Azathioprine

thiopurine S-methyltransferase ; Homo sapiens







283 Article(s)
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1 32842934 A rare case of Azathioprine-induced leukopenia in an European woman. 2022 Feb 1
2 34582038 TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results. 2022 Jan 7
3 34751173 A novel NUDT15 variant identified in Caucasian TPMT wild type patients with inflammatory bowel disease and azathioprine-related myelotoxicity. 2022 Jan 1 1
4 34870401 The Examination of a TPMT Gene Before Administration of Azathioprine in Rheumatology Practice and Identification of a Novel Variant p.W29R. 2022 Mar 1 4
5 35118815 Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity. 2022 Apr 4
6 35192152 Genotype-Guided Prescription of Azathioprine Reduces the Incidence of Adverse Drug Reactions in TPMT Intermediate Metabolizers to a Similar Incidence as Normal Metabolizers. 2022 Apr 3
7 35450035 Gut Microbiota Metabolism of Azathioprine: A New Hallmark for Personalized Drug-Targeted Therapy of Chronic Inflammatory Bowel Disease. 2022 2
8 32617765 Precision medicine for rheumatologists: lessons from the pharmacogenomics of azathioprine. 2021 Jan 2
9 33406412 TPMT and HLA-DQA1-HLA-DRB genetic profiling to guide the use of azathioprine in the treatment of interstitial lung disease: First experience. 2021 Feb 2
10 33846471 Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis. 2021 Apr 12 1
11 33929082 Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients. 2021 May 3
12 34027115 Predictors of azathioprine toxicity in children with autoimmune hepatitis. 2021 Mar 5
13 34141785 Bone marrow inhibition induced by azathioprine in a patient without mutation in the thiopurine S-methyltransferase pathogenic site: A case report. 2021 Jun 16 2
14 34430579 Cost-effectiveness analysis of genotype screening and therapeutic drug monitoring in patients with inflammatory bowel disease treated with azathioprine therapy: a Chinese healthcare perspective using real-world data. 2021 Jul 4
15 32054992 Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice. 2020 Oct 3
16 32062783 Predictive Value of NUDT15 Variants on Neutropenia Among Han Chinese Patients with Dermatologic Diseases: A Single-Center Observational Study. 2020 Apr 2
17 32070863 Myasthenia gravis and azathioprine treatment: Adverse events related to thiopurine S-methyl-transferase (TPMT) polymorphisms. 2020 May 15 6
18 32187056 Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease. 2020 Apr 20 1
19 32704308 Thiopurine S-methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population. 2020 6
20 32713039 Complete remission of refractory pemphigus vulgaris in a Chinese patient with mutated NUDT15 by combination of minimal doses of azathioprine and prednisone. 2020 Nov 2
21 33081236 Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT. 2020 Oct 16 4
22 33229787 Thiopurine S-methyltransferase Genetic Polymorphism and Its Contribution for Azathioprine-Induced Myelosuppression in Kidney Transplant Recipients: A Summative Analysis. 2020 Sep-Oct 1
23 30368003 Azathioprine Hypersensitivity Syndrome in a Cohort of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients. 2019 Mar 1
24 30451123 Thiopurine Methyltransferase Genetic Polymorphisms and Activity and Metabolic Products of Azathioprine in Patients with Inflammatory Bowel Disease. 2019 5
25 30686035 [Frequency of serious adverse events of thiopurine treatment in normal thiopurine S-methyltransferase genotype children with inflammatory bowel disease]. 2019 Feb 1
26 30840585 Combined evaluation of genotype and phenotype of thiopurine S-methyltransferase (TPMT) in the clinical management of patients in chronic therapy with azathioprine. 2019 Mar 6 6
27 30963516 Modeling the Outcome of Systematic TPMT Genotyping or Phenotyping Before Azathioprine Prescription: A Cost-Effectiveness Analysis. 2019 Jun 3
28 30987408 Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants. 2019 Apr 4 1
29 31024313 NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis. 2019 4
30 31387318 Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients. 2019 Aug 5 2
31 31427963 Application of Economic Evaluation to Assess Feasibility for Reimbursement of Genomic Testing as Part of Personalized Medicine Interventions. 2019 1
32 31464791 Severe pancytopenia and aspergillosis caused by thioguanine in a thiopurine S-methyltransferase deficient patient: a case report. 2019 Dec 3
33 31556692 NUDT15 and TPMT Genetic Polymorphisms Are Related to Azathioprine Intolerance in Chinese Patients with Rheumatic Diseases. 2019 Oct 1
34 31631819 TPMT Genotype and Adverse Effects of Azathioprine among Jordanian Group. 2019 2
35 29270995 HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease. 2018 Mar 1
36 29370945 [Usefulness of thiopurine methyltransferase polymorphism study and metabolites measurement for patients treated by azathioprine]. 2018 Jun 3
37 29421584 Effective long-term solution to therapeutic remission in Inflammatory Bowel Disease: Role of Azathioprine. 2018 Apr 4
38 29491687 Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease. 2018 Feb 28 3
39 29630648 Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study. 2018 2
40 29702976 NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review. 2018 Apr 2
41 29720911 Association Between Thiopurine S-Methyltransferase (TPMT) Genetic Variants and Infection in Pediatric Heart Transplant Recipients Treated With Azathioprine: A Multi-Institutional Analysis. 2018 Mar-Apr 5
42 29867468 NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients. 2018 2
43 30106365 Neutropenia related to an azathioprine metabolic disorder induced by an inosine triphosphate pyrophosphohydrolase (ITPA) gene mutation in a patient with PR3-ANCA-positive microscopic polyangiitis
. 2018 Nov 2
44 30477053 Thiopurine S-methyltransferase (TPMT) Mutation Prevalence and Myelosuppression Frequency in North Indian Patients with Autoimmune Disorders. 2018 May 2
45 28081040 Azathioprine Therapy in a Pediatric TPMT-Deficient Patient-Still an Option. 2017 Feb 4
46 28650902 ITPA Activity in Adults and Children Treated With or Without Azathioprine: Relationship Between TPMT Activity, Thiopurine Metabolites, and Co-medications. 2017 Oct 5
47 28813730 Point-Counterpoint: TPMT Genotyping for Azathioprine in Adult Medicine. 2017 Apr 1
48 28857898 Prevalence of thiopurine S-methyltransferase gene polymorphisms in patients with inflammatory bowel disease from the island of Crete, Greece. 2017 Nov 2
49 28966507 Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients. 2017 Oct 9
50 29441893 Effect of genetic polymorphisms of azathioprine-metabolizing enzymes on response to rheumatoid arthritis treatment. 2017 Jan 10 2