Imipramine

cytochrome P450 family 2 subfamily C member 19 ; Homo sapiens







20 Article(s)
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1 25719307 Pharmacogenetics of drug oxidation via cytochrome P450 (CYP) in the populations of Denmark, Faroe Islands and Greenland. 2015 Sep 1
2 24492587 Effect of cytochrome P450 2C19 and 2C9 amino acid residues 72 and 241 on metabolism of tricyclic antidepressant drugs. 2014 1
3 23486447 Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. 2013 May 1
4 28520379 Imipramine Therapy and CYP2D6 and CYP2C19 Genotype 2012 2
5 19884907 The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients. 2010 Jun 7
6 17667959 Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients. 2008 Jun 2
7 15199661 Some aspects of genetic polymorphism in the biotransformation of antidepressants. 2004 Jan-Feb 1
8 14640711 Chip-based P450 drug metabolism coupled to electrospray ionization-mass spectrometry detection. 2003 Dec 1 1
9 12065442 Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach. 2002 Jul 1
10 12228186 Inhibitory effects of tricyclic antidepressants (TCAs) on human cytochrome P450 enzymes in vitro: mechanism of drug interaction between TCAs and phenytoin. 2002 Oct 1
11 10886465 Pharmacogenetics and psychopharmacotherapy. 2000 Jun 1
12 10411572 A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. 1999 Aug 1
13 9923577 Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro. 1998 Nov-Dec 1
14 9084457 Imipramine demethylation in vivo: impact of CYP1A2, CYP2C19, and CYP3A4. 1997 Mar 2
15 9316174 Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy. 1997 Aug 5
16 8835703 Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients. 1996 Aug 4
17 8521680 Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19. 1995 Sep 1
18 8806399 Cytochrome P450 isozymes and antiepileptic drug interactions. 1995 1
19 8846618 Antidepressant drug interactions and the cytochrome P450 system. The role of cytochrome P450 2D6. 1995 1
20 8198931 The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation. 1994 Mar 2