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23799623 | Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells. | 2013 Sep |
1 |
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23973753 | Photogenotoxicity of folic acid. | 2013 Dec |
4 |
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24053355 | First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling. | 2013 Oct 15 |
3 |
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21956523 | Pralatrexate: a novel synthetic antifolate for relapsed or refractory peripheral T-cell lymphoma and other potential uses. | 2012 Jun |
2 |
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22530664 | Rational administration schedule for high-dose methotrexate in patients with primary central nervous system lymphoma. | 2012 Oct |
1 |
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22571483 | Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children. | 2012 Jul |
1 |
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22648968 | Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. | 2012 Dec 1 |
5 |
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22943049 | Monitoring methotrexate in clinical samples from cancer patients during chemotherapy with a LSPR-based competitive sensor. | 2012 Oct 21 |
1 |
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21126022 | Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. | 2011 Jan 13 |
1 |
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21179031 | Single agent and combination studies of pralatrexate and molecular correlates of sensitivity. | 2011 Jan 18 |
1 |
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21310276 | Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency. | 2011 Feb 11 |
1 |
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21310277 | Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. | 2011 Feb 11 |
1 |
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21568878 | Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation. | 2011 Jul |
2 |
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21726415 | Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity. | 2011 Oct |
1 |
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21876184 | The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional. | 2011 Sep 13 |
1 |
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22023442 | Folate metabolic pathways in Leishmania. | 2011 |
3 |
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19816791 | Development of a targeted siRNA delivery system using FOL-PEG-PEI conjugate. | 2010 Jul |
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2 |
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20424322 | Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. | 2010 May |
2 |
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21120433 | 19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism. | 2010 Jul |
2 |
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21301589 | Cancer chemotherapy: targeting folic acid synthesis. | 2010 Nov 19 |
1 |
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21629435 | Dihydrofolate reductase gene variations in susceptibility to disease and treatment outcomes. | 2010 Dec |
5 |
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18851711 | Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis. | 2009 Feb 1 |
2 |
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19010378 | Interaction between cytotoxic effects of gamma-radiation and folate deficiency in relation to choline reserves. | 2009 Jan 8 |
2 |
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19146480 | Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. | 2009 Jan 16 |
1 |
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19174154 | Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs. | 2009 Apr 1 |
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1 |
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19706381 | The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. | 2009 Sep 8 |
4 |
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19719239 | Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. | 2009 Aug 13 |
1 |
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20049736 | Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. | 2009 Sep |
1 |
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18247058 | An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women. | 2008 Apr |
6 |
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19022952 | A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. | 2008 Dec |
10 |
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19850982 | Folate deficiency followed by ionizing radiation perturbs hepatic dihydrofolate reducatse activity. | 2008 |
7 |
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16969375 | Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. | 2007 Jan |
1 |
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17336564 | Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida. | 2007 May |
3 |
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17413111 | A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users. | 2007 Apr |
1 |
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17446168 | Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway. | 2007 Jun 15 |
1 |
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17486595 | The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population. | 2007 Jun 1 |
2 |
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17597297 | Preliminary evidence for involvement of the folate gene polymorphism 19bp deletion-DHFR in occurrence of autism. | 2007 Jul 5 |
2 |
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16712799 | Leucovorin-induced resistance against FDH growth suppressor effects occurs through DHFR up-regulation. | 2006 Jul 14 |
1 |
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16790925 | High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site. | 2006 Jul |
1 |
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17661690 | Folate metabolism as a source of molecular targets for antimalarials. | 2006 Jun |
1 |
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15755837 | Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm delivery. | 2005 Mar |
3 |
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14735580 | New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? | 2004 Feb 1 |
2 |
| 95 |
15182183 | Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis. | 2004 Jun 15 |
1 |
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15504856 | Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis. | 2004 Nov |
1 |
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12482753 | Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. | 2003 Feb 28 |
2 |
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12583828 | Novel antifolate drugs. | 2003 Mar |
1 |
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12851689 | Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells. | 2003 Aug |
2 |
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1 |