| 101 |
14690438 | Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain. | 2003 Dec 30 |
1 |
| 102 |
14705776 | Purification, analysis, and preservation of reduced nicotinamide adenine dinucleotide 2'-phosphate. | 2003 Nov 1 |
1 |
| 103 |
11284680 | Interligand Overhauser effects in type II dihydrofolate reductase. | 2001 Apr 10 |
2 |
| 104 |
11509884 | Murine cytomegalovirus infection induces cellular folylpolyglutamate synthetase activity in quiescent cells. | 2001 |
2 |
| 105 |
11774738 | Antifolate resistance and its circumvention by new analogues. | 2001 Sep |
2 |
| 106 |
11962509 | Investigations on the biological properties of the lipophilic DHFR-inhibitory benzoprims reveal non-folate modes of action and opportunities for anti-cancer drug design. | 2001 Apr-Jun |
1 |
| 107 |
11989624 | One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme. | 2001 Nov |
1 |
| 108 |
11996001 | Computer modeling studies of the structural role of NADPH binding to active site mutants of human dihydrofolate reductase in complex with piritrexim. | 2001 |
1 |
| 109 |
10683342 | Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. | 2000 Mar 1 |
2 |
| 110 |
10739874 | The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine. | 2000 Mar |
1 |
| 111 |
10993224 | Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(omega)-masked ornithine analogs. | 2000 Sep |
1 |
| 112 |
9952321 | Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines. | 1999 Mar 1 |
4 |
| 113 |
10584062 | Enzyme polarization of substrates of dihydrofolate reductase by different theoretical methods. | 1999 Nov 1 |
1 |
| 114 |
9679969 | Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation. | 1998 Jul 15 |
2 |
| 115 |
9723869 | The mosquito dihydrofolate reductase amplicon contains a truncated synaptic vesicle protein gene. | 1998 Nov |
1 |
| 116 |
9762364 | Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention? | 1998 |
1 |
| 117 |
9857014 | The sec-independent twin-arginine translocation system can transport both tightly folded and malfolded proteins across the thylakoid membrane. | 1998 Dec 25 |
1 |
| 118 |
10499129 | Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry. | 1998 Apr |
1 |
| 119 |
9012448 | Retrovirally mediated gene transfer of Arg22 and Tyr22 forms of dihydrofolate reductase into the hematopoietic cell line K562: a comparison of methotrexate resistance. | 1997 Jan-Feb |
1 |
| 120 |
9479873 | Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance. | 1997 Dec |
1 |
| 121 |
8913793 | In vitro and in vivo biological activities of a novel nonpolyglutamable anti-folate, MX-68. | 1996 Oct |
1 |
| 122 |
8978793 | [Methotrexate in gynecologic oncology]. | 1996 Dec |
2 |
| 123 |
7783147 | Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases. | 1995 Jun 9 |
1 |
| 124 |
8527095 | Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding. | 1995 Sep |
1 |
| 125 |
8852336 | Molecular mechanisms of resistance to antifolates, a review. | 1995 |
1 |
| 126 |
7942284 | The methotrexate story: a paradigm for development of cancer chemotherapeutic agents. | 1994 |
1 |
| 127 |
8164259 | Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. | 1994 Apr 15 |
1 |
| 128 |
8195828 | Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors. | 1993 Dec |
2 |
| 129 |
8361048 | [Detection of alterations of dihydrofolate reductase gene in folate-resistant leukemia cells by in vitro enzymatic amplification]. | 1993 Jul |
1 |
| 130 |
8449831 | Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues. | 1993 Jan |
3 |
| 131 |
1314649 | Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency. | 1992 Apr 14 |
2 |
| 132 |
1529671 | Immunohistochemistry of dihydrofolate reductase in methotrexate-sensitive and -resistant human cell lines by flow cytometry: a comparison with the cytochemical tetrazolium salt method. | 1992 |
1 |
| 133 |
1637816 | Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates. | 1992 Jul 28 |
1 |
| 134 |
1768284 | Uptake, cytotoxicity and metabolism of m-azidopyrimethamine and related lipophilic antifolates in SV-K14 human keratinocytes in vivo. | 1991 Dec 11 |
1 |
| 135 |
1904273 | Synthesis and biological evaluation of a fluorescent analogue of folic acid. | 1991 Jun 11 |
5 |
| 136 |
1907850 | Conversion of arginine to lysine at position 70 of human dihydrofolate reductase: generation of a methotrexate-insensitive mutant enzyme. | 1991 Aug 20 |
2 |
| 137 |
2006139 | Electron redistribution on binding of a substrate to an enzyme: folate and dihydrofolate reductase. | 1991 |
1 |
| 138 |
2178951 | Thymidylate synthase-dihydrofolate reductase in protozoa. | 1990 Apr |
2 |
| 139 |
2180768 | Bifunctional thymidylate synthase-dihydrofolate reductase in protozoa. | 1990 Apr 1 |
2 |
| 140 |
2248959 | Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. | 1990 Oct 9 |
1 |
| 141 |
2260989 | Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells. | 1990 Dec 15 |
1 |
| 142 |
3339615 | Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin. | 1988 Feb |
1 |
| 143 |
2448654 | Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. | 1987 |
1 |
| 144 |
6193143 | Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase. | 1983 Sep |
2 |
| 145 |
6661412 | Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate. | 1983 Dec 6 |
1 |
| 146 |
6882460 | A mechanism of resistance to methotrexate. NADPH but not NADH stimulation of methotrexate binding to dihydrofolate reductase. | 1983 Jun 15 |
1 |
| 147 |
7140422 | Evaluation of X-methyl folate preparations as possible folic acid antagonists. | 1982 |
2 |
| 148 |
7423195 | Folic acid: crystal structure and implications for enzyme binding. | 1980 Oct 17 |
1 |
| 149 |
109617 | Synthesis of aza homologues of folic acid. | 1979 Jul |
1 |
| 150 |
814898 | Interaction of 13C-enriched folate with dihydrofolate reductase studies by carbon magnetic resonance spectroscopy. | 1976 Jan 26 |
1 |