Etoposide

DNA topoisomerase II alpha ; Homo sapiens







29 Article(s)
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1 34550633 KMT2A-MAML2 rearrangement emerged and regressed during neuroblastoma therapy without leukemia after 12.8-year follow-up. 2022 Jan 2
2 35565244 Oral Etoposide and Trastuzumab Use for HER2-Positive Metastatic Breast Cancer: A Retrospective Study from the Institut Curie Hospitals. 2022 Apr 24 2
3 35596703 Functional characterization and clinical significance of super-enhancers in lung adenocarcinoma. 2022 May 21 1
4 35617303 Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIα intron-19 5' splice site: Generation of etoposide resistance in human leukemia K562 cells. 2022 8
5 33446509 CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5' Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells. 2021 Mar 3
6 33747282 Effect of TOP2A and ERCC1 gene polymorphisms on the efficacy and toxicity of cisplatin and etoposide-based chemotherapy in small cell lung cancer patients. 2021 2
7 33941661 A Role for VCP/p97 in the Processing of Drug-Stabilized TOP2-DNA Covalent Complexes. 2021 Jul 1
8 34031359 Pericentromeric Satellite III transcripts induce etoposide resistance. 2021 May 24 3
9 31836624 hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide. 2020 Mar 1
10 32193368 Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection. 2020 Mar 19 1
11 32414923 Topoisomerase IIα is essential for maintenance of mitotic chromosome structure. 2020 Jun 2 1
12 31271486 Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology. 2019 Oct 1
13 29514855 The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform. 2018 May 5
14 27974636 Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy. 2017 Jan 1
15 27974648 Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform. 2017 Jan 9
16 28110185 Computational analysis of Amsacrine resistance in human topoisomerase II alpha mutants (R487K and E571K) using homology modeling, docking and all-atom molecular dynamics simulation in explicit solvent. 2017 Mar 1
17 28611105 The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks. 2017 Oct 2
18 25605014 Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer. 2015 Feb 20 1
19 26421495 Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2α cleavage complexes in human cells. 2015 Nov 1
20 24327541 The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1. 2014 Feb 1
21 24336569 Genetic screens in human cells using the CRISPR-Cas9 system. 2014 Jan 3 1
22 23163762 Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor. 2013 Feb 1
23 24103454 MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. 2013 Oct 8 2
24 22285073 Expression analysis of TOP2A, MSH2 and MLH1 genes in MCF7 cells at different levels of etoposide resistance. 2012 Feb 4
25 22528119 The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II. 2012 Jul 3
26 22841979 The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. 2012 Dec 7 1
27 20824055 Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination. 2010 Sep 2 1
28 19003983 TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance. 2009 Feb 1 1
29 17089011 DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes. 2006 Dec 1