Phenobarbital

cytochrome P450, family 2, subfamily b, polypeptide 2 ; Rattus norvegicus







66 Article(s)
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1 21763762 N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital. 2011 Oct 10 1
2 21988088 Evidence for cytochrome P450 2B1/2B2 isoenzymes in freshly prepared peripheral blood lymphocytes. 2011 Dec 2
3 19737542 Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver. 2010 Feb 1 2
4 18164277 Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes. 2008 Mar 1 7
5 18486294 Inhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats. 2008 Jul 2
6 18528841 Establishment of a PF2D-MS/MS platform for rapid profiling and semiquantitative analysis of membrane protein biomarkers. 2008 Jun 1
7 18670162 Blood coagulation-related parameter changes in Sprague-Dawley (SD) rats treated with phenobarbital (PB) and PB plus vitamin K. 2008 Aug 3
8 15656786 The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX-PREP1, the thyroid hormone receptor beta and the liver X receptor. 2005 Jun 1 3
9 16421897 Quantification of the expression and inducibility of 12 rat cytochrome P450 isoforms by quantitative RT-PCR. 2005 1
10 15345328 GABA(A)/central benzodiazepine receptor and peripheral benzodiazepine receptor ligands as inducers of phenobarbital-inducible CYP2B and CYP3A. 2004 Oct 1 2
11 12920159 Spurious observation of splenic cyp2b1 expression. 2003 Sep 1
12 12028663 Metabolite of 2,2',4',5-tetrabromobiphenyl, 3-methylsulphonyl-2,2',4',5-tetrabromobiphenyl, a potent inducer of CYP2B1/2 in rat. 2002 Apr 2
13 11377393 Functional analysis of the phenobarbital-responsive unit in rat CYP2B2. 2001 Jul 1 3
14 11518807 Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. 2001 Sep 2
15 10788445 A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. 2000 May 5 2
16 10945841 Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers. 2000 Sep 3
17 11082433 Sequence analyses of CYP2B genes and catalytic profiles for P450s in Qdj:Sprague-dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2. 2000 Dec 3
18 9890442 Insulin-mediated modulation of cytochrome P450 gene induction profiles in primary rat hepatocyte cultures. 1999 1
19 10036216 Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers. 1999 Feb 15 2
20 10072770 Phenobarbital responsiveness conferred by the 5'-flanking region of the rat CYP2B2 gene in transgenic mice. 1999 Mar 4 1
21 10423399 Cis-acting sequences from the rat cytochrome P450 2B1 gene confer pulmonary and phenobarbital-inducible expression in transgenic mice. 1999 Aug 1
22 10529397 Phosphorylation/Dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital. 1999 Oct 22 5
23 10796078 Positive regulation of the rat CYP2B2 phenobarbital response unit by the nuclear receptor hexamer half-site.nuclear factor 1 complex. 1999 May 1 3
24 9525968 The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. 1998 Apr 3 6
25 9628589 Nuclear factor-1 motif and redundant regulatory elements comprise phenobarbital-responsive enhancer in CYP2B1/2. 1998 May 3
26 9630454 Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner. 1998 May 2
27 9664231 Differential induction of cytochrome P450 gene expression by 4n-alkyl-methylenedioxybenzenes in primary rat hepatocyte cultures. 1998 1
28 9678251 Identification of sequences involved in both basal expression and phenobarbital induction of a CYP2B2 gene using in vitro transcription system. 1998 Jun 2
29 8990265 A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in dwarf rats: reversal of the profiles by growth hormone-treatment. 1997 Jan 1 1
30 9063451 Regulation of the major detoxication functions by phenobarbital and 3-methylcholanthrene in co-cultures of rat hepatocytes and liver epithelial cells. 1997 Feb 15 3
31 9101035 Chlorodibromomethane metabolism to bromide and carbon monoxide in rats. 1997 2
32 9262383 An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures. 1997 Aug 1
33 9280408 Effect of ovariectomy and androgen on phenobarbital induction of hepatic CYP2B1 and CYP2B2 in Sprague-Dawley rats. 1997 Aug 2
34 8573202 Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins. 1996 Feb 9 2
35 8643092 Phenobarbital induction of hepatic CYP2B1 and CYP2B2: pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose. 1996 Mar 5
36 8769571 The CYP2B1 proximal promoter contains a functional C/EBP regulatory element. 1996 Aug 1
37 8798596 Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ. 1996 Sep 27 2
38 8912644 In vivo phenobarbital treatment increases protein binding to a putative AP-1 site in the CYP2B2 promoter. 1996 Nov 1 2
39 8937440 New proteins in the rat CYP2B subfamily: presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA. 1996 Oct 25 1
40 8954103 Insulin suppresses the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes. 1996 Dec 4 10
41 7607552 Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene. 1995 Jun 9 4
42 7646073 Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: genetic differences in a common regulatory mechanism. 1995 Aug 20 3
43 7759530 cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures. 1995 May 26 1
44 7773300 Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. 1995 Feb 4
45 8577819 Depletion of cytochrome P-450 by thyroid hormone and cobalt-protoporphyrin IX in rat liver: evidence that susceptibility varies among forms of the heme protein. 1995 Oct 1
46 8615872 Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats. 1995 Nov 27 1
47 7979401 The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific. 1994 Nov 15 2
48 8018775 [Induction of cytochromes P-4501A and 2B in various rat organs, subjected to hexachlorobenzene and aroclor 1254]. 1994 Apr 1
49 8068204 Interaction of proteins with a cytochrome P450 2B2 gene promoter: identification of two DNA sequences that bind proteins that are enriched or activated in response to phenobarbital. 1994 Aug 2
50 8138968 Cytochrome P450 2B enzyme induction defect after 2,2',4,4',5,5'-hexachlorobiphenyl treatment in the fa/fa Zucker rat. 1994 Mar 1