Folic Acid

dihydrofolate reductase ; Homo sapiens







150 Article(s)
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101 14690438 Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain. 2003 Dec 30 1
102 14705776 Purification, analysis, and preservation of reduced nicotinamide adenine dinucleotide 2'-phosphate. 2003 Nov 1 1
103 11284680 Interligand Overhauser effects in type II dihydrofolate reductase. 2001 Apr 10 2
104 11509884 Murine cytomegalovirus infection induces cellular folylpolyglutamate synthetase activity in quiescent cells. 2001 2
105 11774738 Antifolate resistance and its circumvention by new analogues. 2001 Sep 2
106 11962509 Investigations on the biological properties of the lipophilic DHFR-inhibitory benzoprims reveal non-folate modes of action and opportunities for anti-cancer drug design. 2001 Apr-Jun 1
107 11989624 One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme. 2001 Nov 1
108 11996001 Computer modeling studies of the structural role of NADPH binding to active site mutants of human dihydrofolate reductase in complex with piritrexim. 2001 1
109 10683342 Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. 2000 Mar 1 2
110 10739874 The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine. 2000 Mar 1
111 10993224 Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(omega)-masked ornithine analogs. 2000 Sep 1
112 9952321 Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines. 1999 Mar 1 4
113 10584062 Enzyme polarization of substrates of dihydrofolate reductase by different theoretical methods. 1999 Nov 1 1
114 9679969 Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation. 1998 Jul 15 2
115 9723869 The mosquito dihydrofolate reductase amplicon contains a truncated synaptic vesicle protein gene. 1998 Nov 1
116 9762364 Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention? 1998 1
117 9857014 The sec-independent twin-arginine translocation system can transport both tightly folded and malfolded proteins across the thylakoid membrane. 1998 Dec 25 1
118 10499129 Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry. 1998 Apr 1
119 9012448 Retrovirally mediated gene transfer of Arg22 and Tyr22 forms of dihydrofolate reductase into the hematopoietic cell line K562: a comparison of methotrexate resistance. 1997 Jan-Feb 1
120 9479873 Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance. 1997 Dec 1
121 8913793 In vitro and in vivo biological activities of a novel nonpolyglutamable anti-folate, MX-68. 1996 Oct 1
122 8978793 [Methotrexate in gynecologic oncology]. 1996 Dec 2
123 7783147 Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases. 1995 Jun 9 1
124 8527095 Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding. 1995 Sep 1
125 8852336 Molecular mechanisms of resistance to antifolates, a review. 1995 1
126 7942284 The methotrexate story: a paradigm for development of cancer chemotherapeutic agents. 1994 1
127 8164259 Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. 1994 Apr 15 1
128 8195828 Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors. 1993 Dec 2
129 8361048 [Detection of alterations of dihydrofolate reductase gene in folate-resistant leukemia cells by in vitro enzymatic amplification]. 1993 Jul 1
130 8449831 Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues. 1993 Jan 3
131 1314649 Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency. 1992 Apr 14 2
132 1529671 Immunohistochemistry of dihydrofolate reductase in methotrexate-sensitive and -resistant human cell lines by flow cytometry: a comparison with the cytochemical tetrazolium salt method. 1992 1
133 1637816 Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates. 1992 Jul 28 1
134 1768284 Uptake, cytotoxicity and metabolism of m-azidopyrimethamine and related lipophilic antifolates in SV-K14 human keratinocytes in vivo. 1991 Dec 11 1
135 1904273 Synthesis and biological evaluation of a fluorescent analogue of folic acid. 1991 Jun 11 5
136 1907850 Conversion of arginine to lysine at position 70 of human dihydrofolate reductase: generation of a methotrexate-insensitive mutant enzyme. 1991 Aug 20 2
137 2006139 Electron redistribution on binding of a substrate to an enzyme: folate and dihydrofolate reductase. 1991 1
138 2178951 Thymidylate synthase-dihydrofolate reductase in protozoa. 1990 Apr 2
139 2180768 Bifunctional thymidylate synthase-dihydrofolate reductase in protozoa. 1990 Apr 1 2
140 2248959 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. 1990 Oct 9 1
141 2260989 Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells. 1990 Dec 15 1
142 3339615 Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin. 1988 Feb 1
143 2448654 Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. 1987 1
144 6193143 Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase. 1983 Sep 2
145 6661412 Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate. 1983 Dec 6 1
146 6882460 A mechanism of resistance to methotrexate. NADPH but not NADH stimulation of methotrexate binding to dihydrofolate reductase. 1983 Jun 15 1
147 7140422 Evaluation of X-methyl folate preparations as possible folic acid antagonists. 1982 2
148 7423195 Folic acid: crystal structure and implications for enzyme binding. 1980 Oct 17 1
149 109617 Synthesis of aza homologues of folic acid. 1979 Jul 1
150 814898 Interaction of 13C-enriched folate with dihydrofolate reductase studies by carbon magnetic resonance spectroscopy. 1976 Jan 26 1