150 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
101 | 14690438 | Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain. | 2003 Dec 30 | 1 |
102 | 14705776 | Purification, analysis, and preservation of reduced nicotinamide adenine dinucleotide 2'-phosphate. | 2003 Nov 1 | 1 |
103 | 11284680 | Interligand Overhauser effects in type II dihydrofolate reductase. | 2001 Apr 10 | 2 |
104 | 11509884 | Murine cytomegalovirus infection induces cellular folylpolyglutamate synthetase activity in quiescent cells. | 2001 | 2 |
105 | 11774738 | Antifolate resistance and its circumvention by new analogues. | 2001 Sep | 2 |
106 | 11962509 | Investigations on the biological properties of the lipophilic DHFR-inhibitory benzoprims reveal non-folate modes of action and opportunities for anti-cancer drug design. | 2001 Apr-Jun | 1 |
107 | 11989624 | One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme. | 2001 Nov | 1 |
108 | 11996001 | Computer modeling studies of the structural role of NADPH binding to active site mutants of human dihydrofolate reductase in complex with piritrexim. | 2001 | 1 |
109 | 10683342 | Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. | 2000 Mar 1 | 2 |
110 | 10739874 | The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine. | 2000 Mar | 1 |
111 | 10993224 | Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(omega)-masked ornithine analogs. | 2000 Sep | 1 |
112 | 9952321 | Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines. | 1999 Mar 1 | 4 |
113 | 10584062 | Enzyme polarization of substrates of dihydrofolate reductase by different theoretical methods. | 1999 Nov 1 | 1 |
114 | 9679969 | Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation. | 1998 Jul 15 | 2 |
115 | 9723869 | The mosquito dihydrofolate reductase amplicon contains a truncated synaptic vesicle protein gene. | 1998 Nov | 1 |
116 | 9762364 | Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention? | 1998 | 1 |
117 | 9857014 | The sec-independent twin-arginine translocation system can transport both tightly folded and malfolded proteins across the thylakoid membrane. | 1998 Dec 25 | 1 |
118 | 10499129 | Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry. | 1998 Apr | 1 |
119 | 9012448 | Retrovirally mediated gene transfer of Arg22 and Tyr22 forms of dihydrofolate reductase into the hematopoietic cell line K562: a comparison of methotrexate resistance. | 1997 Jan-Feb | 1 |
120 | 9479873 | Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance. | 1997 Dec | 1 |
121 | 8913793 | In vitro and in vivo biological activities of a novel nonpolyglutamable anti-folate, MX-68. | 1996 Oct | 1 |
122 | 8978793 | [Methotrexate in gynecologic oncology]. | 1996 Dec | 2 |
123 | 7783147 | Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases. | 1995 Jun 9 | 1 |
124 | 8527095 | Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding. | 1995 Sep | 1 |
125 | 8852336 | Molecular mechanisms of resistance to antifolates, a review. | 1995 | 1 |
126 | 7942284 | The methotrexate story: a paradigm for development of cancer chemotherapeutic agents. | 1994 | 1 |
127 | 8164259 | Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. | 1994 Apr 15 | 1 |
128 | 8195828 | Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors. | 1993 Dec | 2 |
129 | 8361048 | [Detection of alterations of dihydrofolate reductase gene in folate-resistant leukemia cells by in vitro enzymatic amplification]. | 1993 Jul | 1 |
130 | 8449831 | Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues. | 1993 Jan | 3 |
131 | 1314649 | Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency. | 1992 Apr 14 | 2 |
132 | 1529671 | Immunohistochemistry of dihydrofolate reductase in methotrexate-sensitive and -resistant human cell lines by flow cytometry: a comparison with the cytochemical tetrazolium salt method. | 1992 | 1 |
133 | 1637816 | Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates. | 1992 Jul 28 | 1 |
134 | 1768284 | Uptake, cytotoxicity and metabolism of m-azidopyrimethamine and related lipophilic antifolates in SV-K14 human keratinocytes in vivo. | 1991 Dec 11 | 1 |
135 | 1904273 | Synthesis and biological evaluation of a fluorescent analogue of folic acid. | 1991 Jun 11 | 5 |
136 | 1907850 | Conversion of arginine to lysine at position 70 of human dihydrofolate reductase: generation of a methotrexate-insensitive mutant enzyme. | 1991 Aug 20 | 2 |
137 | 2006139 | Electron redistribution on binding of a substrate to an enzyme: folate and dihydrofolate reductase. | 1991 | 1 |
138 | 2178951 | Thymidylate synthase-dihydrofolate reductase in protozoa. | 1990 Apr | 2 |
139 | 2180768 | Bifunctional thymidylate synthase-dihydrofolate reductase in protozoa. | 1990 Apr 1 | 2 |
140 | 2248959 | Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. | 1990 Oct 9 | 1 |
141 | 2260989 | Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells. | 1990 Dec 15 | 1 |
142 | 3339615 | Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin. | 1988 Feb | 1 |
143 | 2448654 | Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. | 1987 | 1 |
144 | 6193143 | Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase. | 1983 Sep | 2 |
145 | 6661412 | Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate. | 1983 Dec 6 | 1 |
146 | 6882460 | A mechanism of resistance to methotrexate. NADPH but not NADH stimulation of methotrexate binding to dihydrofolate reductase. | 1983 Jun 15 | 1 |
147 | 7140422 | Evaluation of X-methyl folate preparations as possible folic acid antagonists. | 1982 | 2 |
148 | 7423195 | Folic acid: crystal structure and implications for enzyme binding. | 1980 Oct 17 | 1 |
149 | 109617 | Synthesis of aza homologues of folic acid. | 1979 Jul | 1 |
150 | 814898 | Interaction of 13C-enriched folate with dihydrofolate reductase studies by carbon magnetic resonance spectroscopy. | 1976 Jan 26 | 1 |