Serine

protein tyrosine kinase 2 beta ; Homo sapiens







81 Article(s)
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1 35124166 Protein Kinase B/Akt1 Phosphorylates Dysbindin-1A at Serine 10 to Regulate Neuronal Development. 2022 May 10 1
2 35330934 Akt: A Potential Drug Target for Metabolic Syndrome. 2022 2
3 35607451 Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway. 2022 1
4 33854635 SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling. 2021 1
5 32120136 Targeting AKT/PKB to improve treatment outcomes for solid tumors. 2020 Jan - Apr 2
6 32760285 PPARδ Attenuates Alcohol-Mediated Insulin Resistance by Enhancing Fatty Acid-Induced Mitochondrial Uncoupling and Antioxidant Defense in Skeletal Muscle. 2020 1
7 33633735 Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival. 2020 1
8 31134093 Review of Defective NADPH Oxidase Activity and Myeloperoxidase Release in Neutrophils From Patients With Cirrhosis. 2019 1
9 30013652 Juglone suppresses epithelial-mesenchymal transition in prostate cancer cells via the protein kinase B/glycogen synthase kinase-3β/Snail signaling pathway. 2018 Aug 1
10 26925779 Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization. 2016 Feb 1
11 27067543 Identification and characterization of an hnRNP E1 translational silencing motif. 2016 Jul 8 1
12 25882230 Fisetin Ameliorated Photodamage by Suppressing the Mitogen-Activated Protein Kinase/Matrix Metalloproteinase Pathway and Nuclear Factor-κB Pathways. 2015 May 13 1
13 25979114 Serine phosphorylation and arginine methylation at the crossroads to neurodegeneration. 2015 Sep 1
14 23690212 12-O-tetradecanoylphorbol-1,3-acetate-induced degradation of protein kinase B via ubiquitin-proteasomal pathway depends on its Ser473 phosphorylation in gastric cancer cells. 2013 1
15 22707636 TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism. 2012 Aug 1
16 23139742 Functional analyses of endometriosis-related polymorphisms in the estrogen synthesis and metabolism-related genes. 2012 1
17 21195757 Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center in hematopoietic cells. 2011 Apr 2
18 21592956 mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. 2011 Jul 15 3
19 20513353 Regulation of PIKfyve phosphorylation by insulin and osmotic stress. 2010 Jul 9 2
20 20515848 Important roles of Akt/PKB signaling in the aging process. 2010 Jun 1 2
21 20534540 Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase. 2010 Jun 22 1
22 19144640 DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif. 2009 Mar 6 1
23 19581418 Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1. 2009 Oct 1
24 19584241 Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. 2009 Jul 1
25 18160431 Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance. 2008 Mar 1
26 18557931 Infliximab inhibits DNA repair in ultraviolet B-irradiated premalignant keratinocytes. 2008 Nov 1
27 18667411 A portrait of tissue phosphoprotein stability in the clinical tissue procurement process. 2008 Oct 1
28 18687633 Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type. 2008 Oct 1
29 18718528 Serine 396 of PDK1 is required for maximal PKB activation. 2008 Nov 1
30 17336927 Synip phosphorylation is required for insulin-stimulated Glut4 translocation. 2007 Apr 27 1
31 16234845 Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats. 2006 Jul 2
32 16543730 DOCA-induced phosphorylation of glycogen synthase kinase 3beta. 2006 1
33 16836907 [Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC)-83 and SACC-LM cells]. 2006 Jun 4
34 17030608 BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites. 2006 Dec 1
35 16129678 The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal. 2005 Nov 11 2
36 16221682 mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. 2005 Dec 9 1
37 14668339 Androgen receptor mediates non-genomic activation of phosphatidylinositol 3-OH kinase in androgen-sensitive epithelial cells. 2004 Apr 9 1
38 14963038 Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation. 2004 Apr 23 1
39 15026413 Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease. 2004 May 28 1
40 15169778 Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. 2004 Aug 20 4
41 15538381 The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. 2004 Dec 8 1
42 12624792 Role of protein kinase B in Alzheimer's neurofibrillary pathology. 2003 Apr 2
43 14637150 Transforming growth factor-beta1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cells. 2003 Dec 12 5
44 11809746 Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes. 2002 May 17 1
45 11884412 Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. 2002 May 17 2
46 11897496 Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. 2002 Jun 1
47 12000750 Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. 2002 Aug 2 1
48 12107176 The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. 2002 Sep 13 1
49 12164932 Ganglioside loss promotes survival primarily by activating integrin-linked kinase/Akt without phosphoinositide 3-OH kinase signaling. 2002 Jul 3
50 12167717 Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. 2002 Sep 2