Orotic Acid

dihydroorotate dehydrogenase (quinone) ; Homo sapiens







22 Article(s)
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Title
Pub. Year
#Total Relationships
1 33571819 Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review. 2021 Apr 1
2 33610916 Inhibition of mitochondrial complex III induces differentiation in acute myeloid leukemia. 2021 Apr 2 1
3 33716051 Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication. 2021 May 1
4 33981038 DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. 2021 May 2
5 34111397 Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors "leflunomide" and "teriflunomide" in Covid-19: A narrative review. 2021 Sep 5 1
6 34442810 The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses. 2021 Aug 14 2
7 34730931 Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth. 2021 Nov 19 2
8 29632820 Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase from Trypanosoma brucei. 2018 Apr 1
9 29939742 Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors. 2018 Jul 26 1
10 30459406 Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis. 2018 Nov 21 1
11 28118956 Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase. 2017 Feb 15 2
12 27906623 Orotate (orotic acid): An essential and versatile molecule. 2016 Dec 2
13 26059769 Orotic Acid, More Than Just an Intermediate of Pyrimidine de novo Synthesis. 2015 May 20 1
14 22242798 CoMFA and CoMSIA studies on aryl carboxylic acid amide derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors. 2012 Dec 1 1
15 21436031 Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis. 2011 Apr 5 1
16 17369345 Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo. 2007 May 1
17 12189151 Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. 2002 Nov 1 1
18 16120318 Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells. 2002 Dec 1
19 11329288 Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase. 2001 Feb 20 2
20 10889450 Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide. 2000 Apr 15 2
21 2306795 Phase I study of Brequinar sodium (NSC 368390) in patients with solid malignancies. 1990 1
22 2847745 Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. 1988 Oct 15 1