Phenobarbital

cytochrome P450 family 2 subfamily C member 19 ; Homo sapiens







18 Article(s)
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1 34730282 Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria. 2022 Jan 1
2 26496779 Clinical Pharmacology of Phenobarbital in Neonates: Effects, Metabolism and Pharmacokinetics. 2016 1
3 23551241 Phenobarbital-induced severe cutaneous adverse drug reactions are associated with CYP2C19*2 in Thai children. 2013 May 3
4 22331680 Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures. 2012 Jun 3
5 20509749 Expression and inducibility by phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22, and CYP3As in porcine liver, kidney, small intestine, and nasal tissues. 2010 Aug 1
6 27713373 Update on the Genetic Polymorphisms of Drug-Metabolizing Enzymes in Antiepileptic Drug Therapy. 2010 Aug 20 1
7 19702536 The transcriptional regulation of the human CYP2C genes. 2009 Jul 2
8 17375979 The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications. 2007 2
9 16789993 Effect of CYP2C19 genetic polymorphism on pharmacokinetics of phenytoin and phenobarbital in Japanese epileptic patients using Non-linear Mixed Effects Model approach. 2006 Jun 8
10 15557548 Pharmacogenetics and enzyme induction/inhibition properties of antiepileptic drugs. 2004 Nov 23 1
11 11854139 (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19. 2002 Mar 1
12 12130704 Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes. 2002 Aug 3
13 11181490 Induction of CYP2C genes in human hepatocytes in primary culture. 2001 Mar 1
14 11294510 P-hydroxylation of phenobarbital: relationship to (S)-mephenytoin hydroxylation (CYP2C19) polymorphism. 2001 Apr 2
15 10805060 CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics. 2000 Feb-Mar 4
16 9314612 Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. 1997 Sep 1
17 7554701 Effects of felbamate on the pharmacokinetics of phenobarbital. 1995 Sep 1
18 1306117 Induction of various cytochromes CYP2B, CYP2C and CYP3A by phenobarbitone in non-human primates. 1992 Aug 1