Folic Acid

dihydrofolate reductase ; Homo sapiens







150 Article(s)
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51 23799623 Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells. 2013 Sep 1
52 23973753 Photogenotoxicity of folic acid. 2013 Dec 4
53 24053355 First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling. 2013 Oct 15 3
54 21956523 Pralatrexate: a novel synthetic antifolate for relapsed or refractory peripheral T-cell lymphoma and other potential uses. 2012 Jun 2
55 22530664 Rational administration schedule for high-dose methotrexate in patients with primary central nervous system lymphoma. 2012 Oct 1
56 22571483 Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children. 2012 Jul 1
57 22648968 Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. 2012 Dec 1 5
58 22943049 Monitoring methotrexate in clinical samples from cancer patients during chemotherapy with a LSPR-based competitive sensor. 2012 Oct 21 1
59 21126022 Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. 2011 Jan 13 1
60 21179031 Single agent and combination studies of pralatrexate and molecular correlates of sensitivity. 2011 Jan 18 1
61 21310276 Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency. 2011 Feb 11 1
62 21310277 Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. 2011 Feb 11 1
63 21568878 Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation. 2011 Jul 2
64 21726415 Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity. 2011 Oct 1
65 21876184 The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional. 2011 Sep 13 1
66 22023442 Folate metabolic pathways in Leishmania. 2011 3
67 19816791 Development of a targeted siRNA delivery system using FOL-PEG-PEI conjugate. 2010 Jul 2
68 19839929 The role of pemetrexed in advanced non small-cell lung cancer: special focus on pharmacology and mechanism of action. 2010 Jan 2
69 20424322 Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. 2010 May 2
70 21120433 19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism. 2010 Jul 2
71 21301589 Cancer chemotherapy: targeting folic acid synthesis. 2010 Nov 19 1
72 21629435 Dihydrofolate reductase gene variations in susceptibility to disease and treatment outcomes. 2010 Dec 5
73 18851711 Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis. 2009 Feb 1 2
74 19010378 Interaction between cytotoxic effects of gamma-radiation and folate deficiency in relation to choline reserves. 2009 Jan 8 2
75 19146480 Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. 2009 Jan 16 1
76 19174154 Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs. 2009 Apr 1 1
77 19536847 DHFR 19-bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia: is the risk reduction due to intracellular folate unbalancing? 2009 Aug 1
78 19706381 The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. 2009 Sep 8 4
79 19719239 Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. 2009 Aug 13 1
80 20049736 Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. 2009 Sep 1
81 18247058 An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women. 2008 Apr 6
82 19022952 A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. 2008 Dec 10
83 19850982 Folate deficiency followed by ionizing radiation perturbs hepatic dihydrofolate reducatse activity. 2008 7
84 16969375 Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. 2007 Jan 1
85 17336564 Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida. 2007 May 3
86 17413111 A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users. 2007 Apr 1
87 17446168 Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway. 2007 Jun 15 1
88 17486595 The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population. 2007 Jun 1 2
89 17597297 Preliminary evidence for involvement of the folate gene polymorphism 19bp deletion-DHFR in occurrence of autism. 2007 Jul 5 2
90 16712799 Leucovorin-induced resistance against FDH growth suppressor effects occurs through DHFR up-regulation. 2006 Jul 14 1
91 16790925 High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site. 2006 Jul 1
92 17661690 Folate metabolism as a source of molecular targets for antimalarials. 2006 Jun 1
93 15755837 Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm delivery. 2005 Mar 3
94 14735580 New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? 2004 Feb 1 2
95 15182183 Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis. 2004 Jun 15 1
96 15504856 Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis. 2004 Nov 1
97 12482753 Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. 2003 Feb 28 2
98 12583828 Novel antifolate drugs. 2003 Mar 1
99 12851689 Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells. 2003 Aug 2
100 14502550 Synthesis and in vitro evaluation of potential anti-leishmanial targeted drugs of pyrimethamine. 2003 Oct 1