Simvastatin

apolipoprotein E ; Mus musculus







34 Article(s)
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1 35618653 A ROS-Responsive Simvastatin Nano-Prodrug and its Fibronectin-Targeted Co-Delivery System for Atherosclerosis Treatment. 2022 Jun 8 1
2 33864447 Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1. 2021 Apr 16 1
3 34349106 Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia. 2021 Aug 4 1
4 34422919 Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice. 2021 1
5 30713570 Yangyin Qingre Huoxue Method in Traditional Chinese Medicine Ameliorates Atherosclerosis in ApoE-/- Mice Suffering from High-Fat Diet and HSP65 Aggression. 2019 1
6 31731717 Lunasin Improves the LDL-C Lowering Efficacy of Simvastatin via Inhibiting PCSK9 Expression in Hepatocytes and ApoE-/- Mice. 2019 Nov 15 2
7 29735887 Ursolic Acid Attenuates Atherosclerosis in ApoE-/- Mice: Role of LOX-1 Mediated by ROS/NF-κB Pathway. 2018 May 7 1
8 27091343 Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase. 2016 Apr 18 1
9 26295063 Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation. 2015 Apr 2
10 24998652 [Effect of simvastatin on atherosclerosis and central aortic pressure in ApoE gene knockout mice]. 2014 May 2
11 23564080 Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE(-/-) mice by downregulating the HMGB1-RAGE axis. 2013 Jun 3
12 24080182 Simvastatin increases Prolyl-4-Hydroxylase α1 expression in atherosclerotic plaque and ox-LDL-stimulated human aortic smooth muscle cells via p38 MAPK and ERK1/2 signaling. 2013 Dec 1
13 22038096 Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p(53), Bcl-2 and Bcl-xL. 2012 Feb 2
14 22977450 Simvastatin and losartan differentially and synergistically inhibit atherosclerosis in apolipoprotein e(-/-) mice. 2012 Aug 1
15 23216643 Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in ApoE-deficient mice. 2012 Dec 5 2
16 21241519 Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet. 2011 Jan 18 3
17 19639539 Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy. 2010 Jan 1
18 20809215 Efficacy of simvastatin in reducing aortic dilatation in mouse models of abdominal aortic aneurysm. 2010 Dec 1
19 19729613 Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK. 2009 Nov 2
20 19738398 Effects of simvastatin on plasma lipoproteins and hearing loss in apolipoprotein E gene-deficient mice. 2009 1
21 18295249 Effect of simvastatin in apolipoprotein E deficient mice with surgically induced chronic renal failure. 2008 Apr 1
22 18443364 Diabetes reduces aortic endothelial gap junctions in ApoE-deficient mice: simvastatin exacerbates the reduction. 2008 Aug 1
23 19578502 Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice. 2008 Mar 12 1
24 17214935 [Effects of water extractives of a qi and blood regulating prescription on early atherosclerosis of apolipoprotein E-deficient mice]. 2007 Jan 1
25 16460674 Simvastatin causes the formation of cholesterol-rich remnants in mice lacking apoE. 2006 Mar 24 3
26 16920939 Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. 2006 Sep 1 3
27 15639308 Cardiovascular functional phenotypes and pharmacological responses in apolipoprotein E deficient mice. 2005 Mar 1
28 14752252 Effects of simvastatin on plasma lipoproteins and response to arterial injury in wild-type and apolipoprotein-E-deficient mice. 2004 Jan-Feb 2
29 15300198 Aortic eNOS expression and phosphorylation in Apo-E knockout mice: differing effects of rapamycin and simvastatin. 2004 Aug 1
30 15572054 Simvastatin enhances myocardial angiogenesis induced by vascular endothelial growth factor gene transfer. 2004 Dec 3
31 12818400 Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation. 2003 Apr 2
32 11947894 Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E. 2002 May 2
33 12426212 Simvastatin promotes atherosclerotic plaque stability in apoE-deficient mice independently of lipid lowering. 2002 Nov 1 2
34 11382730 Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice. 2001 May 29 3