Benzo(a)pyrene

cytochrome P450, family 1, subfamily a, polypeptide 1 ; Rattus norvegicus







89 Article(s)
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1 34199736 Daytime Restricted Feeding Modifies the Temporal Expression of CYP1A1 and Attenuated Damage Induced by Benzo[a]pyrene in Rat Liver When Administered before CYP1A1 Acrophase. 2021 Jun 4 5
2 34360828 Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes. 2021 Jul 28 1
3 33213213 Effects of prolonged subchronic benzo(α)pyrene exposure on rat liver morphology and CYP1A expression during treatment with menadione, quercetin, or tocopherol. 2020 Nov 19 1
4 31698770 Curcumin Ameliorates Benzo[a]pyrene-Induced DNA Damages in Stomach Tissues of Sprague-Dawley Rats. 2019 Nov 6 2
5 29649501 Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats. 2018 May 1 1
6 27099206 Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices. 2017 Mar 2
7 27110038 NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1. 2016 2
8 27167070 Menadione Suppresses Benzo(α)pyrene-Induced Activation of Cytochromes P450 1A: Insights into a Possible Molecular Mechanism. 2016 2
9 28263535 Exposure of rats to exogenous endocrine disruptors 17alpha-ethinylestradiol and benzo(a)pyrene and an estrogenic hormone estradiol induces expression of cytochromes P450 involved in their metabolism. 2016 Dec 18 3
10 23406957 Silymarin prevents benzo(a)pyrene-induced toxicity in Wistar rats by modulating xenobiotic-metabolizing enzymes. 2015 Jun 1
11 25854346 Inhibitory effect of phenethyl isothiocyanate against benzo[a] pyrene-induced rise in CYP1A1 mRNA and apoprotein levels as its chemopreventive properties. 2015 2
12 26466350 Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver. 2015 2
13 25638381 Effect of dihydromyricetin on benzo[a]pyrene activation in rats. 2014 3
14 23956140 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. 2013 Nov 1
15 24362093 Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study. 2013 1
16 22174033 Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor. 2012 Mar 1
17 22643862 The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. 2012 Oct 1
18 22785257 Differential inducing effect of benzo[a]pyrene on gene expression and enzyme activity of cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar rats. 2012 1
19 22856136 [Tissue-specific expression of hormonal carcinogenesis target genes in rats treated with polycyclic aromatic hydrocarbons]. 2012 May-Jun 1
20 22960446 Neonatal exposure to benzo[a]pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats. 2012 Dec 16 1
21 23059060 Endocrine disruptive actions of inhaled benzo(a)pyrene on ovarian function and fetal survival in fisher F-344 adult rats. 2012 Dec 1
22 20947330 An amperometric biosensor based on rat cytochrome p450 1A1 for benzo[a]pyrene determination. 2011 Jan 15 3
23 21383588 Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene. 2011 Mar 1
24 21942922 Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants. 2011 Nov 21 4
25 22167217 Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens. 2011 2
26 21217860 Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method. 2009 Dec 1
27 18336843 Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression. 2008 Apr 2 2
28 17991490 The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes. 2007 Nov 30 4
29 16198082 Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. 2006 Jun 9
30 16237193 Preferential induction of CYP1A1 and CYP1B1 in CCSP-positive cells. 2006 Jan 1
31 16541199 Involvement of endogenous nitric oxide in myeloperoxidase mediated benzo(a)pyrene induced polymorphonuclear leukocytes injury. 2006 Jun 2
32 14656999 Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons. 2004 Feb 1
33 15061698 Cytochrome P-450 family 1 in rat embryo cell culture immortalized by Rausher leukemia virus. 2004 Mar 1
34 15211619 Influence of iron (56Fe2O3 or 54Fe2O3) in the upregulation of cytochrome P4501A1 by benzo[a]pyrene in the respiratory tract of Sprague-Dawley rats. 2004 May-Jun 7
35 12893519 Use of cultured precision-cut rat lung slices to study the in vitro induction of pulmonary cytochrome P450 forms. 2003 Jul 1
36 12927582 Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene. 2003 Oct 1
37 11346483 Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. 2001 Jun 1
38 11682644 S9 induction by the combined treatment with cyclohexanol and albendazole. 2001 Nov 1
39 10711631 Aryl hydrocarbon hydroxylase activity in F-344 rats subchronically exposed to benzo(a)pyrene and fluoranthene through diet. 2000 5
40 9858665 Cytochrome P450 1A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo[a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro. 1999 Jan 2 2
41 10190573 Potency of various polycyclic aromatic hydrocarbons as inducers of CYP1A1 in rat hepatocyte cultures. 1999 Jan 29 2
42 10224324 Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies. 1999 Apr 26 1
43 10381141 Inhibition by retinoids of benzo(A)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1. 1999 Jun 3
44 23898793 Short Communication: The effect of CYP1A1 induction on the formation of benzo a pyrene adducts in liver and lung DNA and plasma albumin in rats exposed to benzo a pyrene:adduct quantitation by immunoassay and an HPLC method. 1999 2
45 9341155 Transport of rat liver glycine N-methyltransferase into rat liver nuclei. 1997 Oct 24 1
46 8598570 Low-level m-Xylene inhalation alters pulmonary and hepatic cytochrome P-450 activity in the rat. 1996 Feb 9 1
47 21544413 Effect of inducer and inhibitor probes on DNA adduction of benzo[a]pyrene and 2-acetylaminofluorene and their roles in defining bioactivation mechanism(s). 1996 Apr 1
48 7574713 Glycine N-methyltransferase is a mediator of cytochrome P4501A1 gene expression. 1995 Oct 1 1
49 7581497 Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells. 1995 2
50 7587963 Induction of liver microsomal cytochrome P450 in cynomolgus monkeys. 1995 Jul 2