| 1 |
31857119 | Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies. | 2020 Jun |
1 |
| 2 |
32419814 | CBS-Induced H2S Generation in Hippocampus Inhibits EA-Induced Analgesia. | 2020 |
1 |
| 3 |
33000151 | Metabolism of Sulfur-Containing Amino Acids: How the Body Copes with Excess Methionine, Cysteine, and Sulfide. | 2020 Oct 1 |
4 |
| 4 |
31450076 | A diet rich in taurine, cysteine, folate, B12 and betaine may lessen risk for Alzheimer's disease by boosting brain synthesis of hydrogen sulfide. | 2019 Nov |
2 |
| 5 |
29119254 | Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria. | 2018 |
4 |
| 6 |
29275181 | Crystal structure of cystathionine β-synthase from honeybee Apis mellifera. | 2018 Apr |
1 |
| 7 |
28421128 | A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? | 2017 |
2 |
| 8 |
28656194 | Excessive nNOS/NO/AMPK signaling activation mediated by the blockage of the CBS/H2S system contributes to oxygen‑glucose deprivation‑induced endoplasmic reticulum stress in PC12 cells. | 2017 Aug |
2 |
| 9 |
29037129 | Enzymes Regulated via Cystathionine β-Synthase Domains. | 2017 Oct |
1 |
| 10 |
26582199 | S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase. | 2016 Jan 8 |
1 |
| 11 |
26765812 | Vitamin B6 nutritional status and cellular availability of pyridoxal 5'-phosphate govern the function of the transsulfuration pathway's canonical reactions and hydrogen sulfide production via side reactions. | 2016 Jul |
1 |
| 12 |
26805382 | Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria. | 2016 Jul |
3 |
| 13 |
26931358 | Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions. | 2016 |
1 |
| 14 |
27365395 | Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress. | 2016 Aug 5 |
1 |
| 15 |
26307088 | DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer. | 2015 Nov 1 |
1 |
| 16 |
23974653 | Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients. | 2014 Mar |
5 |
| 17 |
24667534 | Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro. | 2014 Sep 15 |
6 |
| 18 |
24780582 | The role of surface electrostatics on the stability, function and regulation of human cystathionine β-synthase, a complex multidomain and oligomeric protein. | 2014 Sep |
2 |
| 19 |
25044645 | Insights into the regulatory domain of cystathionine Beta-synthase: characterization of six variant proteins. | 2014 Oct |
2 |
| 20 |
25197074 | Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine. | 2014 Sep 16 |
1 |
| 21 |
25336647 | Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation. | 2014 Dec 26 |
1 |
| 22 |
22985361 | Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM. | 2013 Jan 1 |
5 |
| 23 |
23002992 | Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases. | 2013 Jan 29 |
2 |
| 24 |
24043838 | Structural basis of regulation and oligomerization of human cystathionine β-synthase, the central enzyme of transsulfuration. | 2013 Oct 1 |
2 |
| 25 |
22612060 | Conformational properties of nine purified cystathionine β-synthase mutants. | 2012 Jun 12 |
2 |
| 26 |
23143240 | Purification, crystallization and preliminary crystallographic analysis of human cystathionine β-synthase. | 2012 Nov 1 |
2 |
| 27 |
20821054 | Determination of cystathionine beta-synthase activity in human plasma by LC-MS/MS: potential use in diagnosis of CBS deficiency. | 2011 Feb |
3 |
| 28 |
21275900 | Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-β- synthase (CBS) and cystathionine-γ-lyase (CSE). | 2011 Apr |
1 |
| 29 |
20026078 | Binding of S-methyl-5'-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair. | 2010 Feb 26 |
3 |
| 30 |
19531479 | Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions. | 2009 Aug 14 |
3 |
| 31 |
17629356 | Hydrogen sulfide: neurochemistry and neurobiology. | 2008 Jan |
1 |
| 32 |
18060852 | Purification and characterization of the wild type and truncated human cystathionine beta-synthase enzymes expressed in E. coli. | 2008 Feb 1 |
1 |
| 33 |
18849566 | Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone. | 2008 Dec 12 |
1 |
| 34 |
16614071 | S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. | 2006 Apr 25 |
5 |
| 35 |
16953589 | Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding. | 2006 Sep 12 |
5 |
| 36 |
16047261 | Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. | 2005 May |
1 |
| 37 |
16275737 | CBS domains: structure, function, and pathology in human proteins. | 2005 Dec |
2 |
| 38 |
15642325 | The presence of a transsulfuration pathway in the lens: a new oxidative stress defense system. | 2004 Dec |
1 |
| 39 |
12801808 | [Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease?. 1. Basic data]. | 2003 Mar |
1 |
| 40 |
12007221 | High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations. | 2002 Jun |
2 |
| 41 |
12054683 | Brain hydrogen sulfide is severely decreased in Alzheimer's disease. | 2002 May 24 |
2 |
| 42 |
12115739 | Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae. | 2002 Jul |
2 |
| 43 |
11042162 | Functional properties of the active core of human cystathionine beta-synthase crystals. | 2001 Jan 5 |
1 |
| 44 |
11524006 | Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region. | 2001 Sep 4 |
3 |
| 45 |
11103808 | Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-D-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: a model of leukemia in Down syndrome. | 2000 Nov 15 |
2 |
| 46 |
10448523 | Homocysteine metabolism. | 1999 |
1 |
| 47 |
8558235 | The possible role of hydrogen sulfide as an endogenous neuromodulator. | 1996 Feb 1 |
5 |
| 48 |
8755636 | Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient. | 1996 Jul 15 |
4 |
| 49 |
7967489 | Komrower Lecture. Molecular basis of phenotype expression in homocystinuria. | 1994 |
1 |