2 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
| 1 | 12416030 | Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells. | 2002 Sep-Oct | 1 |
| 2 | 11241661 | The rate of folate receptor alpha (FR alpha) synthesis in folate depleted CHL cells is regulated by a translational mechanism sensitive to media folate levels, while stable overexpression of its mRNA is mediated by gene amplification and an increase in transcript half-life. | 2001 Mar 26 | 1 |