Ticlopidine

cytochrome P450 family 2 subfamily C member 19 ; Homo sapiens







29 Article(s)
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1 28737446 Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims. 2018 Jul 1
2 27386066 "Influence of methadone on clopidogrel in addicts on methadone maintenance therapy" Drug interaction between methadone and clopidogrel. 2016 Spring 1
3 24855828 Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model. 2014 May 1
4 23474500 Comparative xenobiotic metabolism capacities and pesticide sensitivity in adults of Solea solea and Solea senegalensis. 2013 May 1
5 22652334 Assessment of drug-drug interactions caused by metabolism-dependent cytochrome P450 inhibition. 2012 Jun 25 2
6 21148250 Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics. 2011 Mar 1
7 21178986 Differential impacts of CYP2C19 gene polymorphisms on the antiplatelet effects of clopidogrel and ticlopidine. 2011 Feb 2
8 19948947 Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. 2010 Feb 1
9 19144769 Differential time- and NADPH-dependent inhibition of CYP2C19 by enantiomers of fluoxetine. 2009 Apr 1
10 19845434 Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel. 2009 Nov 4
11 18474675 Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes. 2008 Aug 1
12 19122335 Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine. 2008 1
13 17307149 3D structure modeling of cytochrome P450 2C19 and its implication for personalized drug design. 2007 Apr 6 1
14 17332142 Evaluation of 3-O-methylfluorescein as a selective fluorometric substrate for CYP2C19 in human liver microsomes. 2007 Jun 1
15 16272957 Interaction magnitude, pharmacokinetics and pharmacodynamics of ticlopidine in relation to CYP2C19 genotypic status. 2005 Dec 4
16 14563790 Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine. 2004 Jan 1
17 14977868 In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily. 2004 Mar 2
18 15056479 The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. 2004 May 1
19 15155554 Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro. 2004 Jun 1
20 12721102 Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. 2003 Apr 1
21 11181505 Metabolic characterization of the major human small intestinal cytochrome p450s. 2001 Mar 2
22 11580286 Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19. 2001 Oct 9 17
23 11764927 Inhibition by ticlopidine and its derivatives of human liver cytochrome p450. Mechanism-based inactivation of CYP 2C19 by ticlopidine. 2001 1
24 10759690 In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. 2000 Apr 3
25 10233213 Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism. 1999 Apr 6
26 10460802 The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6. 1999 Sep 1
27 10497136 Heterologous expression and kinetic characterization of human cytochromes P-450: validation of a pharmaceutical tool for drug metabolism research. 1999 Oct 1
28 10613611 Ticlopidine inhibits phenytoin clearance. 1999 Dec 1
29 9390115 Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. 1997 Nov 3