K/AKT pathway. 2020 Jan 1
10 32057180 MEG3 is restored by schisandrin A and represses tumor growth in choriocarcinoma cells. 2020 Apr 1
11 32096172 MiR-19 enhances pancreatic cancer progression by targeting PTEN through PI3K/AKT signaling pathway. 2020 Feb 1
12 30735452 lncRNA GAS5 restrains CCl4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway. 2019 Apr 1 1
13 31553879 Preclinical Evaluation of a Fluorine-18 (18F)-Labeled Phosphatidylinositol 3-Kinase Inhibitor for Breast Cancer Imaging. 2019 Nov 4 1
14 31636720 Novel therapeutic avenues in triple-negative breast cancer: PI3K/AKT inhibition, androgen receptor blockade, and beyond. 2019 1
15 31684190 Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression. 2019 Nov 3 1
16 22121510 Understanding the relative affinity and specificity of the pleckstrin homology domain of protein kinase B for inositol phosphates. 2012 Jan 14 3
17 22553359 DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth. 2012 Aug 1
18 20138829 Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells. 2010 Apr 9 2
19 19149480 Targeted small-molecule inhibitors of protein kinase B as anticancer agents. 2009 Jan 1
20 19279164 Nuclear and mitochondrial signalling Akts in cardiomyocytes. 2009 May 1 1
21 18842113 The life of a cell: apoptosis regulation by the PI3K/PKB pathway. 2008 Nov 1 2
22 17203200 The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection. 2007 Feb 1
23 16619521 The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. 2006 Mar-Apr 2
24 15166230 Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake. 2004 Jul 30 1
25 14655756 Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. 2003 Oct 1
26 11435425 TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway. 2001 Aug 31 1
27 11477064 The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. 2001 Sep 21 1
28 11551924 Differential regulation of phosphoinositide metabolism by alphaVbeta3 and alphaVbeta5 integrins upon smooth muscle cell migration. 2001 Nov 9 1
29 11597931 Phosphatidylinositol 3-OH kinase-Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell line. 2001 Oct 1
30 11746362 Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress. 2001 Nov 1 1
31 10788440 Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. 2000 May 5 1
32 10797305 Thrombin-stimulated phosphatidylinositol 3-kinase activity in platelets is associated with activation of PYK2 tyrosine kinase: activation of both enzymes is aggregation independent. 2000 Jun 1
33 10983985 Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. 2000 Aug 1
34 10022914 Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. 1999 Mar 1
35 10102683 Activation of protein kinase B and induction of adipogenesis by insulin in 3T3-L1 preadipocytes: contribution of phosphoinositide-3,4,5-trisphosphate versus phosphoinositide-3,4-bisphosphate. 1999 Apr 1
36 10578066 Activation of protein kinase B induced by H(2)O(2) and heat shock through distinct mechanisms dependent and independent of phosphatidylinositol 3-kinase. 1999 Dec 2
37 9742206 Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. 1998 Oct 1 2